5BUI
ERK2 complexed with 2-pyridiyl tetrahydroazaindazole
Summary for 5BUI
| Entry DOI | 10.2210/pdb5bui/pdb |
| Related | 5BUE 5BUJ |
| Descriptor | Mitogen-activated protein kinase 1, NICKEL (II) ION, 3-(4-fluorophenyl)-5-(pyridin-2-yl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine, ... (4 entities in total) |
| Functional Keywords | erk2, mitogen-activated protein kinase 1, atp-inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cytoplasm, cytoskeleton, spindle : P28482 |
| Total number of polymer chains | 1 |
| Total formula weight | 41820.64 |
| Authors | Bellamacina, C.R.,Shu, W.,Bussiere, D.E.,Bagdanoff, J.T. (deposition date: 2015-06-03, release date: 2015-07-15, Last modification date: 2023-09-27) |
| Primary citation | Bagdanoff, J.T.,Jain, R.,Han, W.,Poon, D.,Lee, P.S.,Bellamacina, C.,Lindvall, M. Ligand efficient tetrahydro-pyrazolopyridines as inhibitors of ERK2 kinase. Bioorg.Med.Chem.Lett., 25:3626-3629, 2015 Cited by PubMed: 26144345DOI: 10.1016/j.bmcl.2015.06.063 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.12 Å) |
Structure validation
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