PDB: 45953 件ウェブページステータス検索Chemie searchBIRD

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5KTV	Mis-pairing of unnatural base Z-G DNA duplex at pH 8.5 分子名称: CALCIUM ION, DNA (5'-D(P*GP*CP*GP*AP*AP*TP*TP*(1W5)P*GP*CP*G)-3') 著者 Ahmad Sobri, A.F, Brady, R.L. 登録日 2016-07-12 公開日 2017-05-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structural Basis of the Mispairing of an Artificially Expanded Genetic Information System Chemistry, 2017
6JNX	Cryo-EM structure of a Q-engaged arrested complex 分子名称: Antiterminator Q protein, DNA (63-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Feng, Y, Shi, J. 登録日 2019-03-18 公開日 2019-06-12 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.08 Å) 主引用文献 Structural basis of Q-dependent transcription antitermination. Nat Commun, 10, 2019
5D4C	Crystal structure of Thermus thermophilus product complex for transcription initiation with ATP and CTP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CYTIDINE-5'-MONOPHOSPHATE, CYTIDINE-5'-TRIPHOSPHATE, ... 著者 Zhang, Y, Ebright, R.H. 登録日 2015-08-07 公開日 2016-07-06 最終更新日 2024-07-03 実験手法 X-RAY DIFFRACTION (3.28 Å) 主引用文献 The mechanism of RNA 5' capping with NAD(+), NADH and desphospho-CoA. Nature, 535, 2016
4KN4	X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Benzoxazinorifamycin-2b 分子名称: Benzoxazinorifamycin-2b, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Murakami, K.S. 登録日 2013-05-08 公開日 2013-05-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.965 Å) 主引用文献 X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins. J.Med.Chem., 56, 2013
4Q4Z	Thermus thermophilus RNA polymerase de novo transcription initiation complex 分子名称: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, ADENOSINE-5'-TRIPHOSPHATE, DNA (25-MER), ... 著者 Murakami, K.S. 登録日 2014-04-15 公開日 2014-07-30 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis of transcription initiation by bacterial RNA polymerase holoenzyme. J.Biol.Chem., 289, 2014
4KN7	X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Benzoxazinorifamycin-2c 分子名称: Benzoxazinorifamycin-2c, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Murakami, K.S. 登録日 2013-05-08 公開日 2013-05-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.686 Å) 主引用文献 X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins. J.Med.Chem., 56, 2013
4Q5S	Thermus thermophilus RNA polymerase initially transcribing complex containing 6-mer RNA 分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*GP*CP*AP*GP*CP*CP*A)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3'), ... 著者 Murakami, K.S. 登録日 2014-04-17 公開日 2014-07-09 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis of transcription initiation by bacterial RNA polymerase holoenzyme. J.Biol.Chem., 289, 2014
6RH3	Cryo-EM structure of E. coli RNA polymerase elongation complex bound to CTP substrate 分子名称: CYTIDINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Abdelkareem, M, Saint-Andre, C, Takacs, M, Papai, G, Crucifix, C, Guo, X, Ortiz, J, Weixlbaumer, A. 登録日 2019-04-18 公開日 2019-07-03 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural Basis of Transcription: RNA Polymerase Backtracking and Its Reactivation. Mol.Cell, 75, 2019
8WMH	Structure of CbCas9 bound to 6-nucleotide complementary DNA substrate 分子名称: NTS, TS, deadCbCas9, ... 著者 Zhang, S, Lin, S, Liu, J.J.G. 登録日 2023-10-03 公開日 2024-06-05 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity. Nature, 630, 2024
8WMM	Structure of CbCas9-PcrIIC1 complex bound to 28-bp DNA substrate (20-nt complementary) 分子名称: MAGNESIUM ION, NTS, PcrIIC1, ... 著者 Zhang, S, Lin, S, Liu, J.J.G. 登録日 2023-10-04 公開日 2024-06-05 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (2.98 Å) 主引用文献 Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity. Nature, 630, 2024
7Z2Z	Structure of yeast RNA Polymerase III-DNA-Ty1 integrase complex (Pol III-DNA-IN1) at 3.1 A 分子名称: (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-pentan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7,12-triol, DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ... 著者 Nguyen, P.Q, Fernandez-Tornero, C. 登録日 2022-03-01 公開日 2023-04-05 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3.07 Å) 主引用文献 Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration. Nat Commun, 14, 2023
4LLG	Crystal Structure Analysis of the E.coli holoenzyme/Gp2 complex 分子名称: Bacterial RNA polymerase inhibitor, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Bae, B, Darst, S.A. 登録日 2013-07-09 公開日 2013-11-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.7936 Å) 主引用文献 Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of sigma 70 domain 1.1. Proc.Natl.Acad.Sci.USA, 110, 2013
9C9M	HIV-1 intasome core bound with DTG 分子名称: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, Integrase, MAGNESIUM ION, ... 著者 Li, M, Craigie, R. 登録日 2024-06-14 公開日 2024-07-31 最終更新日 2024-08-07 実験手法 ELECTRON MICROSCOPY (2.01 Å) 主引用文献 HIV-1 Intasomes Assembled with Excess Integrase C-Terminal Domain Protein Facilitate Structural Studies by Cryo-EM and Reveal the Role of the Integrase C-Terminal Tail in HIV-1 Integration. Viruses, 16, 2024
