5KBU
| Cryo-EM structure of GluA2-2xSTZ complex at 7.8 Angstrom resolution | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid | 著者 | Twomey, E.C, Yelshanskaya, M.V, Grassucci, R.A, Frank, J, Sobolevsky, A.I. | 登録日 | 2016-06-03 | 公開日 | 2016-07-13 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (7.8 Å) | 主引用文献 | Elucidation of AMPA receptor-stargazin complexes by cryo-electron microscopy. Science, 353, 2016
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5LZK
| Structure of the domain of unknown function DUF1669 from human FAM83B | 分子名称: | 1,2-ETHANEDIOL, IODIDE ION, Protein FAM83B | 著者 | Pinkas, D.M, Bufton, J.C, Williams, E.P, Shrestha, L, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC) | 登録日 | 2016-09-29 | 公開日 | 2016-10-26 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.575 Å) | 主引用文献 | Structure of the domain of unknown function DUF1669 from human FAM83B To Be Published
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5K0K
| Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC2434 | 分子名称: | 15-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-4,5,6,7,9,10,11,12-octahydro-2,16-(azenometheno)pyrrolo[2,1-d][1,3,5,9]te traazacyclotetradecin-8(3H)-one, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Wang, X, Liu, J, Zhang, W, Stashko, M.A, Nichols, J, DeRyckere, D, Miley, M.J, Norris-Drouin, J, Chen, Z, Machius, M, Wood, E, Graham, D.K, Earp, H.S, Graham, K, Kireev, D, Frye, S.V. | 登録日 | 2016-05-17 | 公開日 | 2017-01-11 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.545 Å) | 主引用文献 | Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors. ACS Med Chem Lett, 7, 2016
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5K0X
| Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC2541 | 分子名称: | (7S)-7-amino-N-[(4-fluorophenyl)methyl]-8-oxo-2,9,16,18,21-pentaazabicyclo[15.3.1]henicosa-1(21),17,19-triene-20-carboxamide, CHLORIDE ION, Tyrosine-protein kinase Mer | 著者 | McIver, A.L, Zhang, W, Liu, Q, Jiang, X, Stashko, M.A, Nichols, J, Miley, M.J, Norris-Drouin, J, Machius, M, DeRyckere, D, Wood, E, Graham, D.K, Earp, H.S, Kireev, D, Frye, S.V, Wang, X. | 登録日 | 2016-05-17 | 公開日 | 2017-02-22 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.231 Å) | 主引用文献 | Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors. ChemMedChem, 12, 2017
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6H5W
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5LVO
| Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the PIF-Pocket | 分子名称: | 2-oxidanylidenepropyl ~{N}-(2-chloranyl-6-fluoranyl-phenyl)carbonyl-~{N}'-(4-chlorophenyl)carbamimidothioate, 3-phosphoinositide-dependent protein kinase 1, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Schulze, J.O, Saladino, G, Busschots, K, Neimanis, S, Suess, E, Odadzic, D, Zeuzem, S, Hindie, V, Herbrand, A.K, Lisa, M.N, Alzari, P.M, Gervasio, F.L, Biondi, R.M. | 登録日 | 2016-09-14 | 公開日 | 2016-10-19 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.09 Å) | 主引用文献 | Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase. Cell Chem Biol, 23, 2016
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6SD4
| Structure of the RBM3/collar region of the Salmonella flagella MS-ring protein FliF with 34-fold symmetry applied | 分子名称: | Flagellar M-ring protein | 著者 | Johnson, S, Fong, Y.H, Deme, J.C, Furlong, E.J, Kuhlen, L, Lea, S.M. | 登録日 | 2019-07-26 | 公開日 | 2020-03-18 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Symmetry mismatch in the MS-ring of the bacterial flagellar rotor explains the structural coordination of secretion and rotation. Nat Microbiol, 5, 2020
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8TTU
| Structure of SNX27 FERM complexed with Fam21A repeat 19 (1261 - 1274) | 分子名称: | DI(HYDROXYETHYL)ETHER, Fam21A repeat 19 peptide, GLYCEROL, ... | 著者 | Guo, Q, Chen, K.-E, Collins, B.M. | 登録日 | 2023-08-15 | 公開日 | 2024-08-21 | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | 主引用文献 | Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complex. Proc.Natl.Acad.Sci.USA, 121, 2024
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6MAV
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5LWZ
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8TTV
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8TTC
| Structure of retromer VPS29-VPS35 (483-796) complexed with Fam21A repeat 20 (1289-1302) | 分子名称: | ACETATE ION, CITRIC ACID, DI(HYDROXYETHYL)ETHER, ... | 著者 | Chen, K.-E, Guo, Q, Collins, B.M. | 登録日 | 2023-08-13 | 公開日 | 2024-08-21 | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | 主引用文献 | Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complex. Proc.Natl.Acad.Sci.USA, 121, 2024
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5KE3
| Crystal structure of SETDB1 Tudor domain in complex with fragment MRT0181a | 分子名称: | (S)-N-(furan-2-ylmethyl)-1-(1,2,3,4-tetrahydroisoquinoline-3-carbonyl)piperidine-4-carboxamide, BETA-MERCAPTOETHANOL, Histone-lysine N-methyltransferase SETDB1, ... | 著者 | Dong, A, Iqbal, A, Mader, P, Dobrovetsky, E, Ferreira de Freitas, R, Walker, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Schapira, M, Brown, P.J, Structural Genomics Consortium (SGC) | 登録日 | 2016-06-09 | 公開日 | 2016-08-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal structure of SETDB1 Tudor domain in complex with fragment MRT0181a to be published
