7DV6
Discovery of Functionally Selective Transforming Growth Factor beta Type II Receptor (TGF-beta RII) Inhibitors as Anti-Fibrosis Agents
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A (A) | TGF-beta receptor type-2 | polymer | 323 | 36787.7 | 1 | UniProt (P37173) Pfam (PF07714) | Homo sapiens (Human) | TGFR-2,TGF-beta type II receptor,Transforming growth factor-beta receptor type II,TbetaR-II |
2 | B (A) | 5-[(3S)-5,5-dimethyloxolan-3-yl]-6-methoxy-3-(2-methoxypyridin-4-yl)pyrazolo[1,5-a]pyrimidine | non-polymer | 354.4 | 1 | Chemie (HJF) | |||
3 | C (A) | water | water | 18.0 | 202 | Chemie (HOH) |
Sequence modifications
A: 237 - 549 (UniProt: P37173)
PDB | External Database | Details |
---|---|---|
Met 235 | - | initiating methionine |
Ala 236 | - | expression tag |
Ala 431 | Glu 431 | engineered mutation |
Ala 433 | Arg 433 | engineered mutation |
Ala 485 | Glu 485 | engineered mutation |
Ala 488 | Lys 488 | engineered mutation |
Ala 493 | Arg 493 | engineered mutation |
Ala 495 | Arg 495 | engineered mutation |
Leu 550 | - | expression tag |
Glu 551 | - | expression tag |
His 552 | - | expression tag |
His 553 | - | expression tag |
His 554 | - | expression tag |
His 555 | - | expression tag |
His 556 | - | expression tag |
His 557 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 36787.7 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 354.4 | |
All* | Total formula weight | 37142.1 |