PDB: 36840 件ウェブページステータス検索Chemie searchBIRD

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1K6P	LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE 分子名称: ACETATE ION, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(BENZO[1,3]DIOXOL-5-YLMETHYL)-PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE, POL polyprotein 著者 Schiffer, C.A. 登録日 2001-10-16 公開日 2002-02-06 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Lack of synergy for inhibitors targeting a multi-drug-resistant HIV-1 protease. Protein Sci., 11, 2002
2DL5	Solution structure of the first SH3 domain of human KIAA0769 protein 分子名称: KIAA0769 protein 著者 Qin, X.R, Izumi, K, Yoshida, M, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-04-17 公開日 2006-10-17 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the first SH3 domain of human KIAA0769 protein To be published
2YAA	Crystal structure of the autoinhibited form of mouse DAPK2 in complex with ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DEATH-ASSOCIATED PROTEIN KINASE 2, ... 著者 Patel, A.K, Kursula, P. 登録日 2011-02-18 公開日 2011-04-13 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of the Dimeric Autoinhibited Conformation of Dapk2, a Pro-Apoptotic Protein Kinase. J.Mol.Biol., 409, 2011
3VBY	Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design 分子名称: IMIDAZOLE, Serine/threonine-protein kinase pim-1, furan-2-yl(1H-indol-3-yl)methanone 著者 Liu, J. 登録日 2012-01-02 公開日 2012-03-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. J.Med.Chem., 55, 2012
2A1M	Crystal structure of ferrous dioxygen complex of wild-type cytochrome P450cam 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CAMPHOR, Cytochrome P450-cam, ... 著者 Nagano, S, Poulos, T.L. 登録日 2005-06-20 公開日 2005-07-05 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystallographic study on the dioxygen complex of wild-type and mutant cytochrome P450cam. Implications for the dioxygen activation mechanism J.Biol.Chem., 280, 2005
1YP7	Van der Waals Interactions Dominate Hydrophobic Association in a Protein Binding Site Occluded From Solvent Water 分子名称: CADMIUM ION, MAJOR URINARY PROTEIN 1 著者 Barratt, E, Bingham, R.J, Warner, D.J, Laughton, C.A, Phillips, S.E.V, Homans, S.W. 登録日 2005-01-30 公開日 2005-08-30 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Van der Waals Interactions Dominate Ligand-Protein Association in a Protein Binding Site Occluded from Solvent Water J.Am.Chem.Soc., 127, 2005
1YPO	Human Oxidized Low Density Lipoprotein Receptor LOX-1 P3 1 21 Space Group 分子名称: oxidised low density lipoprotein (lectin-like) receptor 1 著者 Park, H, Adsit, F.G, Boyington, J.C. 登録日 2005-01-31 公開日 2005-02-08 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The 1.4 angstrom crystal structure of the human oxidized low density lipoprotein receptor lox-1. J.Biol.Chem., 280, 2005
1YQJ	Crystal Structure of p38 Alpha in Complex with a Selective Pyridazine Inhibitor 分子名称: 6((S)-3-BENZYLPIPERAZIN-1-YL)-3-(NAPHTHALEN-2-YL)-4-(PYRIDIN-4-YL)PYRAZINE, Mitogen-activated protein kinase 14, SULFATE ION 著者 Tamayo, N, Liao, H, Goldberg, M, Syed, R, Li, V, Powers, D, Tudor, Y, Yu, V, Wong, M.L, Henkle, B, Middelton, S, Harvey, T, Jang, G, Hungate, R, Dominguez, C. 登録日 2005-02-01 公開日 2005-04-26 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase. Bioorg.Med.Chem.Lett., 15, 2005
