7FBA
 
 | | De Novo-Designed and Disulfide-Bridged Peptide Heterodimer - hd2 | | 分子名称: | ALA-LE1-CYS-GLU-CYS-GLY-PRO-THR-ARG-GLU-CYS-LYS-NH2, GLU-CYS-ARG-GLU-TYR-GLY-PRO-LE1-LYS-LE1-LE1-ALA-NH2 | | 著者 | Yao, H, Yao, S, Moyer, A, Zheng, Y, Baker, D, Wu, C. | | 登録日 | 2021-07-08 | | 公開日 | 2022-05-18 | | 最終更新日 | 2023-11-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | De novo design and directed folding of disulfide-bridged peptide heterodimers.
Nat Commun, 13, 2022
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7FB8
 | | De Novo-Designed and Disulfide-Bridged Peptide Heterodimer - hd1 | | 分子名称: | ASP-ASP-LYS-ASP-CYS-ASP-GLU-TYR-CYS-LYS-LYS-THR-LYS-GLU-NH2, GLU-LE1-THR-GLY-HIS-ILE-GLU-GLY-PRO-THR-LE1-THR-LE1-HIS-CYS-LYS-NH2 | | 著者 | Yao, H, Yao, S, Zheng, Y, Moyer, A, Baker, D, Wu, C. | | 登録日 | 2021-07-08 | | 公開日 | 2022-05-18 | | 最終更新日 | 2023-11-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | De novo design and directed folding of disulfide-bridged peptide heterodimers.
Nat Commun, 13, 2022
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1VRZ
 | | Helix turn helix motif | | 分子名称: | ACETATE ION, DE NOVO DESIGNED 21 RESIDUE PEPTIDE | | 著者 | Rudresh, Ramakumar, S, Ramagopal, U.A, Inai, Y, Sahal, D. | | 登録日 | 2005-10-14 | | 公開日 | 2005-11-01 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | | 主引用文献 | De Novo Design and Characterization of a Helical Hairpin Eicosapeptide; Emergence of an Anion Receptor in the Linker Region.
Structure, 12, 2004
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5V2O
 | | De Novo Design of Novel Covalent Constrained Meso-size Peptide Scaffolds with Unique Tertiary Structures | | 分子名称: | 1,3,5-BENZENETRICARBOXYLIC ACID, GLYCEROL, NONAETHYLENE GLYCOL, ... | | 著者 | Dang, B, Wu, H, Mulligan, V.K, Mravic, M, Wu, Y, Lemmin, T, Ford, A, Silva, D, Baker, D, DeGrado, W.F. | | 登録日 | 2017-03-06 | | 公開日 | 2017-10-04 | | 最終更新日 | 2017-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6D0T
 | | De novo design of a fluorescence-activating beta barrel - BB1 | | 分子名称: | BB1 | | 著者 | Dou, J, Vorobieva, A.A, Sheffler, W, Doyle, L.A, Park, H, Bick, M.J, Mao, B, Foight, G.W, Lee, M, Carter, L, Sankaran, B, Ovchinnikov, S, Marcos, E, Huang, P, Vaughan, J.C, Stoddard, B.L, Baker, D. | | 登録日 | 2018-04-10 | | 公開日 | 2018-09-19 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | | 主引用文献 | De novo design of a fluorescence-activating beta-barrel.
Nature, 561, 2018
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5V2G
 | | De Novo Design of Novel Covalent Constrained Meso-size Peptide Scaffolds with Unique Tertiary Structures | | 分子名称: | 1,3,5-tris(bromomethyl)benzene, 20-mer Peptide | | 著者 | Dang, B, Wu, H, Mulligan, V.K, Mravic, M, Wu, Y, Lemmin, T, Ford, A, Silva, D, Baker, D, DeGrado, W.F. | | 登録日 | 2017-03-03 | | 公開日 | 2017-09-27 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5WOD
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6W9Y
 | | De novo designed receptor transmembrane domains enhance CAR-T cytotoxicity and attenuate cytokine release | | 分子名称: | (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, De novo designed receptor transmembrane domain proMP 1.2 | | 著者 | Call, M.J, Call, M.E, Chandler, N.J, Nguyen, J.V, Trenker, R. | | 登録日 | 2020-03-24 | | 公開日 | 2021-03-31 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | De novo designed receptor transmembrane domains enhance CAR-T cytotoxicity and attenuate cytokine release
To Be Published
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6W9Z
 | | De novo designed receptor transmembrane domains enhance CAR-T cytotoxicity and attenuate cytokine release | | 分子名称: | (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, De novo designed receptor transmembrane domain ProMP C2.1 | | 著者 | Call, M.J, Call, M.E, Chandler, N.J, Nguyen, J.V, Trenker, R. | | 登録日 | 2020-03-24 | | 公開日 | 2021-03-31 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | De novo designed receptor transmembrane domains enhance CAR-T cytotoxicity and attenuate cytokine release
To Be Published
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6DG5
 | | Structure of a de novo designed Interleukin-2/Interleukin-15 mimetic complex with IL-2Rb and IL-2Rg | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, ... | | 著者 | Jude, K.M, Silva, D.-A, Yu, S, Baker, D, Garcia, K.C. | | 登録日 | 2018-05-16 | | 公開日 | 2019-01-16 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.516 Å) | | 主引用文献 | De novo design of potent and selective mimics of IL-2 and IL-15.
