5V2O
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![BU of 5v2o by Molmil](/molmil-images/mine/5v2o) | De Novo Design of Novel Covalent Constrained Meso-size Peptide Scaffolds with Unique Tertiary Structures | 分子名称: | 1,3,5-BENZENETRICARBOXYLIC ACID, GLYCEROL, NONAETHYLENE GLYCOL, ... | 著者 | Dang, B, Wu, H, Mulligan, V.K, Mravic, M, Wu, Y, Lemmin, T, Ford, A, Silva, D, Baker, D, DeGrado, W.F. | 登録日 | 2017-03-06 | 公開日 | 2017-10-04 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5V2G
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![BU of 5v2g by Molmil](/molmil-images/mine/5v2g) | De Novo Design of Novel Covalent Constrained Meso-size Peptide Scaffolds with Unique Tertiary Structures | 分子名称: | 1,3,5-tris(bromomethyl)benzene, 20-mer Peptide | 著者 | Dang, B, Wu, H, Mulligan, V.K, Mravic, M, Wu, Y, Lemmin, T, Ford, A, Silva, D, Baker, D, DeGrado, W.F. | 登録日 | 2017-03-03 | 公開日 | 2017-09-27 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5WOD
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5FOZ
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![BU of 5foz by Molmil](/molmil-images/mine/5foz) | De novo structure of the binary mosquito larvicide BinAB at pH 10 | 分子名称: | LARVICIDAL TOXIN PROTEIN, SODIUM ION, TOXIN | 著者 | Colletier, J.P, Sawaya, M.R, Gingery, M, Rodriguez, J.A, Cascio, D, Brewster, A.S, Michels-Clark, T, Boutet, S, Williams, G.J, Messerschmidt, M, DePonte, D.P, Sierra, R.G, Laksmono, H, Koglin, J.E, Hunter, M.S, W Park, H, Uervirojnangkoorn, M, Bideshi, D.L, Brunger, A.T, Federici, B.A, Sauter, N.K, Eisenberg, D.S. | 登録日 | 2015-11-26 | 公開日 | 2016-10-05 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | De Novo Phasing with X-Ray Laser Reveals Mosquito Larvicide Binab Structure. Nature, 539, 2016
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5FOY
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![BU of 5foy by Molmil](/molmil-images/mine/5foy) | De novo structure of the binary mosquito larvicide BinAB at pH 7 | 分子名称: | 41.9 KDA INSECTICIDAL TOXIN, LARVICIDAL TOXIN 51 KDA PROTEIN | 著者 | Colletier, J.P, Sawaya, M.R, Gingery, M, Rodriguez, J.A, Cascio, D, Brewster, A.S, Michels-Clark, T, Boutet, S, Williams, G.J, Messerschmidt, M, DePonte, D.P, Sierra, R.G, Laksmono, H, Koglin, J.E, Hunter, M.S, W Park, H, Uervirojnangkoorn, M, Bideshi, D.L, Brunger, A.T, Federici, B.A, Sauter, N.K, Eisenberg, D.S. | 登録日 | 2015-11-26 | 公開日 | 2016-10-05 | 最終更新日 | 2019-08-28 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | De Novo Phasing with X-Ray Laser Reveals Mosquito Larvicide Binab Structure. Nature, 539, 2016
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6D0T
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![BU of 6d0t by Molmil](/molmil-images/mine/6d0t) | De novo design of a fluorescence-activating beta barrel - BB1 | 分子名称: | BB1 | 著者 | Dou, J, Vorobieva, A.A, Sheffler, W, Doyle, L.A, Park, H, Bick, M.J, Mao, B, Foight, G.W, Lee, M, Carter, L, Sankaran, B, Ovchinnikov, S, Marcos, E, Huang, P, Vaughan, J.C, Stoddard, B.L, Baker, D. | 登録日 | 2018-04-10 | 公開日 | 2018-09-19 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | De novo design of a fluorescence-activating beta-barrel. Nature, 561, 2018
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1VRZ
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![BU of 1vrz by Molmil](/molmil-images/mine/1vrz) | Helix turn helix motif | 分子名称: | ACETATE ION, DE NOVO DESIGNED 21 RESIDUE PEPTIDE | 著者 | Rudresh, Ramakumar, S, Ramagopal, U.A, Inai, Y, Sahal, D. | 登録日 | 2005-10-14 | 公開日 | 2005-11-01 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | 主引用文献 | De Novo Design and Characterization of a Helical Hairpin Eicosapeptide; Emergence of an Anion Receptor in the Linker Region. Structure, 12, 2004
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6N9H
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![BU of 6n9h by Molmil](/molmil-images/mine/6n9h) | De novo designed homo-trimeric amantadine-binding protein | 分子名称: | (3S,5S,7S)-tricyclo[3.3.1.1~3,7~]decan-1-amine, SODIUM ION, amantadine-binding protein | 著者 | Park, J, Baker, D. | 登録日 | 2018-12-03 | 公開日 | 2019-12-18 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.039 Å) | 主引用文献 | De novo design of a homo-trimeric amantadine-binding protein. Elife, 8, 2019
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7Q1Q
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![BU of 7q1q by Molmil](/molmil-images/mine/7q1q) | De novo designed homo-dimeric antiparallel helices Homomer-S | 分子名称: | ACETATE ION, Homomer-S | 著者 | Shanmugaratnam, S, Rhys, G.G, Dawson, W.M, Woolfson, D.N, Hocker, B. | 登録日 | 2021-10-20 | 公開日 | 2022-07-20 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1 Å) | 主引用文献 | De novo designed peptides for cellular delivery and subcellular localisation. Nat.Chem.Biol., 18, 2022
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6DG5
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![BU of 6dg5 by Molmil](/molmil-images/mine/6dg5) | Structure of a de novo designed Interleukin-2/Interleukin-15 mimetic complex with IL-2Rb and IL-2Rg | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, ... | 著者 | Jude, K.M, Silva, D.-A, Yu, S, Baker, D, Garcia, K.C. | 登録日 | 2018-05-16 | 公開日 | 2019-01-16 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.516 Å) | 主引用文献 | De novo design of potent and selective mimics of IL-2 and IL-15. Nature, 565, 2019
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8GLT
