6LR6

The crystal structure of human cytoplasmic LRS

Summary for 6LR6

Entry DOI	10.2210/pdb6lr6/pdb
Descriptor	Leucine--tRNA ligase, cytoplasmic, 5'-O-(L-leucylsulfamoyl)adenosine, 4-Chloro-3-aminomethyl-7-[ethoxy]-3H-benzo[C][1,2]oxaborol-1-ol modified adenosine, ... (4 entities in total)
Functional Keywords	trna, aminoacylation, protein translation, leurs, rna binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	252431.73
Authors	Liu, R.J.,Long, T.,Li, H.,Li, J.,Zhao, J.H.,Lin, J.Z.,Palencia, A.,Wang, M.Z.,Cusack, S.,Wang, E.D. (deposition date: 2020-01-15, release date: 2020-03-25, Last modification date: 2023-11-29)
Primary citation	Liu, R.J.,Long, T.,Li, H.,Zhao, J.,Li, J.,Wang, M.,Palencia, A.,Lin, J.,Cusack, S.,Wang, E.D. Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond. Nucleic Acids Res., 48:4946-4959, 2020 Cited by PubMed: 32232361 DOI: 10.1093/nar/gkaa189 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.009 Å)

Structure validation