Nature, 565, 2019
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6DG6
 | | Structure of a de novo designed Interleukin-2/Interleukin-15 mimetic | | 分子名称: | Neoleukin-2/15 | | 著者 | Jude, K.M, Silva, D.-A, Yu, S, Baker, D, Garcia, K.C. | | 登録日 | 2018-05-16 | | 公開日 | 2019-01-16 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.999 Å) | | 主引用文献 | De novo design of potent and selective mimics of IL-2 and IL-15.
Nature, 565, 2019
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7UR7
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7UR8
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7UDJ
 | | Crystal structure of designed helical repeat protein RPB_PEW3_R4 bound to PAWx4 peptide | | 分子名称: | 4xPAW peptide, De novo designed helical repeat protein RPB_PEW3_R4 | | 著者 | Redler, R.L, Chang, Y, Bhabha, G, Ekiert, D. | | 登録日 | 2022-03-20 | | 公開日 | 2023-03-22 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | De novo design of modular peptide-binding proteins by superhelical matching.
Nature, 616, 2023
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8GLT
 | | Backbone model of de novo-designed chlorophyll-binding nanocage O32-15 | | 分子名称: | C2-chlorophyll-comp_O32-15_ctermHis, polyalanine model, C3-comp_O32-15 | | 著者 | Redler, R.L, Ennist, N.M, Wang, S, Baker, D, Ekiert, D.C, Bhabha, G. | | 登録日 | 2023-03-23 | | 公開日 | 2024-03-27 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (6.5 Å) | | 主引用文献 | De novo design of proteins housing excitonically coupled chlorophyll special pairs.
Nat.Chem.Biol., 2024
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7XAD
 | | Crystal strucutre of PD-L1 and DBL2_02 designed protein binder | | 分子名称: | DBL2_02 binder, Programmed cell death 1 ligand 1 | | 著者 | Liu, K.F, Xu, Z.P, Han, P, Pacesa, M, Gao, G.F, Chai, Y, Tan, S.G. | | 登録日 | 2022-03-17 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | De novo design of protein interactions with learned surface fingerprints.
Nature, 617, 2023
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7DKO
 | | De novo design protein AM2M | | 分子名称: | de novo designed protein AM2M | | 著者 | Bin, H. | | 登録日 | 2020-11-25 | | 公開日 | 2021-12-08 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | A backbone-centred energy function of neural networks for protein design.
Nature, 602, 2022
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7DGU
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7DGY
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7DKK
 | | De novo design protein XM2H | | 分子名称: | De novo design protein XM2H | | 著者 | Bin, H. | | 登録日 | 2020-11-24 | | 公開日 | 2021-12-08 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | A backbone-centred energy function of neural networks for protein design.
Nature, 602, 2022
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6EIK
 | | A de novo designed heptameric coiled coil CC-Hept-I24E | | 分子名称: | CC-Hept-I24E, FORMIC ACID, GLYCEROL | | 著者 | Rhys, G.G, Burton, A.J, Dawson, W.M, Thomas, F, Woolfson, D.N. | | 登録日 | 2017-09-19 | | 公開日 | 2018-07-18 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | | 主引用文献 | De Novo-Designed alpha-Helical Barrels as Receptors for Small Molecules.
ACS Synth Biol, 7, 2018
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7Q1S
 | | A de novo designed hetero-dimeric antiparallel coiled coil apCC-Di-AB_var | | 分子名称: | 1,2-ETHANEDIOL, apCC-Di-A_var, apCC-Di-B_var | | 著者 | Shanmugaratnam, S, Rhys, G.G, Dawson, W.M, Woolfson, D.N, Hocker, B. | | 登録日 | 2021-10-20 | | 公開日 | 2022-07-20 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | De novo designed peptides for cellular delivery and subcellular localisation.
Nat.Chem.Biol., 18, 2022
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7Q1T
 | | A de novo designed hetero-dimeric antiparallel coiled coil apCC-Di-AB | | 分子名称: | N-PROPANOL, SULFATE ION, apCC-Di-A, ... | | 著者 | Shanmugaratnam, S, Rhys, G.G, Dawson, W.M, Woolfson, D.N, Hocker, B. | | 登録日 | 2021-10-20 | | 公開日 | 2022-07-20 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | | 主引用文献 | De novo designed peptides for cellular delivery and subcellular localisation.
Nat.Chem.Biol., 18, 2022
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7Q1R
 | | A de novo designed homo-dimeric antiparallel coiled coil apCC-Di | | 分子名称: | ETHANOL, SODIUM ION, apCC-Di | | 著者 | Shanmugaratnam, S, Rhys, G.G, Dawson, W.M, Woolfson, D.N, Hocker, B. | | 登録日 | 2021-10-20 | | 公開日 | 2022-07-20 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.08 Å) | | 主引用文献 | De novo designed peptides for cellular delivery and subcellular localisation.
Nat.Chem.Biol., 18, 2022
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7UEK
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