2FTM
 
 | | Crystal structure of trypsin complexed with the BPTI variant (Tyr35->Gly) | | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, Cationic trypsin, ... | | 著者 | Hanson, W.M, Horvath, M.P, Goldenberg, D.P. | | 登録日 | 2006-01-24 | | 公開日 | 2006-02-14 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Rigidification of a Flexible Protease Inhibitor Variant upon Binding to Trypsin.
J.Mol.Biol., 366, 2007
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5C67
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4Y0Z
 | | Trypsin in complex with with BPTI mutant AMINOBUTYRIC ACID | | 分子名称: | CALCIUM ION, Cationic trypsin, GLYCEROL, ... | | 著者 | Loll, B, Ye, S, Berger, A.A, Muelow, U, Alings, C, Wahl, M.C, Koksch, B. | | 登録日 | 2015-02-06 | | 公開日 | 2015-06-24 | | 最終更新日 | 2018-04-18 | | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | | 主引用文献 | Fluorine teams up with water to restore inhibitor activity to mutant BPTI.
Chem Sci, 6, 2015
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4WWY
 | | human cationic trypsin G193R mutant in complex with bovine pancreatic trypsin inhibitor | | 分子名称: | CALCIUM ION, Pancreatic trypsin inhibitor, SULFATE ION, ... | | 著者 | Alloy, A, Kayode, O, Soares, A.S, Wang, R, Radisky, E.S. | | 登録日 | 2014-11-12 | | 公開日 | 2015-07-22 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Mesotrypsin Has Evolved Four Unique Residues to Cleave Trypsin Inhibitors as Substrates.
J.Biol.Chem., 290, 2015
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4WXV
 | | Human cationic trypsin K97D mutant in complex with bovine pancreatic trypsin inhibitor (BPTI) | | 分子名称: | CALCIUM ION, Pancreatic trypsin inhibitor, SULFATE ION, ... | | 著者 | Alloy, A, Kayode, O, Soares, A.S, Wang, R, Radisky, E.S. | | 登録日 | 2014-11-14 | | 公開日 | 2015-07-22 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Mesotrypsin Has Evolved Four Unique Residues to Cleave Trypsin Inhibitors as Substrates.
J.Biol.Chem., 290, 2015
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6GFI
 | | Structure of Human Mesotrypsin in complex with APPI variant T11V/M17R/I18F/F34V | | 分子名称: | 1,2-ETHANEDIOL, Amyloid-beta A4 protein, PRSS3 protein | | 著者 | Shahar, A, Cohen, I, Radisky, E, Papo, N, Naftaly, S. | | 登録日 | 2018-04-30 | | 公開日 | 2018-09-12 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries.
Nat Commun, 9, 2018
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5H7V
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3UOU
 | | Crystal structure of the Kunitz-type protease inhibitor ShPI-1 Lys13Leu mutant in complex with pancreatic elastase | | 分子名称: | Chymotrypsin-like elastase family member 1, GLYCEROL, Kunitz-type proteinase inhibitor SHPI-1, ... | | 著者 | Garcia-Fernandez, R, Perbandt, M, Rehders, D, Gonzalez-Gonzalez, Y, Chavez, M.A, Betzel, C, Redecke, L. | | 登録日 | 2011-11-17 | | 公開日 | 2012-11-21 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Three-dimensional Structure of a Kunitz-type Inhibitor in Complex with an Elastase-like Enzyme.
J.Biol.Chem., 290, 2015
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4NTX
 | | Structure of acid-sensing ion channel in complex with snake toxin and amiloride | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,5-DIAMINO-N-(AMINOIMINOMETHYL)-6-CHLOROPYRAZINECARBOXAMIDE, Acid-sensing ion channel 1, ... | | 著者 | Baconguis, I, Bohlen, C.J, Goehring, A, Julius, D, Gouaux, E. | | 登録日 | 2013-12-02 | | 公開日 | 2014-02-19 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | X-ray structure of Acid-sensing ion channel 1-snake toxin complex reveals open state of a na(+)-selective channel.