8YGJ	SpCas9-MMLV RT-pegRNA-target DNA complex (elongation 28-nt) 分子名称: CRISPR-associated endonuclease Cas9/Csn1, DNA (5'-D(P*TP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*TP*AP*CP*TP*AP*G)-3'), DNA (51-MER), ... 著者 Shuto, Y, Nakagawa, R, Hoki, M, Omura, S.N, Hirano, H, Itoh, Y, Nureki, O. 登録日 2024-02-26 公開日 2024-06-05 最終更新日 2024-09-04 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural basis for pegRNA-guided reverse transcription by a prime editor Nature, 631, 2024
8WUS	SpCas9-MMLV RT-pegRNA-target DNA complex (termination) 分子名称: CRISPR-associated endonuclease Cas9/Csn1, DNA (40-MER), DNA (5'-D(*TP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*TP*AP*CP*TP*AP*G)-3'), ... 著者 Shuto, Y, Nakagawa, R, Hoki, M, Omura, S.N, Hirano, H, Itoh, Y, Nureki, O. 登録日 2023-10-21 公開日 2024-06-05 最終更新日 2024-09-04 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural basis for pegRNA-guided reverse transcription by a prime editor Nature, 631, 2024
8WUV	SpCas9-MMLV RT-pegRNA-target DNA complex (elongation 16-nt) 分子名称: CRISPR-associated endonuclease Cas9/Csn1, DNA (5'-D(*TP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*TP*AP*CP*TP*AP*G)-3'), DNA (50-MER), ... 著者 Shuto, Y, Nakagawa, R, Hoki, M, Omura, S.N, Hirano, H, Itoh, Y, Nureki, O. 登録日 2023-10-21 公開日 2024-06-05 最終更新日 2024-09-04 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural basis for pegRNA-guided reverse transcription by a prime editor Nature, 631, 2024
8WUU	SpCas9-pegRNA-target DNA complex (pre-initiation) 分子名称: CRISPR-associated endonuclease Cas9/Csn1, DNA (34-MER), DNA (5'-D(*TP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*TP*AP*CP*TP*AP*G)-3'), ... 著者 Shuto, Y, Nakagawa, R, Hoki, M, Omura, S.N, Hirano, H, Itoh, Y, Nureki, O. 登録日 2023-10-21 公開日 2024-06-05 最終更新日 2024-09-04 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural basis for pegRNA-guided reverse transcription by a prime editor Nature, 631, 2024
4G7Z	Crystal structure of Thermus thermophilus transcription initiation complex containing 5-BrU at template-strand position +1 分子名称: 5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*(BRU)P*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', DNA-directed RNA polymerase subunit alpha, ... 著者 Zhang, Y, Ebright, R.H. 登録日 2012-07-20 公開日 2012-10-31 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.815 Å) 主引用文献 Structural basis of transcription initiation. Science, 338, 2012
4G7H	Crystal structure of Thermus thermophilus transcription initiation complex 分子名称: 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', DNA-directed RNA polymerase subunit alpha, ... 著者 Zhang, Y, Ebright, R.H. 登録日 2012-07-20 公開日 2012-10-31 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis of transcription initiation. Science, 338, 2012
4G7O	Crystal structure of Thermus thermophilus transcription initiation complex containing 2 nt of RNA 分子名称: 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', 5'-R(*GP*A)-3', ... 著者 Zhang, Y, Ebright, R.H. 登録日 2012-07-20 公開日 2012-10-31 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.993 Å) 主引用文献 Structural basis of transcription initiation. Science, 338, 2012
5W4E	Importin binding to Tdt NLS peptide 分子名称: GLYCEROL, Importin subunit alpha-1,Importin subunit alpha-1, human DNA repair polymerase Tdt 著者 Pedersen, L.C, London, R. 登録日 2017-06-10 公開日 2018-06-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 Variations in nuclear localization strategies among pol X family enzymes. Traffic, 2018
8PAT	Structure of the E.coli DNA polymerase sliding clamp with a covalently bound peptide 3. 分子名称: ACE-GLN-ALC-GLX-LEU-PHE, Beta sliding clamp 著者 Compain, G, Monsarrat, C, Blagojevic, J, Brillet, K, Dumas, P, Hammann, P, Kuhn, L, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Burnouf, D, Guichard, G. 登録日 2023-06-08 公開日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Peptide-Based Covalent Inhibitors Bearing Mild Electrophiles to Target a Conserved His Residue of the Bacterial Sliding Clamp. Jacs Au, 4, 2024
7SSA	Cryo-EM structure of pioneer factor Cbf1 bound to the nucleosome 分子名称: Centromere-binding protein 1, DNA (137-MER), Histone H2A.1, ... 著者 Eek, P, Tan, S. 登録日 2021-11-10 公開日 2023-04-05 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Basic helix-loop-helix pioneer factors interact with the histone octamer to invade nucleosomes and generate nucleosome-depleted regions. Mol.Cell, 83, 2023
6NMI	Cryo-EM structure of the human TFIIH core complex 分子名称: CDK-activating kinase assembly factor MAT1, General transcription and DNA repair factor IIH helicase subunit XPB, General transcription and DNA repair factor IIH helicase subunit XPD, ... 著者 Greber, B.J, Toso, D, Fang, J, Nogales, E. 登録日 2019-01-10 公開日 2019-03-13 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 The complete structure of the human TFIIH core complex. Elife, 8, 2019
6NSR	TetR family transcriptional regulator CifR C99T-C181R cysteine mutant complexed with 26bp double-strand operator DNA and apo-CifR C99T-C181R 分子名称: CifR, DNA (26-MER) 著者 He, S, Taher, N.M, Simard, A.R, Madden, D.R. 登録日 2019-01-25 公開日 2020-01-29 最終更新日 2024-07-17 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Molecular basis for the transcriptional regulation of an epoxide-based virulence circuit in Pseudomonas aeruginosa Biorxiv, 2024

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