2M0F
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2ML9
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6IF1
| Crystal structure of Ube2K and K48-linked di-ubiquitin complex | 分子名称: | Ubiquitin, Ubiquitin-conjugating enzyme E2 K | 著者 | Lee, J.-G, Youn, H.-S, Lee, Y, An, J.Y, Park, K.R, Kang, J.Y, Lim, J.J, Eom, S.H. | 登録日 | 2018-09-18 | 公開日 | 2018-11-21 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.466 Å) | 主引用文献 | Crystal structure of the Ube2K/E2-25K and K48-linked di-ubiquitin complex provides structural insight into the mechanism of K48-specific ubiquitin chain synthesis. Biochem. Biophys. Res. Commun., 506, 2018
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2LWP
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4FZY
| Exonuclease X in complex with 12bp blunt-ended dsDNA | 分子名称: | DNA (5'-D(*TP*GP*TP*AP*GP*AP*TP*TP*CP*GP*AP*G)-3'), DNA (5'-D(P*CP*TP*CP*GP*AP*AP*TP*CP*TP*AP*CP*A)-3'), Exodeoxyribonuclease 10, ... | 著者 | Wang, T, Sun, H, Cheng, F, Bi, L, Jiang, T. | 登録日 | 2012-07-08 | 公開日 | 2013-07-03 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Recognition and processing of double-stranded DNA by ExoX, a distributive 3'-5' exonuclease Nucleic Acids Res., 41, 2013
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6ID0
| Cryo-EM structure of a human intron lariat spliceosome prior to Prp43 loaded (ILS1 complex) at 2.9 angstrom resolution | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, CWF19-like protein 2, Cell division cycle 5-like protein, ... | 著者 | Zhang, X, Zhan, X, Yan, C, Shi, Y. | 登録日 | 2018-09-07 | 公開日 | 2019-03-13 | 最終更新日 | 2020-10-14 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structures of the human spliceosomes before and after release of the ligated exon. Cell Res., 29, 2019
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4WNW
| Human Cytochrome P450 2D6 Thioridazine Complex | 分子名称: | 10-{2-[(2R)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine, Cytochrome P450 2D6, NICKEL (II) ION, ... | 著者 | Wang, A, Stout, C.D, Johnson, E.F. | 登録日 | 2014-10-14 | 公開日 | 2015-01-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.299 Å) | 主引用文献 | Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding. J.Biol.Chem., 290, 2015
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5KW6
| Two Tandem RRM Domains of PUF60 Bound to an AdML Pre-mRNA 3' Splice Site Analogue with a Modified Binding-Site Nucleic Acid Base | 分子名称: | DNA (30-MER), Poly(U)-binding-splicing factor PUF60 | 著者 | Crichlow, G.V, Hsiao, H.-H, Albright, R, Lolis, E.J, Braddock, D.T. | 登録日 | 2016-07-15 | 公開日 | 2017-08-23 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60. Plos One, 15, 2020
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8H7G
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2LWI
| Solution structure of H-RasT35S mutant protein in complex with Kobe2601 | 分子名称: | 2-(2,4-dinitrophenyl)-N-(4-fluorophenyl)hydrazinecarbothioamide, GTPase HRas, MAGNESIUM ION, ... | 著者 | Araki, M, Tamura, A, Shima, F, Kataoka, T. | 登録日 | 2012-08-01 | 公開日 | 2013-05-22 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc.Natl.Acad.Sci.USA, 110, 2013
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8HMS
| Crystal Structure of PKM2 mutant C474S | 分子名称: | 1,2-ETHANEDIOL, 1,6-di-O-phosphono-beta-D-fructofuranose, GLYCEROL, ... | 著者 | Upadhyay, S, Kumar, A, Patel, A.K. | 登録日 | 2022-12-05 | 公開日 | 2023-01-11 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural and mechanistic insights into cancer patient-derived mutations in Pyruvate Kinase muscle isoform 2 To Be Published
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8HMQ
| Crystal Structure of PKM2 mutant P403A | 分子名称: | 1,2-ETHANEDIOL, 1,6-di-O-phosphono-beta-D-fructofuranose, GLYCEROL, ... | 著者 | Upadhyay, S, Kumar, A, Patel, A.K. | 登録日 | 2022-12-05 | 公開日 | 2023-01-11 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural and mechanistic insights into cancer patient-derived mutations in Pyruvate Kinase muscle isoform 2 To Be Published
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8HMR
| Crystal Structure of PKM2 mutant L144P | 分子名称: | 1,2-ETHANEDIOL, 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, ... | 著者 | Upadhyay, S, Kumar, A, Patel, A.K. | 登録日 | 2022-12-05 | 公開日 | 2023-01-11 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural and mechanistic insights into cancer patient-derived mutations in Pyruvate Kinase muscle isoform 2 To Be Published
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2MDG
| Solution NMR Structure of Zinc finger protein 423 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR7298F | 分子名称: | ZINC ION, Zinc finger protein 423 | 著者 | Pederson, K, Lee, D, Kohan, E, Janjua, H, Xiao, R, Everett, J.K, Acton, T.B, Montelione, G.T, Prestegard, J.H, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2013-09-10 | 公開日 | 2013-09-25 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution NMR Structure of Zinc finger protein 423 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR7298F To be Published
