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7DV6

Discovery of Functionally Selective Transforming Growth Factor beta Type II Receptor (TGF-beta RII) Inhibitors as Anti-Fibrosis Agents

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
TGF-beta receptor type-2polymer32336787.71UniProt (P37173)
Pfam (PF07714)
Homo sapiens (Human)TGFR-2,TGF-beta type II receptor,Transforming growth factor-beta receptor type II,TbetaR-II
2B
(A)
5-[(3S)-5,5-dimethyloxolan-3-yl]-6-methoxy-3-(2-methoxypyridin-4-yl)pyrazolo[1,5-a]pyrimidinenon-polymer354.41Chemie (HJF)
3C
(A)
waterwater18.0202Chemie (HOH)
Sequence modifications
A: 237 - 549 (UniProt: P37173)
PDBExternal DatabaseDetails
Met 235-initiating methionine
Ala 236-expression tag
Ala 431Glu 431engineered mutation
Ala 433Arg 433engineered mutation
Ala 485Glu 485engineered mutation
Ala 488Lys 488engineered mutation
Ala 493Arg 493engineered mutation
Ala 495Arg 495engineered mutation
Leu 550-expression tag
Glu 551-expression tag
His 552-expression tag
His 553-expression tag
His 554-expression tag
His 555-expression tag
His 556-expression tag
His 557-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight36787.7
Non-Polymers*Number of molecules1
Total formula weight354.4
All*Total formula weight37142.1
*Water molecules are not included.

239803

PDB entries from 2025-08-06

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