3UNJ
CDK2 in complex with inhibitor YL1-038-31
Summary for 3UNJ
Entry DOI | 10.2210/pdb3unj/pdb |
Related | 3UNK 3UNZ 3UO4 3UO5 3UO6 3UOD 3UOH 3UOJ 3UOK 3UOL 3UP2 3UP7 |
Descriptor | Cyclin-dependent kinase 2, 4-{[4-(phenylamino)pyrimidin-2-yl]amino}benzoic acid, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | protein kinase, allosteric ligand, ans, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, centrosome: P24941 |
Total number of polymer chains | 1 |
Total formula weight | 34377.78 |
Authors | Zhu, J.-Y.,Martin, M.P.,Alam, R.,Schonbrunn, E. (deposition date: 2011-11-15, release date: 2012-01-25, Last modification date: 2023-09-13) |
Primary citation | Martin, M.P.,Zhu, J.Y.,Lawrence, H.R.,Pireddu, R.,Luo, Y.,Alam, R.,Ozcan, S.,Sebti, S.M.,Lawrence, N.J.,Schonbrunn, E. A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A. Acs Chem.Biol., 7:698-706, 2012 Cited by PubMed: 22248356DOI: 10.1021/cb200508b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9001 Å) |
Structure validation
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