6W2I
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![BU of 6w2i by Molmil](/molmil-images/mine/6w2i) | Crystal Structure of Y188G Variant of the Internal UBA Domain of HHR23A | 分子名称: | GLYCEROL, UV excision repair protein RAD23 homolog A | 著者 | Bowler, B.E, Zeng, B, Becht, D.C, Rothfuss, M, Sprang, S.R, Mou, T.-C. | 登録日 | 2020-03-05 | 公開日 | 2021-03-10 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | High-Accuracy Prediction of Stabilizing Surface Mutations to the Three-Helix Bundle, UBA(1), with EmCAST. J.Am.Chem.Soc., 145, 2023
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5DVS
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![BU of 5dvs by Molmil](/molmil-images/mine/5dvs) | Crystal Structure of the ER-alpha Ligand-binding Domain in Complex with a 2-Methyl-substituted Triaryl-imine 4,4'-[(2-methylphenyl)carbonimidoyl]diphenol | 分子名称: | 4,4'-[(2-methylphenyl)carbonimidoyl]diphenol, Estrogen receptor, Nuclear receptor coactivator 2 | 著者 | Nwachukwu, J.C, Wright, N.J, Srinivasan, S, Zheng, Y, Wang, S, Min, J, Dong, C, Liao, Z, Cavett, V, Nowak, J, Houtman, R, Carlson, K.E, Josan, J.S, Elemento, O, Katzenellenbogen, J.A, Zhou, H.B, Nettles, K.W. | 登録日 | 2015-09-21 | 公開日 | 2016-05-04 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Predictive features of ligand-specific signaling through the estrogen receptor. Mol.Syst.Biol., 12, 2016
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8G4E
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8G4H
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![BU of 8g4h by Molmil](/molmil-images/mine/8g4h) | KRAS G13C complex with GDP imaged on a cryo-EM imaging scaffold | 分子名称: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Castells-Graells, R, Sawaya, M.R, Yeates, T.O. | 登録日 | 2023-02-09 | 公開日 | 2023-08-09 | 最終更新日 | 2023-09-27 | 実験手法 | ELECTRON MICROSCOPY (2.87 Å) | 主引用文献 | Cryo-EM structure determination of small therapeutic protein targets at 3 angstrom -resolution using a rigid imaging scaffold. Proc.Natl.Acad.Sci.USA, 120, 2023
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8CLY
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![BU of 8cly by Molmil](/molmil-images/mine/8cly) | Crystal structure of Rhizobium etli constitutive L-asparaginase ReAIV (tetragonal form R4tP) | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Putative L-asparaginase II protein, ... | 著者 | Loch, J.I, Worsztynowicz, P, Sliwiak, J, Imiolczyk, B, Grzechowiak, M, Gilski, M, Jaskolski, M. | 登録日 | 2023-02-17 | 公開日 | 2023-08-09 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.503 Å) | 主引用文献 | Rhizobium etli has two L-asparaginases with low sequence identity but similar structure and catalytic center. Acta Crystallogr D Struct Biol, 79, 2023
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8G42
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![BU of 8g42 by Molmil](/molmil-images/mine/8g42) | KRAS G12C complex with GDP imaged on a cryo-EM imaging scaffold | 分子名称: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Castells-Graells, R, Sawaya, M.R, Yeates, T.O. | 登録日 | 2023-02-08 | 公開日 | 2023-08-09 | 最終更新日 | 2023-09-27 | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | 主引用文献 | Cryo-EM structure determination of small therapeutic protein targets at 3 angstrom -resolution using a rigid imaging scaffold. Proc.Natl.Acad.Sci.USA, 120, 2023
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8G4F
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![BU of 8g4f by Molmil](/molmil-images/mine/8g4f) | KRAS G12V complex with GDP imaged on a cryo-EM imaging scaffold | 分子名称: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Castells-Graells, R, Sawaya, M.R, Yeates, T.O. | 登録日 | 2023-02-09 | 公開日 | 2023-08-09 | 最終更新日 | 2023-09-27 | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | 主引用文献 | Cryo-EM structure determination of small therapeutic protein targets at 3 angstrom -resolution using a rigid imaging scaffold. Proc.Natl.Acad.Sci.USA, 120, 2023
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8U0V
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![BU of 8u0v by Molmil](/molmil-images/mine/8u0v) | S. cerevisiae Pex1/Pex6 with 1 mM ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Peroxisomal ATPase PEX1, Peroxisomal ATPase PEX6 | 著者 | Gardner, B.M. | 登録日 | 2023-08-29 | 公開日 | 2023-12-13 | 最終更新日 | 2024-01-10 | 実験手法 | ELECTRON MICROSCOPY (3.89 Å) | 主引用文献 | The N1 domain of the peroxisomal AAA-ATPase Pex6 is required for Pex15 binding and proper assembly with Pex1. J.Biol.Chem., 300, 2023
