3UOL

Aurora A in complex with SO2-162

Summary for 3UOL

Related3UNJ 3UNK 3UNZ 3UO4 3UO5 3UO6 3UOD 3UOH 3UOJ 3UOK 3UP2 3UP7
DescriptorAurora kinase A, N~4~-(2-chlorophenyl)-N~2~-[4-(1H-tetrazol-5-yl)phenyl]pyrimidine-2,4-diamine, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsprotein kinase, aurora a, inhibitor, dfg-out, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton, centrosome O14965
Total number of polymer chains2
Total molecular weight66192.65
Authors
Martin, M.P.,Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2011-11-16, release date: 2012-01-25, Last modification date: 2012-05-02)
Primary citation
Martin, M.P.,Zhu, J.Y.,Lawrence, H.R.,Pireddu, R.,Luo, Y.,Alam, R.,Ozcan, S.,Sebti, S.M.,Lawrence, N.J.,Schonbrunn, E.
A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A.
Acs Chem.Biol., 7:698-706, 2012
PubMed: 22248356 (PDB entries with the same primary citation)
DOI: 10.1021/cb200508b
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.279350.4%8.2%3.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload