4WNW

Human Cytochrome P450 2D6 Thioridazine Complex

Summary for 4WNW

• Entry DOI: 10.2210/pdb4wnw/pdb
• Related: 2F9Q 3QM4 3TBG 3TDA 4WNT 4WNU 4WNV
• Descriptor: Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, 10-{2-[(2R)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine, ... (5 entities in total)
• Functional Keywords: cyp2d6, p450 2d6, p450, monooxygenase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 109539.93

Authors

Wang, A.,Stout, C.D.,Johnson, E.F. (deposition date: 2014-10-14, release date: 2015-01-14, Last modification date: 2023-09-27)

• Primary citation: Wang, A.,Stout, C.D.,Zhang, Q.,Johnson, E.F.; Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding.; J.Biol.Chem., 290:5092-5104, 2015; PubMed: 25555909; DOI: 10.1074/jbc.M114.627661

Experimental method

X-RAY DIFFRACTION (3.299 Å)