6LR6
The crystal structure of human cytoplasmic LRS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0002161 | molecular_function | aminoacyl-tRNA deacylase activity |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004819 | molecular_function | glutamine-tRNA ligase activity |
| A | 0004823 | molecular_function | leucine-tRNA ligase activity |
| A | 0005096 | molecular_function | GTPase activator activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005764 | cellular_component | lysosome |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006425 | biological_process | glutaminyl-tRNA aminoacylation |
| A | 0006429 | biological_process | leucyl-tRNA aminoacylation |
| A | 0012505 | cellular_component | endomembrane system |
| A | 0016604 | cellular_component | nuclear body |
| A | 0016874 | molecular_function | ligase activity |
| A | 0017101 | cellular_component | aminoacyl-tRNA synthetase multienzyme complex |
| A | 0034198 | biological_process | cellular response to amino acid starvation |
| A | 0071230 | biological_process | cellular response to amino acid stimulus |
| A | 0071233 | biological_process | cellular response to L-leucine |
| A | 0106074 | biological_process | aminoacyl-tRNA metabolism involved in translational fidelity |
| A | 1904263 | biological_process | positive regulation of TORC1 signaling |
| A | 1990253 | biological_process | cellular response to leucine starvation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0002161 | molecular_function | aminoacyl-tRNA deacylase activity |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004819 | molecular_function | glutamine-tRNA ligase activity |
| B | 0004823 | molecular_function | leucine-tRNA ligase activity |
| B | 0005096 | molecular_function | GTPase activator activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005764 | cellular_component | lysosome |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005829 | cellular_component | cytosol |
| B | 0006412 | biological_process | translation |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006425 | biological_process | glutaminyl-tRNA aminoacylation |
| B | 0006429 | biological_process | leucyl-tRNA aminoacylation |
| B | 0012505 | cellular_component | endomembrane system |
| B | 0016604 | cellular_component | nuclear body |
| B | 0016874 | molecular_function | ligase activity |
| B | 0017101 | cellular_component | aminoacyl-tRNA synthetase multienzyme complex |
| B | 0034198 | biological_process | cellular response to amino acid starvation |
| B | 0071230 | biological_process | cellular response to amino acid stimulus |
| B | 0071233 | biological_process | cellular response to L-leucine |
| B | 0106074 | biological_process | aminoacyl-tRNA metabolism involved in translational fidelity |
| B | 1904263 | biological_process | positive regulation of TORC1 signaling |
| B | 1990253 | biological_process | cellular response to leucine starvation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue LSS A 1200 |
| Chain | Residue |
| A | PHE50 |
| A | HIS251 |
| A | LEU594 |
| A | SER597 |
| A | SER673 |
| A | GLY674 |
| A | ASP676 |
| A | LEU677 |
| A | HIS681 |
| A | HIS709 |
| A | LEU710 |
| A | PRO51 |
| A | TYR52 |
| A | PRO53 |
| A | TYR54 |
| A | GLY62 |
| A | HIS63 |
| A | SER66 |
| A | HIS91 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue A2H A 1201 |
| Chain | Residue |
| A | ALA292 |
| A | THR293 |
| A | LEU294 |
| A | THR298 |
| A | ILE380 |
| A | LYS381 |
| A | LYS384 |
| A | VAL389 |
| A | THR390 |
| A | VAL392 |
| A | ASP395 |
| A | SER396 |
| A | ASP399 |
| A | LYS464 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | binding site for residue LSS B 1200 |
| Chain | Residue |
| B | PHE50 |
| B | PRO51 |
| B | TYR52 |
| B | PRO53 |
| B | TYR54 |
| B | GLY62 |
| B | HIS63 |
| B | SER66 |
| B | HIS91 |
| B | HIS251 |
| B | LEU594 |
| B | SER597 |
| B | SER673 |
| B | GLY674 |
| B | ASP676 |
| B | HIS681 |
| B | HIS709 |
| B | LEU710 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | binding site for residue A2H B 1201 |
| Chain | Residue |
| B | TYR264 |
| B | THR293 |
| B | LEU294 |
| B | ARG295 |
| B | THR298 |
| B | ILE380 |
| B | LYS381 |
| B | LYS384 |
| B | VAL389 |
| B | THR390 |
| B | VAL392 |
| B | SER396 |
| B | ASP399 |
| B | LYS464 |
Functional Information from PROSITE/UniProt
| site_id | PS00178 |
| Number of Residues | 12 |
| Details | AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. PymNGrLHLGHT |
| Chain | Residue | Details |
| A | PRO53-THR64 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 498 |
| Details | Region: {"description":"Editing domain","evidences":[{"source":"PubMed","id":"19426743","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Motif: {"description":"'HIGH' region","evidences":[{"source":"PubMed","id":"32232361","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6LPF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Motif: {"description":"'KMSKS' region","evidences":[{"source":"PubMed","id":"32232361","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6LPF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32232361","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6LPF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q8BMJ2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
