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4WNT

Human Cytochrome P450 2D6 Ajmalicine Complex

Summary for 4WNT
Entry DOI10.2210/pdb4wnt/pdb
Related2F9Q 3QM4 3TBG 3TDA 4WNU 4WNV 4WNW
DescriptorCytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, Ajmalicine, ... (5 entities in total)
Functional Keywordscyp2d6, p450 2d6, cytochrome p450, monooxygenase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight109595.19
Authors
Wang, A.,Stout, C.D.,Johnson, E.F. (deposition date: 2014-10-14, release date: 2015-01-14, Last modification date: 2023-09-27)
Primary citationWang, A.,Stout, C.D.,Zhang, Q.,Johnson, E.F.
Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding.
J.Biol.Chem., 290:5092-5104, 2015
Cited by
PubMed: 25555909
DOI: 10.1074/jbc.M114.627661
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

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