1YSO	YEAST CU, ZN SUPEROXIDE DISMUTASE WITH THE REDUCED BRIDGE BROKEN 分子名称: COPPER (I) ION, YEAST CU, ZN SUPEROXIDE DISMUTASE, ... 著者 Parge, H.E, Crane, B.R, Tsang, J, Tainer, J.A. 登録日 1995-12-21 公開日 1996-06-10 最終更新日 2018-03-21 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Unusual trigonal-planar copper configuration revealed in the atomic structure of yeast copper-zinc superoxide dismutase. Biochemistry, 35, 1996
3W1F	Crystal structure of Human MPS1 catalytic domain in complex with 5-(5-ethoxy-6-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-3-yl)-2-methylbenzenesulfonamide 分子名称: 5-[5-ethoxy-6-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-3-yl]-2-methylbenzenesulfonamide, Dual specificity protein kinase TTK 著者 Kusakabe, K, Ide, N, Daigo, Y, Tachibana, Y, Itoh, T, Yamamoto, T, Hashizume, H, Hato, Y, Higashino, K, Okano, Y, Sato, Y, Inoue, M, Iguchi, M, Kanazawa, T, Ishioka, Y, Dohi, K, Kido, Y, Sakamoto, S, Yasuo, K, Maeda, M, Higaki, M, Ueda, K, Yoshizawa, H, Baba, Y, Shiota, T, Murai, H, Nakamura, Y. 登録日 2012-11-14 公開日 2013-06-26 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Indazole-based potent and cell-active Mps1 kinase inhibitors: rational design from pan-kinase inhibitor anthrapyrazolone (SP600125) J.Med.Chem., 56, 2013
1K8R	Crystal structure of Ras-Bry2RBD complex 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Protein kinase byr2, ... 著者 Scheffzek, K, Gruenewald, P, Wohlgemuth, S, Kabsch, W, Tu, H, Wigler, M, Wittinghofer, A, Herrmann, C. 登録日 2001-10-25 公開日 2002-03-13 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast. Structure, 9, 2001
2ADR	ADR1 DNA-BINDING DOMAIN FROM SACCHAROMYCES CEREVISIAE, NMR, 25 STRUCTURES 分子名称: ADR1, ZINC ION 著者 Bowers, P.M, Kleivt, R.E. 登録日 1998-03-20 公開日 1998-06-17 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 A folding transition and novel zinc finger accessory domain in the transcription factor ADR1. Nat.Struct.Biol., 6, 1999
1K66	Crystal Structure of the Cyanobacterial Phytochrome Response Regulator, RcpB 分子名称: BETA-MERCAPTOETHANOL, Phytochrome Response Regulator RcpB 著者 Benda, C, Scheufler, C, Tandeau de Marsac, N, Gaertner, W. 登録日 2001-10-15 公開日 2003-12-16 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Crystal structures of two cyanobacterial response regulators in apo- and phosphorylated form reveal a novel dimerization motif of phytochrome-associated response regulators Biophys.J., 87, 2004
1YMC	THREE-DIMENSIONAL STRUCTURE OF CYANOMET-SULFMYOGLOBIN C 分子名称: CYANIDE ION, CYANOMET-SULFMYOGLOBIN, SULFATE ION, ... 著者 Evans, S.V, Brayer, G.D. 登録日 1993-09-27 公開日 1994-01-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Three-dimensional structure of cyanomet-sulfmyoglobin C. Proc.Natl.Acad.Sci.USA, 91, 1994
1K7B	NMR Solution Structure of sTva47, the Viral-Binding Domain of Tva 分子名称: SUBGROUP A ROUS SARCOMA VIRUS RECEPTOR PG800 AND PG950 著者 Tonelli, M, Peters, R.J, James, T.L, Agard, D.A. 登録日 2001-10-18 公開日 2001-12-19 最終更新日 2020-02-05 実験手法 SOLUTION NMR 主引用文献 The solution structure of the viral binding domain of Tva, the cellular receptor for subgroup A avian leukosis and sarcoma virus. FEBS Lett., 509, 2001
2YER	Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors 分子名称: 1,2-ETHANEDIOL, 5-(HYDROXYMETHYL)-8-(1H-PYRROL-2-YL)-2H-[1,2,4]TRIAZOLO[4,3-A]QUINOLIN-1-ONE, SERINE/THREONINE-PROTEIN KINASE CHK1, ... 著者 Read, J.A, Breed, J, Haye, H, McCall, E, Vallentine, A, White, A, Otterbein, L. 登録日 2011-03-30 公開日 2012-03-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Synthesis and Evaluation of Triazolones as Checkpoint Kinase 1 Inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