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6BNB
| Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET57 PROTAC | 分子名称: | Bromodomain-containing protein 4, DNA damage-binding protein 1, Protein cereblon, ... | 著者 | Nowak, R.P, DeAngelo, S.L, Buckley, D, Ishoey, M, He, Z, Zhang, T, Bradner, J.E, Fischer, E.S. | 登録日 | 2017-11-16 | 公開日 | 2018-05-30 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (6.343 Å) | 主引用文献 | Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat. Chem. Biol., 14, 2018
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5M33
| Structural tuning of CD81LEL (space group P21) | 分子名称: | 1,2-ETHANEDIOL, CD81 antigen | 著者 | Cunha, E.S, Sfriso, P, Rojas, A.L, Roversi, P, Hospital, A, Orozco, M, Abrescia, N.G. | 登録日 | 2016-10-14 | 公開日 | 2016-12-14 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | 主引用文献 | Mechanism of Structural Tuning of the Hepatitis C Virus Human Cellular Receptor CD81 Large Extracellular Loop. Structure, 25, 2017
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5M38
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8KAD
| Crystal structure of an antibody light chain tetramer with 3D domain swapping | 分子名称: | Antibody light chain | 著者 | Sakai, T, Mashima, T, Kobayashi, N, Ogata, H, Uda, T, Hifumi, E, Hirota, S. | 登録日 | 2023-08-02 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural and thermodynamic insights into antibody light chain tetramer formation through 3D domain swapping. Nat Commun, 14, 2023
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5K3C
| Crystal Structure of the Fluoroacetate Dehalogenase RPA1163 - WT/5-Fluorotryptophan | 分子名称: | CHLORIDE ION, Fluoroacetate dehalogenase | 著者 | Mehrabi, P, Kim, T.H, Prosser, S.R, Pai, E.F. | 登録日 | 2016-05-19 | 公開日 | 2017-02-01 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.541 Å) | 主引用文献 | The role of dimer asymmetry and protomer dynamics in enzyme catalysis. Science, 355, 2017
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5M3T
| Structural tuning of CD81LEL (space group P64) | 分子名称: | 1,2-ETHANEDIOL, CD81 antigen, CHLORIDE ION | 著者 | Cunha, E.S, Sfriso, P, Rojas, A.L, Roversi, P, Hospital, A, Orozco, M, Abrescia, N.G. | 登録日 | 2016-10-17 | 公開日 | 2016-12-14 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.021 Å) | 主引用文献 | Mechanism of Structural Tuning of the Hepatitis C Virus Human Cellular Receptor CD81 Large Extracellular Loop. Structure, 25, 2017
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5KEP
| High resolution cryo-EM maps of Human Papillomavirus 16 reveal L2 location and heparin-induced conformational changes | 分子名称: | Major capsid protein L1 | 著者 | Guan, J, Bywaters, S.M, Brendle, S.A, Ashley, R.E, Makhov, A.M, Conway, J.F, Christensen, N.D, Hafenstein, S. | 登録日 | 2016-06-10 | 公開日 | 2017-01-25 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Cryoelectron Microscopy Maps of Human Papillomavirus 16 Reveal L2 Densities and Heparin Binding Site. Structure, 25, 2017
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8TK3
| HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) having oxidized catalytic cysteine and complexed with 6-(difluoromethyl)pyrimidin-4-ol at two allosteric sites | 分子名称: | 6-(difluoromethyl)pyrimidin-4-ol, DIMETHYL SULFOXIDE, Dual specificity protein phosphatase 3 | 著者 | Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. | 登録日 | 2023-07-25 | 公開日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) having oxidized catalytic cysteine and complexed with 6-(difluoromethyl)pyrimidin-4-ol at two allosteric sites To Be Published
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6LR6
| The crystal structure of human cytoplasmic LRS | 分子名称: | 4-Chloro-3-aminomethyl-7-[ethoxy]-3H-benzo[C][1,2]oxaborol-1-ol modified adenosine, 5'-O-(L-leucylsulfamoyl)adenosine, Leucine--tRNA ligase, ... | 著者 | Liu, R.J, Long, T, Li, H, Li, J, Zhao, J.H, Lin, J.Z, Palencia, A, Wang, M.Z, Cusack, S, Wang, E.D. | 登録日 | 2020-01-15 | 公開日 | 2020-03-25 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.009 Å) | 主引用文献 | Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond. Nucleic Acids Res., 48, 2020
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6MEJ
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8TK2
| HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) complexed with 2-((2,4-difluorobenzyl)amino)-2-oxoacetic acid | 分子名称: | DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, Dual specificity protein phosphatase 3, ... | 著者 | Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. | 登録日 | 2023-07-25 | 公開日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) binding 2-((2,4-difluorobenzyl)amino)-2-oxoacetic acid To Be Published
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6SCI
| Structure of AdhE form 1 | 分子名称: | Aldehyde-alcohol dehydrogenase, FE (III) ION | 著者 | Lovering, A.L, Bragginton, E. | 登録日 | 2019-07-24 | 公開日 | 2020-08-26 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | High-resolution structure of the alcohol dehydrogenase domain of the bifunctional bacterial enzyme AdhE. Acta Crystallogr.,Sect.F, 76, 2020
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