6EQ7

MTH1 in complex with fragment 11

Summary for 6EQ7

Entry DOI	10.2210/pdb6eq7/pdb
Descriptor	7,8-dihydro-8-oxoguanine triphosphatase, 7-(3-fluoranylpyridin-4-yl)-1~{H}-imidazo[4,5-b]pyridin-2-amine, SULFATE ION, ... (4 entities in total)
Functional Keywords	inhibitor, complex, hydrolase, dna repair, fragment
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	21430.20
Authors	Wiedmer, L.,Sledz, P.,Caflisch, A. (deposition date: 2017-10-12, release date: 2018-10-31, Last modification date: 2019-05-22)
Primary citation	Wiedmer, L.,Scharer, C.,Spiliotopoulos, D.,Hurzeler, M.,Sledz, P.,Caflisch, A. Ligand retargeting by binding site analogy. Eur.J.Med.Chem., 175:107-113, 2019 Cited by PubMed: 31077996 DOI: 10.1016/j.ejmech.2019.04.037 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation