6EJX
The metal ion-dependent adhesion site (MIDAS) of the alphaMbeta2 integrin Mac-1 I-domain promiscuously and competitively binds multiple ligands in the regulation of Leukocyte function
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue IMD D 301 |
| Chain | Residue |
| D | ALA256 |
| D | PRO257 |
| D | SER260 |
| D | TYR261 |
| D | PRO262 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue PEG D 302 |
| Chain | Residue |
| D | HOH425 |
| D | HOH507 |
| D | HOH567 |
| D | ASN83 |
| D | GLU130 |
| D | TYR132 |
| D | MES303 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MES D 303 |
| Chain | Residue |
| D | TYR63 |
| D | ASP65 |
| D | ASP85 |
| D | PEG302 |
| D | HOH402 |
| D | HOH408 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue IMD A 301 |
| Chain | Residue |
| A | ALA256 |
| A | PRO257 |
| A | SER260 |
| A | TYR261 |
| A | PRO262 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | binding site for residue PEG A 302 |
| Chain | Residue |
| A | ASP108 |
| A | SER110 |
| A | PHE111 |
| A | TYR132 |
| A | GLN134 |
| A | ASN156 |
| A | GOL304 |
| A | HOH410 |
| A | HOH496 |
| A | HOH580 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue PEG A 303 |
| Chain | Residue |
| A | PRO262 |
| A | LYS264 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 304 |
| Chain | Residue |
| A | ASP108 |
| A | GLU130 |
| A | TYR132 |
| A | PEG302 |
| A | POL309 |
| A | HOH492 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 305 |
| Chain | Residue |
| A | ARG163 |
| A | TRP185 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue POL A 306 |
| Chain | Residue |
| A | ARG219 |
| A | GLN223 |
| A | SER260 |
| A | TYR261 |
| A | PRO262 |
| site_id | AD1 |
| Number of Residues | 1 |
| Details | binding site for residue POL A 307 |
| Chain | Residue |
| A | PRO267 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue POL A 308 |
| Chain | Residue |
| A | HIS55 |
| A | HOH508 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue POL A 309 |
| Chain | Residue |
| A | ASN83 |
| A | GOL304 |
| A | MES310 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue MES A 310 |
| Chain | Residue |
| A | TYR63 |
| A | ASP85 |
| A | POL309 |
| A | HOH402 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 60 |
| Details | Domain: {"description":"LRRNT"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"LRR 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"LRR 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"LRR 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"LRR 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"LRR 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"LRR 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"LRR 7"} |
| Chain | Residue | Details |
