7PIV
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![BU of 7piv by Molmil](/molmil-images/mine/7piv) | Active Melanocortin-4 receptor (MC4R)- Gs protein complex bound to agonist NDP-alpha-MSH at 2.86 A resolution. | 分子名称: | CALCIUM ION, Camelid antibody VHH fragment - nanobody 35, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Heyder, N.A, Schmidt, A, Kleinau, G, Hilal, T, Scheerer, P. | 登録日 | 2021-08-23 | 公開日 | 2021-11-17 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-alpha-MSH and setmelanotide. Cell Res., 31, 2021
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7Q2J
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![BU of 7q2j by Molmil](/molmil-images/mine/7q2j) | Quaternary Complex of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC Homer | 分子名称: | Elongin-B, Elongin-C, N-[5-[4-[[5-[[(2S)-3,3-dimethyl-1-[(2S,4R)-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]-4-oxidanyl-pyrrolidin-1-yl]-1-oxidanylidene-butan-2-yl]amino]-5-oxidanylidene-pentyl]carbamoyl]phenyl]-2-(4-methylpiperazin-1-yl)phenyl]-6-oxidanylidene-4-(trifluoromethyl)-1H-pyridine-3-carboxamide, ... | 著者 | Kraemer, A, Doelle, A, Schwalm, M.P, Adhikari, B, Wolf, E, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2021-10-25 | 公開日 | 2021-11-24 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization. Cell Chem Biol, 30, 2023
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7RRO
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![BU of 7rro by Molmil](/molmil-images/mine/7rro) | Structure of the 48-nm repeat doublet microtubule from bovine tracheal cilia | 分子名称: | Armadillo repeat containing 4, Chromosome 3 C1orf194 homolog, Cilia and flagella associated protein 161, ... | 著者 | Gui, M, Anderson, J.R, Botsch, J.J, Meleppattu, S, Singh, S.K, Zhang, Q, Brown, A. | 登録日 | 2021-08-10 | 公開日 | 2021-10-27 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | De novo identification of mammalian ciliary motility proteins using cryo-EM. Cell, 184, 2021
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7RMI
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![BU of 7rmi by Molmil](/molmil-images/mine/7rmi) | SP6-11 biased agonist bound to active human neurokinin 1 receptor in complex with miniGs/q70 | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Harris, J.A, Faust, B, Gondin, A.B, Daemgen, M.A, Suomivuori, C.M, Veldhuis, N.A, Cheng, Y, Dror, R.O, Thal, D, Manglik, A. | 登録日 | 2021-07-27 | 公開日 | 2021-11-03 | 最終更新日 | 2022-01-05 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Selective G protein signaling driven by substance P-neurokinin receptor dynamics. Nat.Chem.Biol., 18, 2022
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7RMG
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![BU of 7rmg by Molmil](/molmil-images/mine/7rmg) | Substance P bound to active human neurokinin 1 receptor in complex with miniGs/q70 | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Harris, J.A, Faust, B, Gondin, A.B, Daemgen, M.A, Suomivuori, C.M, Veldhuis, N.A, Cheng, Y, Dror, R.O, Thal, D, Manglik, A. | 登録日 | 2021-07-27 | 公開日 | 2021-11-03 | 最終更新日 | 2022-01-05 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Selective G protein signaling driven by substance P-neurokinin receptor dynamics. Nat.Chem.Biol., 18, 2022
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7RMH
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![BU of 7rmh by Molmil](/molmil-images/mine/7rmh) | Substance P bound to active human neurokinin 1 receptor in complex with miniGs399 | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Harris, J.A, Faust, B, Gondin, A.B, Daemgen, M.A, Suomivuori, C.M, Veldhuis, N.A, Cheng, Y, Dror, R.O, Thal, D, Manglik, A. | 登録日 | 2021-07-27 | 公開日 | 2021-11-03 | 最終更新日 | 2022-01-05 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Selective G protein signaling driven by substance P-neurokinin receptor dynamics. Nat.Chem.Biol., 18, 2022
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7R5K
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![BU of 7r5k by Molmil](/molmil-images/mine/7r5k) | Human nuclear pore complex (constricted) | 分子名称: | Aladin, E3 SUMO-protein ligase RanBP2, Nuclear pore complex protein Nup107, ... | 著者 | Mosalaganti, S, Obarska-Kosinska, A, Siggel, M, Taniguchi, R, Turonova, B, Zimmerli, C.E, Buczak, K, Schmidt, F.H, Margiotta, E, Mackmull, M.T, Hagen, W.J.H, Hummer, G, Kosinski, J, Beck, M. | 登録日 | 2022-02-10 | 公開日 | 2022-06-22 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (12 Å) | 主引用文献 | AI-based structure prediction empowers integrative structural analysis of human nuclear pores. Science, 376, 2022
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7RAN