Cell(Cambridge,Mass.), 156, 2014
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4ISN
 | | Crystal Structure of Matriptase in complex with its inhibitor HAI-1 | | 分子名称: | GLUTATHIONE, Kunitz-type protease inhibitor 1, Suppressor of tumorigenicity 14 protein, ... | | 著者 | Huang, M.D, Zhao, B.Y, Yuan, C, Li, R. | | 登録日 | 2013-01-16 | | 公開日 | 2013-03-06 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1.
J.Biol.Chem., 288, 2013
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4ISL
 | | Crystal Structure of the inactive Matriptase in complex with its inhibitor HAI-1 | | 分子名称: | GLUTATHIONE, GLYCEROL, Kunitz-type protease inhibitor 1, ... | | 著者 | Huang, M.D, Zhao, B.Y, Yuan, C, Li, R. | | 登録日 | 2013-01-16 | | 公開日 | 2013-03-06 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1.
J.Biol.Chem., 288, 2013
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3U1J
 | | Aprotinin bound to Dengue virus protease | | 分子名称: | Pancreatic trypsin inhibitor, Serine protease NS3, Serine protease subunit NS2B | | 著者 | Noble, C.G. | | 登録日 | 2011-09-30 | | 公開日 | 2011-11-09 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Ligand-bound structures of the dengue virus protease reveal the active conformation
J.Virol., 86, 2012
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2R9P
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3TPI
 | | THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS | | 分子名称: | BOVINE PANCREATIC TRYPSIN INHIBITOR, CALCIUM ION, ISOLEUCINE, ... | | 著者 | Huber, R, Bode, W, Deisenhofer, J, Schwager, P. | | 登録日 | 1982-09-27 | | 公開日 | 1983-01-18 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The Geometry of the Reactive Site and of the Peptide Groups in Trypsin, Trypsinogen and its Complexes with Inhibitors
Acta Crystallogr.,Sect.B, 39, 1983
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2TGP
 | | THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS | | 分子名称: | CALCIUM ION, SULFATE ION, TRYPSIN INHIBITOR, ... | | 著者 | Huber, R, Bode, W, Deisenhofer, J, Schwager, P. | | 登録日 | 1982-09-27 | | 公開日 | 1983-01-18 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The Geometry of the Reactive Site and of the Peptide Groups in Trypsin, Trypsinogen and its Complexes with Inhibitors
Acta Crystallogr.,Sect.B, 39, 1983
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3UIR
 | | Crystal structure of the plasmin-textilinin-1 complex | | 分子名称: | Plasmin light chain B, SULFATE ION, Textilinin-1 | | 著者 | Guddat, L.W, Millers, E.K, de jersey, J, Lavin, M.F, Masci, P.M. | | 登録日 | 2011-11-05 | | 公開日 | 2012-12-26 | | 最終更新日 | 2013-07-17 | | 実験手法 | X-RAY DIFFRACTION (2.777 Å) | | 主引用文献 | The structure of human microplasmin in complex with textilinin-1, an aprotinin-like inhibitor from the Australian brown snake.
Plos One, 8, 2013
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4TPI
 | | THE REFINED 2.2-ANGSTROMS (0.22-NM) X-RAY CRYSTAL STRUCTURE OF THE TERNARY COMPLEX FORMED BY BOVINE TRYPSINOGEN, VALINE-VALINE AND THE ARG15 ANALOGUE OF BOVINE PANCREATIC TRYPSIN INHIBITOR | | 分子名称: | BOVINE PANCREATIC TRYPSIN INHIBITOR, CALCIUM ION, SULFATE ION, ... | | 著者 | Bode, W, Walter, J. | | 登録日 | 1985-06-11 | | 公開日 | 1985-11-08 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The refined 2.2-A (0.22-nm) X-ray crystal structure of the ternary complex formed by bovine trypsinogen, valine-valine and the Arg15 analogue of bovine pancreatic trypsin inhibitor
Eur.J.Biochem., 144, 1984
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4U32
 | | Human mesotrypsin complexed with HAI-2 Kunitz domain 1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Kunitz-type protease inhibitor 2, ... | | 著者 | Wang, R, Soares, A.S, Radisky, E.S. | | 登録日 | 2014-07-18 | | 公開日 | 2014-10-15 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Sequence and Conformational Specificity in Substrate Recognition: SEVERAL HUMAN KUNITZ PROTEASE INHIBITOR DOMAINS ARE SPECIFIC SUBSTRATES OF MESOTRYPSIN.
J.Biol.Chem., 289, 2014
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4U30
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5NX1
 | | Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy | | 分子名称: | Amyloid-beta A4 protein, Kallikrein-6 | | 著者 | Shahar, A, Sananes, A, Radisky, E.S, Papo, N. | | 登録日 | 2017-05-09 | | 公開日 | 2018-05-30 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.853 Å) | | 主引用文献 | A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering.
J.Biol.Chem., 293, 2018
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5NX3
 | | Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy | | 分子名称: | Amyloid-beta A4 protein, Kallikrein-6 | | 著者 | Shahar, A, Sananes, A, Radisky, E.S, Papo, N. | | 登録日 | 2017-05-09 | | 公開日 | 2018-05-30 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.296 Å) | | 主引用文献 | A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering.
J.Biol.Chem., 293, 2018
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4NTY
 | | Cesium sites in the crystal structure of acid-sensing ion channel in complex with snake toxin | | 分子名称: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Acid-sensing ion channel 1, Basic phospholipase A2 homolog Tx-beta, ... | | 著者 | Baconguis, I, Bohlen, C.J, Goehring, A, Julius, D, Gouaux, E. | | 登録日 | 2013-12-02 | | 公開日 | 2014-02-19 | | 最終更新日 | 2019-12-25 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | X-ray structure of Acid-sensing ion channel 1-snake toxin complex reveals open state of a na(+)-selective channel.
Cell(Cambridge,Mass.), 156, 2014
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2TPI
 | | ON THE DISORDERED ACTIVATION DOMAIN IN TRYPSINOGEN. CHEMICAL LABELLING AND LOW-TEMPERATURE CRYSTALLOGRAPHY | | 分子名称: | ISOLEUCINE, MERCURY (II) ION, TRYPSIN INHIBITOR, ... | | 著者 | Walter, J, Steigemann, W, Singh, T.P, Bartunik, H, Bode, W, Huber, R. | | 登録日 | 1981-10-26 | | 公開日 | 1982-03-04 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | On the Disordered Activation Domain in Trypsinogen. Chemical Labelling and Low-Temperature Crystallography
Acta Crystallogr.,Sect.B, 38, 1982
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4ISO
 | | Crystal Structure of Matriptase in complex with its inhibitor HAI-1 | | 分子名称: | DI(HYDROXYETHYL)ETHER, GLUTATHIONE, GLYCEROL, ... | | 著者 | Huang, M.D, Zhao, B.Y, Yuan, C, Li, R. | | 登録日 | 2013-01-16 | | 公開日 | 2013-03-06 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1.
J.Biol.Chem., 288, 2013
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5JBT
 | | Mesotrypsin in complex with cleaved amyloid precursor like protein 2 inhibitor (APLP2) | | 分子名称: | Amyloid-like protein 2, CALCIUM ION, PRSS3 protein, ... | | 著者 | Kayode, O, Wang, R, Pendlebury, D, Soares, A, Radisky, E.S. | | 登録日 | 2016-04-13 | | 公開日 | 2016-11-09 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | An Acrobatic Substrate Metamorphosis Reveals a Requirement for Substrate Conformational Dynamics in Trypsin Proteolysis.
J. Biol. Chem., 291, 2016
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