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8H8C
| Type VI secretion system effector RhsP in its post-autoproteolysis and dimeric form | 分子名称: | C-terminal peptide from Putative Rhs-family protein, Putative Rhs-family protein | 著者 | Tang, L, Dong, S.Q, Rasheed, N, Wu, H.W, Zhou, N.K, Li, H.D, Wang, M.L, Zheng, J, He, J, Chao, W.C.H. | 登録日 | 2022-10-22 | 公開日 | 2023-01-18 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | 主引用文献 | Vibrio parahaemolyticus prey targeting requires autoproteolysis-triggered dimerization of the type VI secretion system effector RhsP. Cell Rep, 41, 2022
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8HMU
| Crystal Structure of PKM2 mutant R516C | 分子名称: | 1,2-ETHANEDIOL, 1,6-di-O-phosphono-beta-D-fructofuranose, GLYCEROL, ... | 著者 | Upadhyay, S, Kumar, A, Patel, A.K. | 登録日 | 2022-12-05 | 公開日 | 2023-01-11 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural and mechanistic insights into cancer patient-derived mutations in Pyruvate Kinase muscle isoform 2 To Be Published
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8H8B
| Type VI secretion system effector RhsP in its pre-autoproteolysis and monomeric form | 分子名称: | Putative Rhs-family protein | 著者 | Tang, L, Dong, S.Q, Rasheed, N, Wu, H.W, Zhou, N.K, Li, H.D, Wang, M.L, Zheng, J, He, J, Chao, W.C.H. | 登録日 | 2022-10-22 | 公開日 | 2023-01-18 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | 主引用文献 | Vibrio parahaemolyticus prey targeting requires autoproteolysis-triggered dimerization of the type VI secretion system effector RhsP. Cell Rep, 41, 2022
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2M6T
| NMR solution structure ensemble of 3-4D mutant domain 11 IGF2R | 分子名称: | Insulin-like growth factor 2 receptor variant | 著者 | Strickland, M, Williams, C, Richards, E, Minnall, L, Crump, M.P, Frago, S, Hughes, J, Garner, L, Hoppe, H, Rezgui, D, Zaccheo, O.J, Prince, S.N, Hassan, A.B, Whittaker, S. | 登録日 | 2013-04-09 | 公開日 | 2014-10-15 | 最終更新日 | 2016-06-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist. Proc.Natl.Acad.Sci.USA, 113, 2016
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8H8A
| Type VI secretion system effector RhsP in its post-autoproteolysis and monomeric form | 分子名称: | C-terminal peptide from Putative Rhs-family protein, Putative Rhs-family protein | 著者 | Tang, L, Dong, S.Q, Rasheed, N, Wu, H.W, Zhou, N.K, Li, H.D, Wang, M.L, Zheng, J, He, J, Chao, W.C.H. | 登録日 | 2022-10-22 | 公開日 | 2023-01-18 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | Vibrio parahaemolyticus prey targeting requires autoproteolysis-triggered dimerization of the type VI secretion system effector RhsP. Cell Rep, 41, 2022
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6EJX
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7S0F
| Isoproterenol bound beta1 adrenergic receptor in complex with heterotrimeric Gi protein | 分子名称: | Beta1-Adrenergic Receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Paknejad, N, Alegre, K.O, Su, M, Lou, J.S, Huang, J, Jordan, K.D, Eng, E.T, Meyerson, J.R, Hite, R.K, Huang, X.Y. | 登録日 | 2021-08-30 | 公開日 | 2021-11-17 | 最終更新日 | 2021-12-01 | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | 主引用文献 | Structural basis and mechanism of activation of two different families of G proteins by the same GPCR. Nat.Struct.Mol.Biol., 28, 2021
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7S0G
| Isoproterenol bound beta1 adrenergic receptor in complex with heterotrimeric Gi/s chimera protein | 分子名称: | Beta1-Adrenergic Receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Paknejad, N, Alegre, K.O, Su, M, Lou, J.S, Huang, J, Jordan, K.D, Eng, E.T, Meyerson, J.R, Hite, R.K, Huang, X.Y. | 登録日 | 2021-08-30 | 公開日 | 2021-11-17 | 最終更新日 | 2021-12-01 | 実験手法 | ELECTRON MICROSCOPY (3.86 Å) | 主引用文献 | Structural basis and mechanism of activation of two different families of G proteins by the same GPCR. Nat.Struct.Mol.Biol., 28, 2021
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7Z3X
| Crystal structure of FIR RRM1-2 Y115F mutant bound to FUSE ssDNA | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*TP*TP*T)-3'), DNA (5'-D(P*GP*TP*())-3'), ... | 著者 | Ni, X, Chaikuad, A, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2022-03-02 | 公開日 | 2022-11-09 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Crystal structure of FIR RRM1-2 Y115F mutant bound to FUSE ssDNA To Be Published
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2DCO
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2DGU
| Solution structure of the RNA binding domain in Heterogeneous nuclear ribonucleoprotein Q | 分子名称: | Heterogeneous nuclear ribonucleoprotein Q | 著者 | Abe, C, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2006-03-15 | 公開日 | 2006-09-15 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the RNA binding domain in Heterogeneous nuclear ribonucleoprotein Q To be Published
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