6EJX

The metal ion-dependent adhesion site (MIDAS) of the alphaMbeta2 integrin Mac-1 I-domain promiscuously and competitively binds multiple ligands in the regulation of Leukocyte function

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (D, A)	Platelet glycoprotein Ib alpha chain	polymer	278	31139.5	2	UniProt (O35930) Pfam (PF13855)	Mus musculus (Mouse)	Glycoprotein Ibalpha
2	C, F (D, A)	IMIDAZOLE	non-polymer		69.1	2	Chemie (IMD)
3	D, G, H (D, A)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	3	Chemie (PEG)
4	E, O (D, A)	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	2	Chemie (MES)
5	I, J (A)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
6	K, L, M, N (A)	N-PROPANOL	non-polymer		60.1	4	Chemie (POL)
7	P, Q (D, A)	water	water		18.0	516	Chemie (HOH)

Sequence modifications

D, A: 2 - 268 (UniProt: O35930)

PDB	External Database	Details
Arg 1	-	expression tag
Thr 269	-	expression tag
Arg 270	-	expression tag
Thr 271	-	expression tag
Gly 272	-	expression tag
His 273	-	expression tag
His 274	-	expression tag
His 275	-	expression tag
His 276	-	expression tag
His 277	-	expression tag
His 278	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	62279.1
Non-Polymers*	Number of molecules	13
	Total formula weight	1271.6
All*	Total formula weight	63550.7

*Water molecules are not included.