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1AID
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![BU of 1aid by Molmil](/molmil-images/mine/1aid) | STRUCTURE OF A NON-PEPTIDE INHIBITOR COMPLEXED WITH HIV-1 PROTEASE: DEVELOPING A CYCLE OF STRUCTURE-BASED DRUG DESIGN | 分子名称: | 4-(4-CHLORO-PHENYL)-1-{3-[2-(4-FLUORO-PHENYL)-[1,3]DITHIOLAN-2-YL]-PROPYL}-PIPERIDIN-4-OL, CHLORIDE ION, HUMAN IMMUNODEFICIENCY VIRUS PROTEASE | 著者 | Rutenber, E.E, Fauman, E.B, Keenan, R.J, Stroud, R.M. | 登録日 | 1997-04-16 | 公開日 | 1997-10-15 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of a non-peptide inhibitor complexed with HIV-1 protease. Developing a cycle of structure-based drug design. J.Biol.Chem., 268, 1993
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3HTX
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![BU of 3htx by Molmil](/molmil-images/mine/3htx) | Crystal structure of small RNA methyltransferase HEN1 | 分子名称: | 5'-R(*GP*AP*UP*UP*UP*CP*UP*CP*UP*CP*UP*GP*CP*AP*AP*GP*CP*GP*AP*AP*AP*G)-3', 5'-R(P*UP*UP*CP*GP*CP*UP*UP*GP*CP*AP*GP*AP*GP*AP*GP*AP*AP*AP*UP*CP*AP*C)-3', HEN1, ... | 著者 | Huang, Y, Ji, L.-J, Huang, Q.-C, Vassylyev, D.G, Chen, X.-M, Ma, J.-B. | 登録日 | 2009-06-12 | 公開日 | 2009-09-29 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural insights into mechanisms of the small RNA methyltransferase HEN1. Nature, 461, 2009
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4YAG
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![BU of 4yag by Molmil](/molmil-images/mine/4yag) | Crystal structure of LigL in complex with NADH from Sphingobium sp. strain SYK-6 | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, C alpha-dehydrogenase | 著者 | Pereira, J.H, McAndrew, R.P, Heins, R.A, Sale, K.L, Simmons, B.A, Adams, P.D. | 登録日 | 2015-02-17 | 公開日 | 2016-03-09 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural and Biochemical Characterization of the Early and Late Enzymes in the Lignin beta-Aryl Ether Cleavage Pathway from Sphingobium sp. SYK-6. J.Biol.Chem., 291, 2016
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8GE0
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4YBK
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![BU of 4ybk by Molmil](/molmil-images/mine/4ybk) | C-Helix-Out Dasatinib Analog Crystallized with c-Src Kinase | 分子名称: | 2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-N-(4-phenoxyphenyl)-1,3-thiazole-5-carboxamide, Proto-oncogene tyrosine-protein kinase Src | 著者 | Kwarcinski, F.E, Brandvold, K.B, Johnson, T.K, Phadke, S, Meagher, J.L, Seeliger, M.A, Stuckey, J.A, Soellner, M.B. | 登録日 | 2015-02-18 | 公開日 | 2016-03-02 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity. Acs Chem.Biol., 11, 2016
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5E3K
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![BU of 5e3k by Molmil](/molmil-images/mine/5e3k) | Crystal structure of the ornithine aminotransferase from Toxoplasma gondii ME49 in a complex with (S)-4-amino-5-fluoropentanoic acid | 分子名称: | 4-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)amino]pent-4-enoic acid, Aminotransferase, CARBONATE ION, ... | 著者 | Filippova, E.V, Minasov, G, Flores, K, Le, H.V, Silverman, R.B, McLeod, R.L, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2015-10-02 | 公開日 | 2016-10-26 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal structure of the ornithine aminotransferase from Toxoplasma gondii ME49 in a complex with (S)-4-amino-5-fluoropentanoic acid To Be Published
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6N48
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![BU of 6n48 by Molmil](/molmil-images/mine/6n48) | Structure of beta2 adrenergic receptor bound to BI167107, Nanobody 6B9, and a positive allosteric modulator | 分子名称: | (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, Camelid Antibody Fragment, ... | 著者 | Liu, X, Masoudi, A, Kahsai, A.W, Huang, L.Y, Pani, B, Hirata, K, Ahn, S, Lefkowitz, R.J, Kobilka, B.K. | 登録日 | 2018-11-17 | 公開日 | 2019-06-26 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Mechanism of beta2AR regulation by an intracellular positive allosteric modulator. Science, 364, 2019
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6C1W
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![BU of 6c1w by Molmil](/molmil-images/mine/6c1w) | A tethered niacin-derived pincer complex with a nickel-carbon or sulfite-carbon bond in lactate racemase | 分子名称: | (4S)-5-methanethioyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-4-sulfo-1,4-dihydropyridine-3-carbothioic S-acid, 3-methanethioyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium, Lactate racemase, ... | 著者 | Fellner, M, Desguin, B, Hausinger, R.P, Hu, J. | 登録日 | 2018-01-05 | 公開日 | 2018-03-14 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.398 Å) | 主引用文献 | Lactate Racemase Nickel-Pincer Cofactor Operates by a Proton-Coupled Hydride Transfer Mechanism. Biochemistry, 57, 2018
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1AMY
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8UJY
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![BU of 8ujy by Molmil](/molmil-images/mine/8ujy) | Crystal structure of human WD repeat-containing protein 5 in complex with 4-(3,5-dimethoxybenzyl)-9-(4-fluoro-2-methylphenyl)-7-((2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl)methyl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one (compound 8) | 分子名称: | (9P)-4-[(3,5-dimethoxyphenyl)methyl]-9-(4-fluoro-2-methylphenyl)-7-{[(2E)-2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl]methyl}-3,4-dihydro-1,4-benzoxazepin-5(2H)-one, WD repeat-containing protein 5 | 著者 | Zhao, B, Amporndanai, K, Fesik, S.W. | 登録日 | 2023-10-11 | 公開日 | 2023-12-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Structure-Based Discovery of Potent, Orally Bioavailable Benzoxazepinone-Based WD Repeat Domain 5 Inhibitors. J.Med.Chem., 66, 2023
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6VMH
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5M06
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![BU of 5m06 by Molmil](/molmil-images/mine/5m06) | Crystal structure of Mycobacterium tuberculosis PknI kinase domain | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Serine/threonine-protein kinase PknI | 著者 | Wagner, T, Lisa, M.N, Alexandre, M, Barilone, N, Raynal, B, Alzari, P.M, Bellinzoni, M. | 登録日 | 2016-10-03 | 公開日 | 2017-01-11 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase-like conformation. FEBS J., 284, 2017
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5M07
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![BU of 5m07 by Molmil](/molmil-images/mine/5m07) | Crystal structure of Mycobacterium tuberculosis PknI kinase domain, C20A mutant | 分子名称: | SODIUM ION, Serine/threonine-protein kinase PknI | 著者 | Lisa, M.N, Wagner, T, Alexandre, M, Barilone, N, Raynal, B, Alzari, P.M, Bellinzoni, M. | 登録日 | 2016-10-03 | 公開日 | 2017-01-11 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase-like conformation. FEBS J., 284, 2017
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5M09
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![BU of 5m09 by Molmil](/molmil-images/mine/5m09) | Crystal structure of Mycobacterium tuberculosis PknI kinase domain, C20A_R136N double mutant | 分子名称: | SODIUM ION, Serine/threonine-protein kinase PknI | 著者 | Lisa, M.N, Wagner, T, Alexandre, M, Barilone, N, Raynal, B, Alzari, P.M, Bellinzoni, M. | 登録日 | 2016-10-03 | 公開日 | 2017-01-11 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | 主引用文献 | The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase-like conformation. FEBS J., 284, 2017
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7LNY
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7TIM
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![BU of 7tim by Molmil](/molmil-images/mine/7tim) | STRUCTURE OF THE TRIOSEPHOSPHATE ISOMERASE-PHOSPHOGLYCOLOHYDROXAMATE COMPLEX: AN ANALOGUE OF THE INTERMEDIATE ON THE REACTION PATHWAY | 分子名称: | PHOSPHOGLYCOLOHYDROXAMIC ACID, TRIOSEPHOSPHATE ISOMERASE | 著者 | Davenport, R.C, Bash, P.A, Seaton, B.A, Karplus, M, Petsko, G.A, Ringe, D. | 登録日 | 1991-04-23 | 公開日 | 1993-10-31 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure of the triosephosphate isomerase-phosphoglycolohydroxamate complex: an analogue of the intermediate on the reaction pathway. Biochemistry, 30, 1991
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7LO0
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![BU of 7lo0 by Molmil](/molmil-images/mine/7lo0) | Structure of human ASF1a in complex with a TLK2 peptide | 分子名称: | Histone chaperone ASF1A, Serine/threonine-protein kinase tousled-like 2 | 著者 | Simon, B, Calderwood, D, Turk, B.E, Boggon, T.J. | 登録日 | 2021-02-08 | 公開日 | 2022-02-16 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | 主引用文献 | Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry. Nat Commun, 13, 2022
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