7DV6

Discovery of Functionally Selective Transforming Growth Factor beta Type II Receptor (TGF-beta RII) Inhibitors as Anti-Fibrosis Agents

Summary for 7DV6

• Entry DOI: 10.2210/pdb7dv6/pdb
• Descriptor: TGF-beta receptor type-2, 5-[(3S)-5,5-dimethyloxolan-3-yl]-6-methoxy-3-(2-methoxypyridin-4-yl)pyrazolo[1,5-a]pyrimidine (3 entities in total)
• Functional Keywords: inhibitor, complex, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 37142.11

Authors

Nishihata, J.,Nomura, A.,Miwa, S.,Doi, S.,Adachi, T. (deposition date: 2021-01-12, release date: 2021-06-16, Last modification date: 2023-11-29)

• Primary citation: Miwa, S.,Yokota, M.,Ueyama, Y.,Maeda, K.,Ogoshi, Y.,Seki, N.,Ogawa, N.,Nishihata, J.,Nomura, A.,Adachi, T.,Kitao, Y.,Nozawa, K.,Ishikawa, T.,Ukaji, Y.,Shiozaki, M.; Discovery of Selective Transforming Growth Factor beta Type II Receptor Inhibitors as Antifibrosis Agents.; Acs Med.Chem.Lett., 12:745-751, 2021; PubMed: 34055221; DOI: 10.1021/acsmedchemlett.0c00679

Experimental method

X-RAY DIFFRACTION (2.39 Å)