5TFR
Crystal structure of Zika Virus NS5 protein
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
A | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
A | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0032259 | biological_process | methylation |
A | 0039694 | biological_process | viral RNA genome replication |
B | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
B | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
B | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0008168 | molecular_function | methyltransferase activity |
B | 0032259 | biological_process | methylation |
B | 0039694 | biological_process | viral RNA genome replication |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 14 |
Details | binding site for residue SAH A 1001 |
Chain | Residue |
A | SER56 |
A | VAL130 |
A | ASP131 |
A | VAL132 |
A | PHE133 |
A | ASP146 |
A | GLY58 |
A | GLY81 |
A | CYS82 |
A | GLY83 |
A | GLY86 |
A | TRP87 |
A | LYS105 |
A | HIS110 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue ZN A 1002 |
Chain | Residue |
A | GLU439 |
A | HIS443 |
A | CYS448 |
A | CYS451 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue ZN A 1003 |
Chain | Residue |
A | HIS714 |
A | CYS730 |
A | CYS849 |
site_id | AC4 |
Number of Residues | 15 |
Details | binding site for residue SAH B 1001 |
Chain | Residue |
B | SER56 |
B | GLY58 |
B | GLY81 |
B | CYS82 |
B | GLY83 |
B | GLY86 |
B | TRP87 |
B | THR104 |
B | LYS105 |
B | HIS110 |
B | VAL130 |
B | ASP131 |
B | VAL132 |
B | PHE133 |
B | ASP146 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue ZN B 1002 |
Chain | Residue |
B | GLU439 |
B | HIS443 |
B | CYS448 |
B | CYS451 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue ZN B 1003 |
Chain | Residue |
B | HIS714 |
B | ASN716 |
B | CYS730 |
B | CYS849 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | ACT_SITE: For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 |
Chain | Residue | Details |
A | LYS61 | |
A | ASP146 | |
A | LYS182 | |
A | GLU218 | |
B | LYS61 | |
B | ASP146 | |
B | LYS182 | |
B | GLU218 |
site_id | SWS_FT_FI2 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 |
Chain | Residue | Details |
A | LYS13 | |
A | ARG213 | |
A | SER215 | |
A | TYR220 | |
B | LYS13 | |
B | LEU16 | |
B | ASN17 | |
B | MET19 | |
B | PHE24 | |
B | LYS28 | |
B | THR104 | |
A | LEU16 | |
B | ILE147 | |
B | SER150 | |
B | ARG213 | |
B | SER215 | |
B | TYR220 | |
A | ASN17 | |
A | MET19 | |
A | PHE24 | |
A | LYS28 | |
A | THR104 | |
A | ILE147 | |
A | SER150 |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:28291746, ECO:0000269|PubMed:28345656 |
Chain | Residue | Details |
A | SER56 | |
A | ASP131 | |
A | VAL132 | |
B | SER56 | |
B | ASP131 | |
B | VAL132 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:28291746 |
Chain | Residue | Details |
A | GLY86 | |
A | TRP87 | |
B | GLY86 | |
B | TRP87 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:27386922, ECO:0000269|PubMed:27399257, ECO:0000269|PubMed:29080786 |
Chain | Residue | Details |
A | LYS105 | |
B | LYS105 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:28345656 |
Chain | Residue | Details |
A | HIS110 | |
B | HIS110 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:A0A024B7W1 |
Chain | Residue | Details |
A | GLU111 | |
A | GLU149 | |
B | GLU111 | |
B | GLU149 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:28291746, ECO:0000269|PubMed:28345656 |
Chain | Residue | Details |
A | ASP146 | |
B | ASP146 |
site_id | SWS_FT_FI9 |
Number of Residues | 14 |
Details | BINDING: BINDING => ECO:0000269|PubMed:28291746, ECO:0000269|PubMed:28345596, ECO:0000269|PubMed:28345656 |
Chain | Residue | Details |
A | GLU439 | |
B | CYS448 | |
B | CYS451 | |
B | HIS714 | |
B | CYS730 | |
B | CYS849 | |
A | HIS443 | |
A | CYS448 | |
A | CYS451 | |
A | HIS714 | |
A | CYS730 | |
A | CYS849 | |
B | GLU439 | |
B | HIS443 |
site_id | SWS_FT_FI10 |
Number of Residues | 6 |
Details | SITE: Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 |
Chain | Residue | Details |
A | LYS61 | |
A | LYS182 | |
A | GLU218 | |
B | LYS61 | |
B | LYS182 | |
B | GLU218 |
site_id | SWS_FT_FI11 |
Number of Residues | 2 |
Details | SITE: Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 |
Chain | Residue | Details |
A | ASP146 | |
B | ASP146 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P03314 |
Chain | Residue | Details |
A | SER56 | |
B | SER56 |