PDB: 137 件ウェブページステータス検索Chemie searchBIRD

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6YII	Crystal structure of a Class III adenylyl cyclase-like ATP-binding protein from Pseudomonas aeruginosa 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, MAGNESIUM ION, ... 著者 Moniot, S, Steegborn, C. 登録日 2020-04-01 公開日 2020-06-17 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.44 Å) 主引用文献 Crystal structure of a class III adenylyl cyclase-like ATP-binding protein from Pseudomonas aeruginosa. J.Struct.Biol., 211, 2020
7D9R	Structure of huamn soluble guanylate cyclase in the riociguat and NO-bound state 分子名称: Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ... 著者 Chen, L, Liu, R, Kang, Y. 登録日 2020-10-14 公開日 2021-08-11 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Activation mechanism of human soluble guanylate cyclase by stimulators and activators. Nat Commun, 12, 2021
7D9S	Structure of huamn soluble guanylate cyclase in the YC1 and NO-bound state 分子名称: Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ... 著者 Chen, L, Liu, R, Kang, Y. 登録日 2020-10-14 公開日 2021-08-11 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Activation mechanism of human soluble guanylate cyclase by stimulators and activators. Nat Commun, 12, 2021
7D9T	Structure of human soluble guanylate cyclase in the cinciguat-bound inactive state 分子名称: 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid, Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1 著者 Chen, L, Liu, R, Kang, Y. 登録日 2020-10-14 公開日 2021-08-11 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Activation mechanism of human soluble guanylate cyclase by stimulators and activators. Nat Commun, 12, 2021
7D9U	Structure of human soluble guanylate cyclase in the cinciguat-bound activated state 分子名称: 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid, Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, ... 著者 Chen, L, Liu, R, Kang, Y. 登録日 2020-10-14 公開日 2021-08-11 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Activation mechanism of human soluble guanylate cyclase by stimulators and activators. Nat Commun, 12, 2021
7OVD	Human soluble adenylyl cyclase in complex with the inhibitor TDI10229 分子名称: 1,2-ETHANEDIOL, 4-chloranyl-6-[1,5-dimethyl-4-(phenylmethyl)pyrazol-3-yl]pyrimidin-2-amine, ACETATE ION, ... 著者 Steegborn, C, Quast, J. 登録日 2021-06-14 公開日 2021-10-06 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10). Acs Med.Chem.Lett., 12, 2021
7PD4	structure of Adenylyl cyclase 9 in complex with MANT-GTP 分子名称: Adenylate cyclase 9 著者 Qi, C, Korkhov, V.M. 登録日 2021-08-04 公開日 2022-01-19 最終更新日 2022-03-09 実験手法 ELECTRON MICROSCOPY (4.9 Å) 主引用文献 Structural basis of adenylyl cyclase 9 activation. Nat Commun, 13, 2022
7PD8	Structure of Adenylyl cyclase 9 in complex with DARPin C4 and MANT-GTP 分子名称: Adenylate cyclase 9, DARPin C4 著者 Qi, C, Korkhov, V.M. 登録日 2021-08-04 公開日 2022-01-19 最終更新日 2022-03-09 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Structural basis of adenylyl cyclase 9 activation. Nat Commun, 13, 2022
7PDD	Focus refinement of soluble domain of Adenylyl cyclase 9 in complex with DARPin C4 and MANT-GTP 分子名称: Adenylate cyclase 9, DARPin C4 著者 Qi, C, Korkhov, V.M. 登録日 2021-08-05 公開日 2022-01-19 最終更新日 2022-03-09 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Structural basis of adenylyl cyclase 9 activation. Nat Commun, 13, 2022
7PDE	Structure of Adenylyl cyclase 9 in complex with Gs protein alpha subunit and MANT-GTP 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase 9, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Qi, C, Korkhov, V.M. 登録日 2021-08-05 公開日 2022-01-19 最終更新日 2022-03-09 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 Structural basis of adenylyl cyclase 9 activation. Nat Commun, 13, 2022
7PDF	focus refinement of soluble domain of adenylyl cyclase 9 in complex with Gs protein alpha subunit and MANT-GTP 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase 9, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Qi, C, Korkhov, V.M. 登録日 2021-08-05 公開日 2022-01-26 最終更新日 2022-03-09 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structural basis of adenylyl cyclase 9 activation. Nat Commun, 13, 2022
7PDG	structure of adenylyl cyclase 9 in complex with DARPin C4 and ATP-aS 分子名称: Adenylate cyclase 9, DARPin C4 著者 Qi, C, Korkhov, V.M. 登録日 2021-08-05 公開日 2022-01-19 最終更新日 2022-03-09 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Structural basis of adenylyl cyclase 9 activation. Nat Commun, 13, 2022
7PDH	structure of adenylyl cyclase 9 in complex with DARPin C4 and ATP-aS 分子名称: Adenylate cyclase 9, DARPin C4 著者 Qi, C, Korkhov, V.M. 登録日 2021-08-05 公開日 2022-01-19 最終更新日 2022-03-09 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structural basis of adenylyl cyclase 9 activation. Nat Commun, 13, 2022
7R65	Crystal structure of a bacterial cyclic UMP synthase from Burkholderia cepacia LK29 分子名称: Adenylate/guanylate cyclase 著者 Morehouse, B.R, Kranzusch, P.J. 登録日 2021-06-22 公開日 2021-10-13 最終更新日 2021-11-24 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Cyclic CMP and cyclic UMP mediate bacterial immunity against phages. Cell, 184, 2021
7YZ9	Structure of catalytic domain of Rv1625c bound to nanobody NB4 分子名称: 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE, Adenylate cyclase, GLYCEROL, ... 著者 Khanppnavar, B, Mehta, V.J, Iype, T, Korkhov, V.M. 登録日 2022-02-19 公開日 2022-08-31 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases. Elife, 11, 2022
7YZI	Structure of Mycobacterium tuberculosis adenylyl cyclase Rv1625c / Cya 分子名称: 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE, Adenylate cyclase, MANGANESE (II) ION, ... 著者 Mehta, V, Khanppnavar, B, Korkhov, V.M. 登録日 2022-02-20 公開日 2022-10-05 実験手法 ELECTRON MICROSCOPY (3.83 Å) 主引用文献 Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases. Elife, 11, 2022
7YZK	Structure of Mycobacterium tuberculosis adenylyl cyclase Rv1625c / Cya 分子名称: 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE, Adenylate cyclase, MANGANESE (II) ION, ... 著者 Mehta, V, Khanppnavar, B, Korkhov, V.M. 登録日 2022-02-20 公開日 2022-08-31 実験手法 ELECTRON MICROSCOPY (3.57 Å) 主引用文献 Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases. Elife, 11, 2022
8B75	CRYSTAL STRUCTURE OF HUMAN SOLUBLE ADENYLYL CYCLASE IN COMPLEX WITH THE INHIBITOR TDI-011861 分子名称: Adenylate cyclase type 10, [(3~{R})-4-[2-[2-[[3-(2-azanyl-6-chloranyl-pyrimidin-4-yl)-1-[bis(fluoranyl)methyl]pyrazol-4-yl]methyl]phenoxy]ethyl]morpholin-3-yl]methanol 著者 Steegborn, C, Kehr, M. 登録日 2022-09-28 公開日 2023-03-29 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates. J.Med.Chem., 65, 2022
8BUZ	Structure of Adenylyl cyclase 8 bound to stimulatory G-protein, Ca2+/Calmodulin, Forskolin and MANT-GTP 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase type 8, FORSKOLIN, ... 著者 Khanppnavar, B, Korkhov, V.M, Mehta, V. 登録日 2022-12-01 公開日 2023-12-13 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics. Embo Rep., 25, 2024
8BV5	Focus refinement of soluble domain of Adenylyl cyclase 8 bound to stimulatory G protein, Forskolin, ATPalphaS, and Ca2+/Calmodulin in lipid nanodisc conditions 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase type 8, FORSKOLIN, ... 著者 Khanppnavar, B, Korkhov, V.M. 登録日 2023-01-04 公開日 2024-01-17 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.54 Å) 主引用文献 Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics. Embo Rep., 25, 2024
8CNH	Crystal structure of human soluble adenylyl cyclase (sAC) in complex with inhibitor TDI-10512 分子名称: 1,2-ETHANEDIOL, ACETATE ION, Adenylate cyclase type 10, ... 著者 Steegborn, C. 登録日 2023-02-23 公開日 2023-04-26 最終更新日 2023-05-17 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation. J.Chem.Inf.Model., 63, 2023
8CO7	Crystal structure of human soluble adenylyl cyclase (sAC) in complex with inhibitor TDI-09066 分子名称: 1,2-ETHANEDIOL, 4-chloranyl-6-[1-methyl-4-(thiophen-2-ylmethyl)pyrazol-3-yl]pyrimidin-2-amine, ACETATE ION, ... 著者 Steegborn, C. 登録日 2023-02-27 公開日 2024-01-03 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation. J.Chem.Inf.Model., 63, 2023
8COJ	Crystal structure of human soluble adenylyl cyclase catalytic domain in complex with the inhibitor TDI-10228 分子名称: 1,2-ETHANEDIOL, 4-chloranyl-6-[4-[(3-fluorophenyl)methyl]-1-methyl-pyrazol-3-yl]pyrimidin-2-amine, ACETATE ION, ... 著者 Steegborn, C, Fushimi, M. 登録日 2023-02-28 公開日 2023-04-26 最終更新日 2023-05-17 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation. J.Chem.Inf.Model., 63, 2023
8COT	Complex of human soluble adenylyl cyclase 10 catalytic core with inhibitor TDI-10962 分子名称: 1,2-ETHANEDIOL, 2-(dimethylamino)ethyl 5-(2-azanyl-6-chloranyl-pyrimidin-4-yl)-2-methyl-4-(phenylmethyl)pyrazole-3-carboxylate, ACETATE ION, ... 著者 Steegborn, C, Fushimi, M. 登録日 2023-02-28 公開日 2023-04-26 最終更新日 2023-05-17 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation. J.Chem.Inf.Model., 63, 2023
8FX4	GC-C-Hsp90-Cdc37 regulatory complex 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Guanylyl cyclase C, Heat shock protein HSP 90-beta, ... 著者 Caveney, N.A, Garcia, K.C. 登録日 2023-01-23 公開日 2023-07-12 最終更新日 2023-08-23 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism. Elife, 12, 2023

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