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![BU of 7ran by Molmil](/molmil-images/mine/7ran) | 5-HT2AR bound to a novel agonist in complex with a mini-Gq protein and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM) | 分子名称: | (3R)-3-methyl-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,2,3,6-tetrahydropyridin-1-ium, 5-hydroxytryptamine receptor 2A, G protein subunit q (Gi2-mini-Gq chimera), ... | 著者 | Barros-Alvarez, X, Kim, K, Panova, O, Roth, B.L, Skiniotis, G. | 登録日 | 2021-07-02 | 公開日 | 2022-07-06 | 最終更新日 | 2022-11-02 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | Bespoke library docking for 5-HT 2A receptor agonists with antidepressant activity. Nature, 610, 2022
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7PWD
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![BU of 7pwd by Molmil](/molmil-images/mine/7pwd) | Structure of an inhibited GRK2-G-beta and G-gamma complex | 分子名称: | 4-chloranyl-N-[2-(4-chlorophenyl)ethyl]thieno[2,3-c]pyridine-2-carboxamide, Beta-adrenergic receptor kinase 1, CHLORIDE ION, ... | 著者 | Faucher, N, Tauchert, M.J, Konz Makino, D.L, Vuillard, L.M. | 登録日 | 2021-10-06 | 公開日 | 2021-10-20 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Synthesis of thieno[2,3-c]pyridine derived GRK2 inhibitors Monatsh Chem, 2022
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7R5J
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![BU of 7r5j by Molmil](/molmil-images/mine/7r5j) | Human nuclear pore complex (dilated) | 分子名称: | Aladin, E3 SUMO-protein ligase RanBP2, Nuclear pore complex protein Nup107, ... | 著者 | Mosalaganti, S, Obarska-Kosinska, A, Siggel, M, Taniguchi, R, Turonova, B, Zimmerli, C.E, Buczak, K, Schmidt, F.H, Margiotta, E, Mackmull, M.T, Hagen, W.J.H, Hummer, G, Kosinski, J, Beck, M. | 登録日 | 2022-02-10 | 公開日 | 2022-09-21 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (50 Å) | 主引用文献 | AI-based structure prediction empowers integrative structural analysis of human nuclear pores Science, 376, 2022
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7R72
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![BU of 7r72 by Molmil](/molmil-images/mine/7r72) | State E1 nucleolar 60S ribosome biogenesis intermediate - Spb4 local model | 分子名称: | 25S rRNA, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, 5.8S rRNA, ... | 著者 | Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P. | 登録日 | 2021-06-24 | 公開日 | 2022-11-09 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | Sequence-specific remodeling of a topologically complex RNP substrate by Spb4. Nat.Struct.Mol.Biol., 29, 2022
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7R7A
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![BU of 7r7a by Molmil](/molmil-images/mine/7r7a) | State E1 nucleolar 60S ribosome biogenesis intermediate - Composite model | 分子名称: | 25S rRNA, 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, ... | 著者 | Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P. | 登録日 | 2021-06-24 | 公開日 | 2022-11-09 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | Sequence-specific remodeling of a topologically complex RNP substrate by Spb4. Nat.Struct.Mol.Biol., 29, 2022
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7R6Q
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![BU of 7r6q by Molmil](/molmil-images/mine/7r6q) | State E2 nucleolar 60S ribosome biogenesis intermediate - Foot region model | 分子名称: | 25S rRNA, 5.8S rRNA, 60S ribosomal protein L13-A, ... | 著者 | Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P. | 登録日 | 2021-06-23 | 公開日 | 2022-11-09 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Sequence-specific remodeling of a topologically complex RNP substrate by Spb4. Nat.Struct.Mol.Biol., 29, 2022
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7R4X
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![BU of 7r4x by Molmil](/molmil-images/mine/7r4x) | Cryo-EM reconstruction of the human 40S ribosomal subunit - Full map | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | 著者 | Pellegrino, S, Dent, K.C, Spikes, T, Warren, A.J. | 登録日 | 2022-02-09 | 公開日 | 2023-02-22 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.15 Å) | 主引用文献 | Cryo-EM reconstruction of the human 40S ribosomal subunit at 2.15 angstrom resolution. Nucleic Acids Res., 51, 2023
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7ZW0
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![BU of 7zw0 by Molmil](/molmil-images/mine/7zw0) | FAP-80S Complex - Rotated state | 分子名称: | 18S ribosomal RNA (RDN18-1), 25S ribosomal RNA (RDN25-1), 40S ribosomal protein S0-A, ... | 著者 | Ikeuchi, K, Buschauer, R, Berninghausen, O, Becker, T, Beckmann, R. | 登録日 | 2022-05-17 | 公開日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Sensing of individual stalled 80S ribosomes by Fap1 for nonfunctional rRNA turnover. Mol.Cell, 82, 2022
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7ZJW
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![BU of 7zjw by Molmil](/molmil-images/mine/7zjw) | Rabbit 80S ribosome as it decodes the Sec-UGA codon | 分子名称: | 18S rRNA, 28S rRNA, 40S Ribosomal protein eS19, ... | 著者 | Hilal, T, Simonovic, M, Spahn, C.M.T. | 登録日 | 2022-04-12 | 公開日 | 2022-10-19 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon. Science, 376, 2022
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8A9J
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![BU of 8a9j by Molmil](/molmil-images/mine/8a9j) | |
7ZNK
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![BU of 7znk by Molmil](/molmil-images/mine/7znk) | Structure of an endogenous human TREX complex bound to mRNA | 分子名称: | RNA, Spliceosome RNA helicase DDX39B, THO complex subunit 1, ... | 著者 | Pacheco-Fiallos, F.B, Vorlaender, M.K, Plaschka, C. | 登録日 | 2022-04-21 | 公開日 | 2023-05-03 | 最終更新日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | mRNA recognition and packaging by the human transcription-export complex. Nature, 616, 2023
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7ZNL
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![BU of 7znl by Molmil](/molmil-images/mine/7znl) | Structure of the human TREX core THO-UAP56 complex | 分子名称: | Spliceosome RNA helicase DDX39B, THO complex subunit 1, THO complex subunit 2, ... | 著者 | Pacheco-Fiallos, F.B, Vorlaender, M.K, Plaschka, C. | 登録日 | 2022-04-21 | 公開日 | 2023-05-17 | 最終更新日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | mRNA recognition and packaging by the human transcription-export complex. Nature, 616, 2023
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8A98
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![BU of 8a98 by Molmil](/molmil-images/mine/8a98) | CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : snoRNA MUTANT | 分子名称: | 40S ribosomal protein S12, 40S ribosomal protein S14, 40S ribosomal protein S19-like protein, ... | 著者 | Rajan, K.S, Yonath, A, Bashan, A. | 登録日 | 2022-06-28 | 公開日 | 2023-10-11 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.46 Å) | 主引用文献 | Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification. Cell Rep, 43, 2024
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8A3W
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![BU of 8a3w by Molmil](/molmil-images/mine/8a3w) | |
8AJM
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![BU of 8ajm by Molmil](/molmil-images/mine/8ajm) | Structure of human DDB1-DCAF12 in complex with the C-terminus of CCT5 | 分子名称: | DDB1- and CUL4-associated factor 12, DNA damage-binding protein 1, T-complex protein 1 subunit epsilon | 著者 | Pla-Prats, C, Cavadini, S, Kempf, G, Thoma, N.H. | 登録日 | 2022-07-28 | 公開日 | 2022-11-09 | 最終更新日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | 主引用文献 | Recognition of the CCT5 di-Glu degron by CRL4 DCAF12 is dependent on TRiC assembly. Embo J., 42, 2023
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8AJO
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![BU of 8ajo by Molmil](/molmil-images/mine/8ajo) | Negative-stain electron microscopy structure of DDB1-DCAF12-CCT5 | 分子名称: | DDB1- and CUL4-associated factor 12, DNA damage-binding protein 1, T-complex protein 1 subunit epsilon | 著者 | Pla-Prats, C, Cavadini, S, Kempf, G, Thoma, N.H. | 登録日 | 2022-07-28 | 公開日 | 2022-11-09 | 最終更新日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (30.6 Å) | 主引用文献 | Recognition of the CCT5 di-Glu degron by CRL4 DCAF12 is dependent on TRiC assembly. Embo J., 42, 2023
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8AUV
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![BU of 8auv by Molmil](/molmil-images/mine/8auv) | Cryo-EM structure of the plant 40S subunit | 分子名称: | 18S rRNA, MAGNESIUM ION, POTASSIUM ION, ... | 著者 | Smirnova, J, Loerke, J, Kleinau, G, Schmidt, A, Buerger, J, Meyer, E.H, Mielke, T, Scheerer, P, Bock, R, Spahn, C.M.T, Zoschke, R. | 登録日 | 2022-08-25 | 公開日 | 2023-06-07 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.38 Å) | 主引用文献 | Structure of the actively translating plant 80S ribosome at 2.2 angstrom resolution. Nat.Plants, 9, 2023
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8B2L
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![BU of 8b2l by Molmil](/molmil-images/mine/8b2l) | Cryo-EM structure of the plant 80S ribosome | 分子名称: | 18S rRNA, 25S rRNA, 30S ribosomal protein S15, ... | 著者 | Smirnova, J, Loerke, J, Kleinau, G, Schmidt, A, Buerger, J, Meyer, E.H, Mielke, T, Scheerer, P, Bock, R, Spahn, C.M.T, Zoschke, R. | 登録日 | 2022-09-14 | 公開日 | 2023-08-23 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | Structure of the actively translating plant 80S ribosome at 2.2 angstrom resolution. Nat.Plants, 9, 2023
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