6EJX

The metal ion-dependent adhesion site (MIDAS) of the alphaMbeta2 integrin Mac-1 I-domain promiscuously and competitively binds multiple ligands in the regulation of Leukocyte function

Summary for 6EJX

Entry DOI	10.2210/pdb6ejx/pdb
Descriptor	Platelet glycoprotein Ib alpha chain, IMIDAZOLE, DI(HYDROXYETHYL)ETHER, ... (7 entities in total)
Functional Keywords	gp1balpha, mac-1, blood clotting
Biological source	Mus musculus (Mouse)
Total number of polymer chains	2
Total formula weight	63550.65
Authors	Emsley, J.,Saleem, M. (deposition date: 2017-09-24, release date: 2018-10-24, Last modification date: 2024-01-17)
Primary citation	Morgan, J.,Saleem, M.,Ng, R.,Armstrong, C.,Wong, S.S.,Caulton, S.G.,Fickling, A.,Williams, H.E.L.,Munday, A.D.,Lopez, J.A.,Searle, M.S.,Emsley, J. Structural basis of the leukocyte integrin Mac-1 I-domain interactions with the platelet glycoprotein Ib. Blood Adv, 3:1450-1459, 2019 Cited by PubMed: 31053572 DOI: 10.1182/bloodadvances.2018027011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation