3D7B

The Ribonuclease A- 5'-Deoxy-5'-N-pyrrolidinouridine complex

Summary for 3D7B

Related3D6O 3D6P 3D6Q
DescriptorRibonuclease pancreatic, CITRATE ANION, 1-(5-deoxy-5-pyrrolidin-1-yl-alpha-L-arabinofuranosyl)pyrimidine-2,4(1H,3H)-dione, ... (4 entities in total)
Functional Keywordshydrolase, ribonuclease a, ligand, endonuclease, glycation, glycoprotein, nuclease, secreted
Biological sourceBos taurus (bovine)
Cellular locationSecreted P61823
Total number of polymer chains2
Total molecular weight28092.16
Authors
Leonidas, D.D.,Zographos, S.E.,Oikonomakos, N.G. (deposition date: 2008-05-21, release date: 2009-02-10, Last modification date: 2011-07-13)
Primary citation
Samanta, A.,Leonidas, D.D.,Dasgupta, S.,Pathak, T.,Zographos, S.E.,Oikonomakos, N.G.
Morpholino, piperidino, and pyrrolidino derivatives of pyrimidine nucleosides as inhibitors of ribonuclease A: synthesis, biochemical, and crystallographic evaluation.
J.Med.Chem., 52:932-942, 2009
PubMed: 19173562 (PDB entries with the same primary citation)
DOI: 10.1021/jm800724t
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.6 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.210401.4%8.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution