6EQ2
| MTH1 in complex with fragment 6 | 分子名称: | 1~{H}-imidazo[4,5-b]pyridin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase | 著者 | Wiedmer, L, Sledz, P, Caflisch, A. | 登録日 | 2017-10-12 | 公開日 | 2018-10-31 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.802 Å) | 主引用文献 | Ligand retargeting by binding site analogy. Eur.J.Med.Chem., 175, 2019
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8REC
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6EQ7
| MTH1 in complex with fragment 11 | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, 7-(3-fluoranylpyridin-4-yl)-1~{H}-imidazo[4,5-b]pyridin-2-amine, SULFATE ION | 著者 | Wiedmer, L, Sledz, P, Caflisch, A. | 登録日 | 2017-10-12 | 公開日 | 2018-10-31 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Ligand retargeting by binding site analogy. Eur.J.Med.Chem., 175, 2019
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5TC6
| Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with propylthio-immucillin-A | 分子名称: | (2S,3S,4R,5S)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-[(propylsulfanyl)methyl]pyrrolidine-3,4-diol, CHLORIDE ION, GLYCEROL, ... | 著者 | Cameron, S.A, Firestone, R.S, Schramm, V.L, Almo, S.C. | 登録日 | 2016-09-14 | 公開日 | 2017-10-11 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | TBA To be published
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5TC7
| Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with 5'-methylthiotubercidin at 1.75 angstrom | 分子名称: | 2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-METHYLSULFANYLMETHYL-TETRAHYDRO-FURAN-3,4-DIOL, CHLORIDE ION, PHOSPHATE ION, ... | 著者 | Cameron, S.A, Firestone, R.S, Schramm, V.L, Almo, S.C. | 登録日 | 2016-09-14 | 公開日 | 2017-10-11 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | TBA To be published
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1MWA
| 2C/H-2KBM3/DEV8 ALLOGENEIC COMPLEX | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2C T CELL RECEPTOR ALPHA CHAIN, ... | 著者 | Luz, J.G, Huang, M.D, Garcia, K.C, Rudolph, M.G, Teyton, L, Wilson, I.A. | 登録日 | 2002-09-27 | 公開日 | 2002-11-27 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility
complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially
increasing V(beta) Interactions. J.EXP.MED., 195, 2002
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5TFR
| Crystal structure of Zika Virus NS5 protein | 分子名称: | Genome polyprotein, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION | 著者 | Longenecker, K.L, Upadhyay, A.K. | 登録日 | 2016-09-26 | 公開日 | 2016-10-12 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5. Acta Crystallogr F Struct Biol Commun, 73, 2017
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5OE7
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5O90
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5O9D
| Crystal structure of R. ruber ADH-A, mutant Y294F, W295A, Y54F, F43H, H39Y | 分子名称: | (2~{S})-2-methylpentanedioic acid, Alcohol dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Dobritzsch, D, Maurer, D, Hamnevik, E, Enugala, T.R, Widersten, M. | 登録日 | 2017-06-19 | 公開日 | 2017-10-11 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Relaxation of nonproductive binding and increased rate of coenzyme release in an alcohol dehydrogenase increases turnover with a nonpreferred alcohol enantiomer. FEBS J., 284, 2017
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8RAS
| Plastid-encoded RNA polymerase transcription elongation complex | 分子名称: | DNA (81-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Webster, M.W, Pramanick, I, Vergara-Cruces, A. | 登録日 | 2023-12-01 | 公開日 | 2024-03-06 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (2.62 Å) | 主引用文献 | Structure of the plant plastid-encoded RNA polymerase. Cell, 187, 2024
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7BX7
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7V9A
| biogenesis module of human telomerase holoenzyme | 分子名称: | H/ACA ribonucleoprotein complex subunit 1, H/ACA ribonucleoprotein complex subunit 2, H/ACA ribonucleoprotein complex subunit 3, ... | 著者 | Wan, F, Ding, Y, Yang, L, Wu, Z, Wu, J, Lei, M. | 登録日 | 2021-08-24 | 公開日 | 2022-03-30 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.94 Å) | 主引用文献 | Zipper head mechanism of telomere synthesis by human telomerase. Cell Res., 31, 2021
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1JF1
| Crystal structure of HLA-A2*0201 in complex with a decameric altered peptide ligand from the MART-1/Melan-A | 分子名称: | HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-2 ALPHA CHAIN, ZINC ION, ... | 著者 | Sliz, P, Michielin, O, Cerottini, J.C, Luescher, I, Romero, P, Karplus, M, Wiley, D.C. | 登録日 | 2001-06-19 | 公開日 | 2001-09-14 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystal structures of two closely related but antigenically distinct HLA-A2/melanocyte-melanoma tumor-antigen peptide complexes. J.Immunol., 167, 2001
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1JGD
| HLA-B*2709 bound to deca-peptide s10R | 分子名称: | BETA-2-MICROGLOBULIN, GLYCEROL, HUMAN LYMPHOCYTE ANTIGEN HLA-B27, ... | 著者 | Hillig, R.C, Huelsmeyer, M, Saenger, W, Volz, A, Uchanska-Ziegler, B, Ziegler, A. | 登録日 | 2001-06-25 | 公開日 | 2003-07-01 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Thermodynamic and structural analysis
of peptide- and allele-dependent properties