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![BU of 8glt by Molmil](/molmil-images/mine/8glt) | Backbone model of de novo-designed chlorophyll-binding nanocage O32-15 | 分子名称: | C2-chlorophyll-comp_O32-15_ctermHis, polyalanine model, C3-comp_O32-15 | 著者 | Redler, R.L, Ennist, N.M, Wang, S, Baker, D, Ekiert, D.C, Bhabha, G. | 登録日 | 2023-03-23 | 公開日 | 2024-03-27 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (6.5 Å) | 主引用文献 | De novo design of proteins housing excitonically coupled chlorophyll special pairs. Nat.Chem.Biol., 2024
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5BVL
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7UDJ
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![BU of 7udj by Molmil](/molmil-images/mine/7udj) | Crystal structure of designed helical repeat protein RPB_PEW3_R4 bound to PAWx4 peptide | 分子名称: | 4xPAW peptide, De novo designed helical repeat protein RPB_PEW3_R4 | 著者 | Redler, R.L, Chang, Y, Bhabha, G, Ekiert, D. | 登録日 | 2022-03-20 | 公開日 | 2023-03-22 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | De novo design of modular peptide-binding proteins by superhelical matching. Nature, 616, 2023
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7UR7
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7UR8
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7XAD
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![BU of 7xad by Molmil](/molmil-images/mine/7xad) | Crystal strucutre of PD-L1 and DBL2_02 designed protein binder | 分子名称: | DBL2_02 binder, Programmed cell death 1 ligand 1 | 著者 | Liu, K.F, Xu, Z.P, Han, P, Pacesa, M, Gao, G.F, Chai, Y, Tan, S.G. | 登録日 | 2022-03-17 | 公開日 | 2023-04-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | De novo design of protein interactions with learned surface fingerprints. Nature, 617, 2023
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5C2M
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![BU of 5c2m by Molmil](/molmil-images/mine/5c2m) | The de novo evolutionary emergence of a symmetrical protein is shaped by folding constraints | 分子名称: | Predicted protein | 著者 | Smock, R.G, Yadid, I, Dym, O, Clarke, J, Tawfik, D.S. | 登録日 | 2015-06-16 | 公開日 | 2016-02-03 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints. Cell, 164, 2016
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5C2N
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![BU of 5c2n by Molmil](/molmil-images/mine/5c2n) | The de novo evolutionary emergence of a symmetrical protein is shaped by folding constraints | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta propeller | 著者 | Smock, R.G, Yadid, I, Dym, O, Clarke, J, Tawfik, D.S. | 登録日 | 2015-06-16 | 公開日 | 2016-01-20 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints. Cell, 164, 2016
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6DG6
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![BU of 6dg6 by Molmil](/molmil-images/mine/6dg6) | Structure of a de novo designed Interleukin-2/Interleukin-15 mimetic | 分子名称: | Neoleukin-2/15 | 著者 | Jude, K.M, Silva, D.-A, Yu, S, Baker, D, Garcia, K.C. | 登録日 | 2018-05-16 | 公開日 | 2019-01-16 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.999 Å) | 主引用文献 | De novo design of potent and selective mimics of IL-2 and IL-15. Nature, 565, 2019
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7DKO
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![BU of 7dko by Molmil](/molmil-images/mine/7dko) | De novo design protein AM2M | 分子名称: | de novo designed protein AM2M | 著者 | Bin, H. | 登録日 | 2020-11-25 | 公開日 | 2021-12-08 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | A backbone-centred energy function of neural networks for protein design. Nature, 602, 2022
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7DGU
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7DKK
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![BU of 7dkk by Molmil](/molmil-images/mine/7dkk) | De novo design protein XM2H | 分子名称: | De novo design protein XM2H | 著者 | Bin, H. | 登録日 | 2020-11-24 | 公開日 | 2021-12-08 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A backbone-centred energy function of neural networks for protein design. Nature, 602, 2022
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7DGY
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6EIZ
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![BU of 6eiz by Molmil](/molmil-images/mine/6eiz) | A de novo designed hexameric coiled coil CC-Hex2 with farnesol bound in the channel. | 分子名称: | (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol, CC-Hex2 | 著者 | Rhys, G.G, Burton, A.J, Dawson, W.M, Thomas, F, Woolfson, D.N. | 登録日 | 2017-09-19 | 公開日 | 2018-07-11 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | De Novo-Designed alpha-Helical Barrels as Receptors for Small Molecules. ACS Synth Biol, 7, 2018
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6EIK
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![BU of 6eik by Molmil](/molmil-images/mine/6eik) | A de novo designed heptameric coiled coil CC-Hept-I24E | 分子名称: | CC-Hept-I24E, FORMIC ACID, GLYCEROL | 著者 | Rhys, G.G, Burton, A.J, Dawson, W.M, Thomas, F, Woolfson, D.N. | 登録日 | 2017-09-19 | 公開日 | 2018-07-18 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | De Novo-Designed alpha-Helical Barrels as Receptors for Small Molecules. ACS Synth Biol, 7, 2018
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