3UOL	Aurora A in complex with SO2-162 分子名称: 1,2-ETHANEDIOL, Aurora kinase A, N~4~-(2-chlorophenyl)-N~2~-[4-(1H-tetrazol-5-yl)phenyl]pyrimidine-2,4-diamine 著者 Martin, M.P, Zhu, J.-Y, Schonbrunn, E. 登録日 2011-11-16 公開日 2012-01-25 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A. Acs Chem.Biol., 7, 2012
1JRR	HUMAN PLASMINOGEN ACTIVATOR INHIBITOR-2.[LOOP (66-98) DELETIONMUTANT] COMPLEXED WITH PEPTIDE MIMIckING THE REACTIVE CENTER LOOP 分子名称: BETA-MERCAPTOETHANOL, PLASMINOGEN ACTIVATOR INHIBITOR-2 著者 Jankova, L, Harrop, S.J, Saunders, D.N, Andrews, J.L, Bertram, K.C, Gould, A.R, Baker, M.S, Curmi, P.M.G. 登録日 2001-08-15 公開日 2001-09-26 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 CRYSTAL STRUCTURE OF THE COMPLEX OF PLASMINOGEN ACTIVATOR INHIBITOR 2 WITH A PEPTIDE MIMICKING THE REACTIVE CENTER LOOP J.Biol.Chem., 276, 2001
1K2O	Cytochrome P450Cam with Bound BIS(2,2'-BIPYRIDINE)-(5-METHYL-2-2'-BIPYRIDINE)-C2-ADAMANTANE RUTHENIUM (II) 分子名称: CACODYLATE ION, Cytochrome P450CAM, DELTA-BIS(2,2'-BIPYRIDINE)-(5-METHYL-2-2'-BIPYRIDINE)-C2-ADAMANTANE RUTHENIUM (II), ... 著者 Dunn, A.R, Dmochowski, I.J, Bilwes, A.M, Gray, H.B, Crane, B.R. 登録日 2001-09-28 公開日 2001-10-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Probing the open state of cytochrome P450cam with ruthenium-linker substrates. Proc.Natl.Acad.Sci.USA, 98, 2001
1YNZ	SH3 domain of yeast Pin3 分子名称: Pin3p 著者 Kursula, P, Kursula, I, Zou, P, Lehmann, F, Song, Y.H, Wilmanns, M. 登録日 2005-01-26 公開日 2006-05-30 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural analysis of the yeast SH3 domain proteome To be Published
1JS0	Crystal Structure of 3D Domain-swapped RNase A Minor Trimer 分子名称: RIBONUCLEASE A, SULFATE ION 著者 Liu, Y, Gotte, G, Libonati, M, Eisenberg, D. 登録日 2001-08-15 公開日 2002-03-13 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structures of the two 3D domain-swapped RNase A trimers. Protein Sci., 11, 2002
1YRP	Catalytic domain of human ZIP kinase phosphorylated at Thr265 分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Death-associated protein kinase 3 著者 Kursula, P, Vahokoski, J, Wilmanns, M. 登録日 2005-02-04 公開日 2006-06-20 最終更新日 2016-05-18 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Death-Associated Protein Kinase Activity Is Regulated by Coupled Calcium/Calmodulin Binding to Two Distinct Sites Structure, 2016
1ZZZ	Trypsin inhibitors with rigid tripeptidyl aldehydes 分子名称: 2-{(3S)-3-[(benzylsulfonyl)amino]-2-oxopiperidin-1-yl}-N-{(2S)-1-[(3R)-1-carbamimidoylpiperidin-3-yl]-3-oxopropan-2-yl}acetamide, CALCIUM ION, TRYPSIN 著者 Krishnan, R, Zhang, E, Hakansson, K, Arni, R.K, Tulinsky, A, Lim-Wilby, M.S.L, Levy, O.E, Semple, J.E, Brunck, T.K. 登録日 1998-06-02 公開日 1999-06-15 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes. Biochemistry, 37, 1998
1JA3	Crystal Structure of the Murine NK Cell Inhibitory Receptor Ly-49I 分子名称: MHC class I recognition receptor Ly49I 著者 Dimasi, N, Sawicki, W.M, Reineck, L.A, Li, Y, Natarajan, K, Murgulies, D.H, Mariuzza, A.R. 登録日 2001-05-29 公開日 2002-07-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal structure of the Ly49I natural killer cell receptor reveals variability in dimerization mode within the Ly49 family. J.Mol.Biol., 320, 2002
1JBK	Crystal Structure of the First Nucelotide Binding Domain of ClpB 分子名称: CLPB PROTEIN, MAGNESIUM ION 著者 Jingzhi, L, Bingdong, S. 登録日 2001-06-05 公開日 2002-06-05 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of E. coli Hsp100 ClpB nucleotide-binding domain 1 (NBD1) and mechanistic studies on ClpB ATPase activity. J.Mol.Biol., 318, 2002

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