4WNW
Human Cytochrome P450 2D6 Thioridazine Complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Cytochrome P450 2D6 | polymer | 479 | 53730.6 | 2 | UniProt (P10635) Pfam (PF00067) In PDB | Homo sapiens (Human) | CYPIID6,Cytochrome P450-DB1,Debrisoquine 4-hydroxylase |
2 | A, B | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
3 | A, B | 10-{2-[(2R)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine | non-polymer | 370.6 | 2 | Chemie (RTZ) | |||
4 | A, B | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
5 | B | NICKEL (II) ION | non-polymer | 58.7 | 1 | Chemie (NI) |
Sequence modifications
A, B: 34 - 497 (UniProt: P10635)
PDB | External Database | Details |
---|---|---|
Met 23 | - | initiating methionine |
Ala 24 | - | expression tag |
Lys 25 | - | expression tag |
Lys 26 | - | expression tag |
Thr 27 | - | expression tag |
Ser 28 | - | expression tag |
Ser 29 | - | expression tag |
Lys 30 | - | expression tag |
Gly 31 | - | expression tag |
Lys 32 | - | expression tag |
Leu 33 | - | expression tag |
His 498 | - | expression tag |
His 499 | - | expression tag |
His 500 | - | expression tag |
His 501 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 107461.1 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 2078.8 | |
All* | Total formula weight | 109539.9 |