PDB: 243531 件ウェブページステータス検索Chemie searchBIRD

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3LHJ	Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Pyrazolopyridinone Inhibitor. 分子名称: Mitogen-activated protein kinase 14, N-cyclopropyl-3-[1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-5-yl]-4-methylbenzamide 著者 Mohr, C, Jordan, S. 登録日 2010-01-22 公開日 2010-04-14 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.31 Å) 主引用文献 Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinase. J.Med.Chem., 53, 2010
1ZMF	C domain of human cyclophilin-33(hcyp33) 分子名称: Peptidyl-prolyl cis-trans isomerase E 著者 Wang, T, Yun, C.-H, Gu, S.-Y, Chang, W.-R, Liang, D.-C. 登録日 2005-05-10 公開日 2005-08-02 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 1.88A crystal structure of the C domain of hCyP33: A novel domain of peptidyl-prolyl cis-trans isomerase Biochem.Biophys.Res.Commun., 333, 2005
3BUF	BACE-1 complexed with compound 2 分子名称: 4-[(2R)-2-aminopropyl]phenol, Beta-secretase 1 著者 Kuglstatter, A, Hennig, M. 登録日 2008-01-02 公開日 2008-03-11 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Tyramine fragment binding to BACE-1 Bioorg.Med.Chem.Lett., 18, 2008
2P4I	Evolution of a highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor 分子名称: 4-METHYL-3-({3-[2-(METHYLAMINO)PYRIMIDIN-4-YL]PYRIDIN-2-YL}OXY)-N-[2-MORPHOLIN-4-YL-5-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE, Angiopoietin-1 receptor 著者 Bellon, S.F. 登録日 2007-03-12 公開日 2007-03-20 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor. J.Med.Chem., 50, 2007
3BUG	BACE-1 complexed with compound 3 分子名称: 4-(2-aminoethyl)-2-ethylphenol, BETA-SECRETASE 1 著者 Kuglstatter, A, Hennig, M. 登録日 2008-01-02 公開日 2008-03-11 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Tyramine fragment binding to BACE-1 Bioorg.Med.Chem.Lett., 18, 2008
3OJM	Crystal Structure of FGF1 complexed with the ectodomain of FGFR2b harboring P253R Apert mutation 分子名称: Fibroblast growth factor receptor 2, Heparin-binding growth factor 1, SULFATE ION 著者 Beenken, A, Mohammadi, M. 登録日 2010-08-23 公開日 2011-08-31 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Plasticity in Interactions of Fibroblast Growth Factor 1 (FGF1) N Terminus with FGF Receptors Underlies Promiscuity of FGF1. J.Biol.Chem., 287, 2012
2QJH	M. jannaschii ADH synthase covalently bound to dihydroxyacetone phosphate 分子名称: 1,3-DIHYDROXYACETONEPHOSPHATE, Putative aldolase MJ0400 著者 Ealick, S.E, Morar, M. 登録日 2007-07-07 公開日 2007-10-30 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids. Biochemistry, 46, 2007
2GAG	Heteroteterameric sarcosine: structure of a diflavin metaloenzyme at 1.85 a resolution 分子名称: 2-FUROIC ACID, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Chen, Z.W, Hassan-Abdulah, A, Zhao, G, Jorns, M.S, Mathews, F.S. 登録日 2006-03-08 公開日 2006-08-08 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Heterotetrameric sarcosine oxidase: structure of a diflavin metalloenzyme at 1.85 a resolution. J.Mol.Biol., 360, 2006
2QVD	Identification of a potent anti-inflammatory agent from the natural extract of plant Cardiospermun helicacabum: Crystal structure of the complex of phospholipase A2 with Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy at 1.93 A resolution 分子名称: BERBERINE, Phospholipase A2 VRV-PL-VIIIa 著者 Kumar, S, Chandra, D.N, Singh, N, Jithesh, O, Sharma, S, Haridas, M, Singh, T.P. 登録日 2007-08-08 公開日 2007-08-21 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Identification of a novel and potent inhibitor of phospholipase A(2) in a medicinal plant: crystal structure at 1.93A and Surface Plasmon Resonance analysis of phospholipase A(2) complexed with berberine Biochim.Biophys.Acta, 1814, 2011
7WR8	Local CryoEM structure of the SARS-CoV-2 S6P(B.1.1.529) in complex with BD55-3152 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, BD55-3152H, BD55-3152L, ... 著者 Du, S, Xiao, J.Y. 登録日 2022-01-26 公開日 2022-06-22 最終更新日 2025-06-18 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection. Nature, 608, 2022
1PI7	Structure of the channel-forming trans-membrane domain of Virus protein "u" (Vpu) from HIV-1 分子名称: VPU protein 著者 Park, S.H, Mrse, A.A, Nevzorov, A.A, Mesleh, M.F, Oblatt-Montal, M, Montal, M, Opella, S.J. 登録日 2003-05-29 公開日 2003-11-11 最終更新日 2024-05-22 実験手法 SOLID-STATE NMR 主引用文献 Three-dimensional structure of the channel-forming trans-membrane domain of virus protein "u" (Vpu) from HIV-1 J.Mol.Biol., 333, 2003
1BHP	STRUCTURE OF BETA-PUROTHIONIN AT ROOM TEMPERATURE AND 1.7 ANGSTROMS RESOLUTION 分子名称: ACETATE ION, BETA-PUROTHIONIN, GLYCEROL, ... 著者 Teeter, M.M, Stec, B, Rao, U. 登録日 1995-03-15 公開日 1996-03-15 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Refinement of purothionins reveals solute particles important for lattice formation and toxicity. Part 2: structure of beta-purothionin at 1.7 A resolution. Acta Crystallogr.,Sect.D, 51, 1995
1AXB	TEM-1 BETA-LACTAMASE FROM ESCHERICHIA COLI INHIBITED WITH AN ACYLATION TRANSITION STATE ANALOG 分子名称: TEM-1 BETA LACTAMASE, [[N-(BENZYLOXYCARBONYL)AMINO]METHYL]PHOSPHATE 著者 Maveyraud, L, Pratt, R.F, Samama, J.P. 登録日 1997-10-14 公開日 1998-10-28 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of an acylation transition-state analog of the TEM-1 beta-lactamase. Mechanistic implications for class A beta-lactamases. Biochemistry, 37, 1998
3U2T	Crystal Structure of Human Glycogenin-1 (GYG1) complexed with manganese 分子名称: 1,2-ETHANEDIOL, Glycogenin-1, MANGANESE (II) ION 著者 Chaikuad, A, Froese, D.S, Krysztofinska, E, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Oppermann, U, Yue, W.W, Structural Genomics Consortium (SGC) 登録日 2011-10-04 公開日 2011-11-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis. Proc.Natl.Acad.Sci.USA, 108, 2011
3TV1	Crystal structure of RtcA.AMP product complex 分子名称: 1,2-ETHANEDIOL, ADENOSINE MONOPHOSPHATE, CHLORIDE ION, ... 著者 Chakravarty, A.K, Smith, P, Shuman, S. 登録日 2011-09-19 公開日 2011-12-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structures of RNA 3'-phosphate cyclase bound to ATP reveal the mechanism of nucleotidyl transfer and metal-assisted catalysis. Proc.Natl.Acad.Sci.USA, 108, 2011
3CYY	The crystal structure of ZO-1 PDZ2 in complex with the Cx43 peptide 分子名称: Tight junction protein ZO-1, peptide from Gap junction alpha-1 protein 著者 Pan, L, Zhang, M. 登録日 2008-04-27 公開日 2008-09-23 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Domain-swapped dimerization of ZO-1 PDZ2 generates specific and regulatory connexin43-binding sites Embo J., 27, 2008
3U1N	Structure of the catalytic core of human SAMHD1 分子名称: PHOSPHATE ION, SAM domain and HD domain-containing protein 1, ZINC ION 著者 Goldstone, D.C, Ennis-Adeniran, V, Walker, P.A, Haire, L.F, Webb, M, Taylor, I.A. 登録日 2011-09-30 公開日 2011-11-16 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase Nature, 480, 2011
9CU5	LJF-085 Fab in complex with HIV Env JRFL NFL TD CC3+ trimer and 35O22 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 heavy chain Fv, ... 著者 Ozorowski, G, Ward, A.B. 登録日 2024-07-25 公開日 2025-05-21 最終更新日 2025-06-25 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Vaccination of nonhuman primates elicits a broadly neutralizing antibody lineage targeting a quaternary epitope on the HIV-1 Env trimer. Immunity, 58, 2025
