8PDY
 
 | | E. coli RNA polymerase paused at ops site | | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | 著者 | Zuber, P.K, Said, N, Hilal, T, Loll, B, Wahl, M.C, Knauer, S.H. | | 登録日 | 2023-06-13 | | 公開日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Concerted transformation of a hyper-paused transcription complex and its reinforcing protein.
Nat Commun, 15, 2024
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8PH9
 | | E. coli RNA polymerase paused at ops site (non-complementary scaffold) | | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | 著者 | Zuber, P.K, Said, N, Hilal, T, Loll, B, Wahl, M.C, Knauer, S.H. | | 登録日 | 2023-06-19 | | 公開日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Concerted transformation of a hyper-paused transcription complex and its reinforcing protein.
Nat Commun, 15, 2024
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2Q66
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5N9J
 | | Core Mediator of transcriptional regulation | | 分子名称: | Mediator Complex Subunit 9, Mediator of RNA polymerase II transcription subunit 10, Mediator of RNA polymerase II transcription subunit 11, ... | | 著者 | Nozawa, K, Schneider, T.R, Cramer, P. | | 登録日 | 2017-02-25 | | 公開日 | 2017-05-17 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Core Mediator structure at 3.4 Angstrom extends model of transcription initiation complex.
Nature, 545, 2017
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6CCE
 | | Crystal structure of a Mycobacterium smegmatis RNA polymerase transcription initiation complex with inhibitor Kanglemycin A | | 分子名称: | 1,2-ETHANEDIOL, DNA (57-MER), DNA-directed RNA polymerase subunit alpha, ... | | 著者 | Lilic, M, Darst, S.A, Campbell, E.A. | | 登録日 | 2018-02-07 | | 公開日 | 2018-08-15 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | | 主引用文献 | Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism.
Nat Commun, 9, 2018
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5ZYP
 | | Structure of the Yeast Ctr9/Paf1 complex | | 分子名称: | NICKEL (II) ION, RNA polymerase-associated protein CTR9,RNA polymerase II-associated protein 1 | | 著者 | Xie, Y, Zheng, M, Zhou, H, Long, J. | | 登録日 | 2018-05-28 | | 公開日 | 2018-09-26 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.532 Å) | | 主引用文献 | Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation.
Nat Commun, 9, 2018
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8GWE
 | | SARS-CoV-2 E-RTC complex with RNA-nsp9 and GMPPNP | | 分子名称: | Helicase nsp13, MAGNESIUM ION, Non-structural protein 8, ... | | 著者 | Yan, L.M, Rao, Z.H, Lou, Z.Y. | | 登録日 | 2022-09-16 | | 公開日 | 2023-01-11 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (2.66 Å) | | 主引用文献 | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors.
Cell, 185, 2022
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8GWF
 | | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Helicase, Non-structural protein 7, ... | | 著者 | Yan, L.Y, Huang, Y.C, Rao, Z.H, Lou, Z.Y. | | 登録日 | 2022-09-17 | | 公開日 | 2023-01-11 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | | 主引用文献 | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors.
Cell, 185, 2022
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1UON
 | | REOVIRUS POLYMERASE LAMBDA-3 LOCALIZED BY ELECTRON CRYOMICROSCOPY OF VIRIONS AT 7.6-A RESOLUTION | | 分子名称: | 3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE, 5'-R(*GP*GP*GP*GP*GP*)-3', 5'-R(*UP*AP*GP*CP*CP*CP*CP*CP*)-3', ... | | 著者 | Zhang, X, Walker, S.B, Chipman, P.R, Nibert, M.L, Baker, T.S. | | 登録日 | 2003-09-21 | | 公開日 | 2003-11-13 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (7.6 Å) | | 主引用文献 | Reovirus Polymerase Lambda3 Localized by Cryo-Electron Microscopy of Virions at a Resolution of 7.6 A
Nat.Struct.Biol., 10, 2003
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5ZAM
 | | Cryo-EM structure of human Dicer and its complexes with a pre-miRNA substrate | | 分子名称: | Endoribonuclease Dicer, RISC-loading complex subunit TARBP2, RNA (73-mer) | | 著者 | Liu, Z, Wang, J, Cheng, H, Ke, X, Sun, L, Zhang, Q.C, Wang, H.-W. | | 登録日 | 2018-02-07 | | 公開日 | 2018-05-09 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (5.7 Å) | | 主引用文献 | Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate.
Cell, 173, 2018
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8GWO
 | | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors | | 分子名称: | Helicase, Non-structural protein 7, Non-structural protein 8, ... | | 著者 | Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. | | 登録日 | 2022-09-17 | | 公開日 | 2022-11-30 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors.
