5TFR
Crystal structure of Zika Virus NS5 protein
Summary for 5TFR
| Entry DOI | 10.2210/pdb5tfr/pdb |
| Descriptor | Genome polyprotein, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION, ... (4 entities in total) |
| Functional Keywords | mtase, methyltransferase, polymerase, rdrp, rna-dependent rna polymerase, flavivirus, zika, viral protein |
| Biological source | Zika virus (strain Mr 766) (ZIKV) |
| Cellular location | Capsid protein C: Virion . Peptide pr: Secreted . Small envelope protein M: Virion membrane ; Multi-pass membrane protein . Envelope protein E: Virion membrane ; Multi-pass membrane protein . Non-structural protein 1: Secreted . Non-structural protein 2A: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: Q32ZE1 |
| Total number of polymer chains | 2 |
| Total formula weight | 208186.90 |
| Authors | Longenecker, K.L.,Upadhyay, A.K. (deposition date: 2016-09-26, release date: 2016-10-12, Last modification date: 2023-10-04) |
| Primary citation | Upadhyay, A.K.,Cyr, M.,Longenecker, K.,Tripathi, R.,Sun, C.,Kempf, D.J. Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5. Acta Crystallogr F Struct Biol Commun, 73:116-122, 2017 Cited by PubMed: 28291746DOI: 10.1107/S2053230X17001601 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.05 Å) |
Structure validation
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