4ISL

Crystal Structure of the inactive Matriptase in complex with its inhibitor HAI-1

Summary for 4ISL

Entry DOI	10.2210/pdb4isl/pdb
Related	4IS5 4ISN 4ISO
Descriptor	Kunitz-type protease inhibitor 1, Suppressor of tumorigenicity 14 protein, TETRAETHYLENE GLYCOL, ... (7 entities in total)
Functional Keywords	beta barrel, serine protease inhibitor, epithelium, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Secreted: O43278 Membrane ; Single-pass type II membrane protein : Q9Y5Y6
Total number of polymer chains	2
Total formula weight	34331.61
Authors	Huang, M.D.,Zhao, B.Y.,Yuan, C.,Li, R. (deposition date: 2013-01-16, release date: 2013-03-06, Last modification date: 2023-09-20)
Primary citation	Zhao, B.,Yuan, C.,Li, R.,Qu, D.,Huang, M.,Ngo, J.C. Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1. J.Biol.Chem., 288:11155-11164, 2013 Cited by PubMed: 23443661 DOI: 10.1074/jbc.M113.454611 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.29 Å)

Structure validation