Cell, 185, 2022
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8GWN
 | | A mechanism for SARS-CoV-2 RNA capping and its inhibitor of AT-527 | | 分子名称: | Helicase, Non-structural protein 7, Non-structural protein 8, ... | | 著者 | Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. | | 登録日 | 2022-09-17 | | 公開日 | 2022-12-14 | | 最終更新日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | | 主引用文献 | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors.
Cell, 185, 2022
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8GWK
 | | SARS-CoV-2 RNA E-RTC complex with RMP-nsp9 and GMPPNP | | 分子名称: | Helicase, MAGNESIUM ION, Non-structural protein 7, ... | | 著者 | Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. | | 登録日 | 2022-09-17 | | 公開日 | 2024-02-28 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (2.72 Å) | | 主引用文献 | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors.
Cell, 185, 2022
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9F6D
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9F6F
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9F6E
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8QJ7
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9GUK
 | | Crystal structure of transcription factor NtcA from Synechococcus elongatus in complex with its transcriptional co- activator PipX and its target DNA (Crystal I) | | 分子名称: | 2-OXOGLUTARIC ACID, DNA (30-MER), Global nitrogen regulator, ... | | 著者 | Forcada-Nadal, A, Llacer, J.L, Rubio, V. | | 登録日 | 2024-09-19 | | 公開日 | 2025-03-12 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | Structures of the cyanobacterial nitrogen regulators NtcA and PipX complexed to DNA shed light on DNA binding by NtcA and implicate PipX in the recruitment of RNA polymerase.
Nucleic Acids Res., 53, 2025
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3VU7
 | | Crystal structure of REV1-REV7-REV3 ternary complex | | 分子名称: | DNA polymerase zeta catalytic subunit, DNA repair protein REV1, Mitotic spindle assembly checkpoint protein MAD2B | | 著者 | Kikuchi, S, Hara, K, Shimizu, T, Sato, M, Hashimoto, H. | | 登録日 | 2012-06-20 | | 公開日 | 2012-08-08 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural basis of recruitment of DNA polymerase [zeta] by interaction between REV1 and REV7 proteins
J.Biol.Chem., 287, 2012
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4OAV
 | | Complete human RNase L in complex with 2-5A (5'-ppp heptamer), AMPPCP and RNA substrate. | | 分子名称: | (2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-2-({[(S)-hydroxy{[(2R,3S,4S)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl]oxy}phosphoryl]oxy}methyl)tetrahydrofuran-3-yl dihydrogen phosphate, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | | 著者 | Han, Y, Donovan, J, Rath, S, Whitney, G, Chitrakar, A, Korennykh, A. | | 登録日 | 2014-01-06 | | 公開日 | 2014-03-12 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response.
Science, 343, 2014
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4OAU
 | | Complete human RNase L in complex with biological activators. | | 分子名称: | 2-5A-dependent ribonuclease, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Han, Y, Donovan, J, Rath, S, Whitney, G, Chitrakar, A, Korennykh, A. | | 登録日 | 2014-01-06 | | 公開日 | 2014-03-12 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response.
Science, 343, 2014
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3J7P
 | | Structure of the 80S mammalian ribosome bound to eEF2 | | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 5.8S ribosomal RNA, ... | | 著者 | Voorhees, R.M, Fernandez, I.S, Scheres, S.H.W, Hegde, R.S. | | 登録日 | 2014-08-01 | | 公開日 | 2014-09-03 | | 最終更新日 | 2024-11-20 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structure of the Mammalian ribosome-sec61 complex to 3.4 a resolution.
Cell(Cambridge,Mass.), 157, 2014
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5VO8
 | | X-ray crystal structure of a bacterial reiterative transcription complex of pyrG promoter | | 分子名称: | DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*CP*TP*GP*AP*TP*GP*CP*AP*CP*C)-3'), DNA (5'-D(P*GP*GP*TP*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*AP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... | | 著者 | Murakami, K.S, Shin, Y, Turnbough Jr, C.L, Molodtsov, V. | | 登録日 | 2017-05-02 | | 公開日 | 2017-05-24 | | 最終更新日 | 2024-12-25 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathway.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5ZAL
 | | Cryo-EM structure of human Dicer and its complexes with a pre-miRNA substrate | | 分子名称: | Endoribonuclease Dicer, RISC-loading complex subunit TARBP2, RNA (73-mer) | | 著者 | Liu, Z, Wang, J, Cheng, H, Ke, X, Sun, L, Zhang, Q.C, Wang, H.-W. | | 登録日 | 2018-02-07 | | 公開日 | 2018-05-09 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | | 主引用文献 | Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate.
Cell, 173, 2018
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3C66
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