6W9Z

De novo designed receptor transmembrane domains enhance CAR-T cytotoxicity and attenuate cytokine release

Summary for 6W9Z

• Entry DOI: 10.2210/pdb6w9z/pdb
• Descriptor: De novo designed receptor transmembrane domain ProMP C2.1, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate (3 entities in total)
• Functional Keywords: transmembrane domain, de novo design, biosynthetic protein
• Biological source: synthetic construct
• Total number of polymer chains: 6
• Total formula weight: 21805.02

Authors

Call, M.J.,Call, M.E.,Chandler, N.J.,Nguyen, J.V.,Trenker, R. (deposition date: 2020-03-24, release date: 2021-03-31, Last modification date: 2023-10-18)

• Primary citation: Elazar, A.,Chandler, N.J.,Davey, A.S.,Weinstein, J.Y.,Nguyen, J.V.,Trenker, R.,Jenkins, M.,Call, M.J.,Call, M.E.,Fleishman, S.J.; De novo designed receptor transmembrane domains enhance CAR-T cytotoxicity and attenuate cytokine release; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.7 Å)