of two HLA-B27 subtypes exhibiting differential disease
association J.Biol.Chem., 279, 2004
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6EQ3
| MTH1 in complex with fragment 9 | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION, [2-(1~{H}-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-4-yl]methanol | 著者 | Wiedmer, L, Sledz, P, Caflisch, A. | 登録日 | 2017-10-12 | 公開日 | 2018-10-31 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.798 Å) | 主引用文献 | Ligand retargeting by binding site analogy. Eur.J.Med.Chem., 175, 2019
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6EQ5
| MTH1 in complex with fragment 4 | 分子名称: | 1H-benzimidazol-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION | 著者 | Wiedmer, L, Sledz, P, Caflisch, A. | 登録日 | 2017-10-12 | 公開日 | 2018-10-31 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | 主引用文献 | Ligand retargeting by binding site analogy. Eur.J.Med.Chem., 175, 2019
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1JHT
| Crystal structure of HLA-A2*0201 in complex with a nonameric altered peptide ligand (ALGIGILTV) from the MART-1/Melan-A. | 分子名称: | HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-2 ALPHA CHAIN, beta-2-microglobulin, ... | 著者 | Sliz, P, Michielin, O, Karplus, M, Romero, P, Wiley, D. | 登録日 | 2001-06-28 | 公開日 | 2001-09-14 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Crystal structures of two closely related but antigenically distinct HLA-A2/melanocyte-melanoma tumor-antigen peptide complexes. J.Immunol., 167, 2001
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1JIQ
| Crystal Structure of Human Autocrine Motility Factor | 分子名称: | autocrine motility factor | 著者 | Tanaka, N, Haga, A, Uemura, H, Akiyama, H, Funasaka, T, Nagase, H, Raz, A, Nakamura, K.T. | 登録日 | 2001-07-02 | 公開日 | 2002-06-19 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Inhibition mechanism of cytokine activity of human autocrine motility factor examined by crystal structure analyses and site-directed mutagenesis studies. J.Mol.Biol., 318, 2002
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1JK9
| Heterodimer between H48F-ySOD1 and yCCS | 分子名称: | SULFATE ION, ZINC ION, copper chaperone for superoxide dismutase, ... | 著者 | Lamb, A.L, Torres, A.S, O'Halloran, T.V, Rosenzweig, A.C. | 登録日 | 2001-07-11 | 公開日 | 2001-09-05 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Heterodimeric structure of superoxide dismutase in complex with its metallochaperone. Nat.Struct.Biol., 8, 2001
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1JPG
| Crystal Structure Of The LCMV Peptidic Epitope Np396 In Complex With The Murine Class I Mhc Molecule H-2Db | 分子名称: | BETA-2-MICROGLOBULIN, H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, D-B ALPHA CHAIN, ... | 著者 | Ciatto, C, Tissot, A.C, Tschopp, M, Capitani, G, Pecorari, F, Pluckthun, A, Grutter, M.G. | 登録日 | 2001-08-02 | 公開日 | 2001-10-24 | 最終更新日 | 2022-12-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Zooming in on the hydrophobic ridge of H-2D(b): implications for the conformational variability of bound peptides. J.Mol.Biol., 312, 2001
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8OPQ
| Structure of Human Solute Carrier 26 family member A6 (SLC26A6) anion transporter in an inward-facing state | 分子名称: | CHLORIDE ION, Solute carrier family 26 member 6 | 著者 | Tippett, D.N, Breen, C, Butler, S.J, Sawicka, M, Dutzler, R. | 登録日 | 2023-04-07 | 公開日 | 2023-05-17 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | 主引用文献 | Structural and functional properties of the transporter SLC26A6 reveal mechanism of coupled anion exchange. Elife, 12, 2023
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1JNJ
| NMR solution structure of the human beta2-microglobulin | 分子名称: | beta2-microglobulin | 著者 | Verdone, G, Corazza, A, Viglino, P, Pettirossi, F, Giorgetti, S, Mangione, P, Andreola, A, Stoppini, M, Bellotti, V, Esposito, G. | 登録日 | 2001-07-24 | 公開日 | 2002-02-27 | 最終更新日 | 2022-02-23 | 実験手法 | SOLUTION NMR | 主引用文献 | The solution structure of human beta2-microglobulin reveals the prodromes of its amyloid transition. Protein Sci., 11, 2002
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7DV6
| Discovery of Functionally Selective Transforming Growth Factor beta Type II Receptor (TGF-beta RII) Inhibitors as Anti-Fibrosis Agents | 分子名称: | 5-[(3S)-5,5-dimethyloxolan-3-yl]-6-methoxy-3-(2-methoxypyridin-4-yl)pyrazolo[1,5-a]pyrimidine, TGF-beta receptor type-2 | 著者 | Nishihata, J, Nomura, A, Miwa, S, Doi, S, Adachi, T. | 登録日 | 2021-01-12 | 公開日 | 2021-06-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Discovery of Selective Transforming Growth Factor beta Type II Receptor Inhibitors as Antifibrosis Agents. Acs Med.Chem.Lett., 12, 2021
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5V9X
| Structure of Mycobacterium smegmatis helicase Lhr bound to ssDNA and AMP-PNP | 分子名称: | ATP-dependent DNA helicase, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Ordonez, H, Jacewicz, A, Ferrao, R, Shuman, S. | 登録日 | 2017-03-23 | 公開日 | 2017-12-06 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.797 Å) | 主引用文献 | Structure of mycobacterial 3'-to-5' RNA:DNA helicase Lhr bound to a ssDNA tracking strand highlights distinctive features of a novel family of bacterial helicases. Nucleic Acids Res., 46, 2018
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