3CVP	Structure of Peroxisomal Targeting Signal 1 (PTS1) binding domain of Trypanosoma brucei Peroxin 5 (TbPEX5)complexed to PTS1 peptide (10-SKL) 分子名称: 10-SKL PTS1 peptide Ac-GTLSNRASKL, Peroxisome targeting signal 1 receptor PEX5 著者 Sampathkumar, P, Roach, C, Michels, P.A.M, Hol, W.G.J. 登録日 2008-04-18 公開日 2008-06-24 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5. J.Mol.Biol., 381, 2008
5W5G	Structure of Human Sts-1 histidine phosphatase domain 分子名称: Ubiquitin-associated and SH3 domain-containing protein B 著者 Zhou, W, Yin, Y, Weinheimer, A.W, Kaur, N, Carpino, N, French, J.B. 登録日 2017-06-15 公開日 2017-08-16 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.48 Å) 主引用文献 Structural and Functional Characterization of the Histidine Phosphatase Domains of Human Sts-1 and Sts-2. Biochemistry, 56, 2017
3KSP	Crystal structure of a putative ca/calmodulin-dependent kinase ii association domain (exig_1688) from exiguobacterium sibiricum 255-15 at 2.59 A resolution 分子名称: 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Calcium/calmodulin-dependent kinase II association domain 著者 Joint Center for Structural Genomics (JCSG) 登録日 2009-11-23 公開日 2009-12-29 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.59 Å) 主引用文献 Crystal structure of Calcium/calmodulin-dependent kinase II association domain (YP_001814158.1) from EXIGUOBACTERIUM SP. 255-15 at 2.59 A resolution To be published
3D5U	Crystal structure of a wildtype Polo-like kinase 1 (Plk1) catalytic domain. 分子名称: Polo-like kinase 1 著者 Elling, R.A, Fucini, R.V, Romanowski, M.J. 登録日 2008-05-17 公開日 2008-08-26 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structures of the wild-type and activated catalytic domains of Brachydanio rerio Polo-like kinase 1 (Plk1): changes in the active-site conformation and interactions with ligands. Acta Crystallogr.,Sect.D, 64, 2008
2MG2	NMR assignment and structure of a peptide derived from the membrane proximal external region of HIV-1 gp41 in the presence of hexafluoroisopropanol 分子名称: Transmembrane protein gp41 著者 Serrano, S, Apellaniz, B, Huarte, N.L, Nieva, J.L, Jimenez, M.A. 登録日 2013-10-24 公開日 2015-03-25 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 The Atomic Structure of the HIV-1 gp41 Transmembrane Domain and Its Connection to the Immunogenic Membrane-proximal External Region. J.Biol.Chem., 290, 2015
3D7B	The Ribonuclease A- 5'-Deoxy-5'-N-pyrrolidinouridine complex 分子名称: 1-(5-deoxy-5-pyrrolidin-1-yl-alpha-L-arabinofuranosyl)pyrimidine-2,4(1H,3H)-dione, CITRATE ANION, Ribonuclease pancreatic 著者 Leonidas, D.D, Zographos, S.E, Oikonomakos, N.G. 登録日 2008-05-21 公開日 2009-02-10 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Morpholino, piperidino, and pyrrolidino derivatives of pyrimidine nucleosides as inhibitors of ribonuclease A: synthesis, biochemical, and crystallographic evaluation. J.Med.Chem., 52, 2009
4BE0	PFV intasome with inhibitor XZ-115 分子名称: 17 NUCLEOTIDE PREPROCESSED PFV DONOR DNA (TRANSFERRED STRAND), 19 NUCLEOTIDE PREPROCESSED PFV DONOR DNA (NON-TRANSFERRED STRAND), 2-(3-chloro-2-fluorobenzyl)-4,5-dihydroxy-1H-isoindole-1,3(2H)-dione, ... 著者 Hare, S, Cherepanov, P. 登録日 2012-10-08 公開日 2012-10-31 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 Activities, Crystal Structures and Molecular Dynamics of Dihydro-1H-Isoindole Derivatives, Inhibitors of HIV-1 Integrase. Acs Chem.Biol., 8, 2013

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