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3UOH

Aurora A in complex with RPM1722

Summary for 3UOH
Entry DOI10.2210/pdb3uoh/pdb
Related3UNJ 3UNK 3UNZ 3UO4 3UO5 3UO6 3UOD 3UOJ 3UOK 3UOL 3UP2 3UP7
DescriptorAurora kinase A, 4-({4-[(2-bromophenyl)amino]pyrimidin-2-yl}amino)benzoic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsprotein kinase, aurora a, inhibitor, dfg-out, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton, centrosome: O14965
Total number of polymer chains2
Total formula weight65799.02
Authors
Martin, M.P.,Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2011-11-16, release date: 2012-01-25, Last modification date: 2023-09-13)
Primary citationMartin, M.P.,Zhu, J.Y.,Lawrence, H.R.,Pireddu, R.,Luo, Y.,Alam, R.,Ozcan, S.,Sebti, S.M.,Lawrence, N.J.,Schonbrunn, E.
A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A.
Acs Chem.Biol., 7:698-706, 2012
Cited by
PubMed: 22248356
DOI: 10.1021/cb200508b
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8002 Å)
Structure validation

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