3UP7
Aurora A in complex with YL1-038-09
Summary for 3UP7
Entry DOI | 10.2210/pdb3up7/pdb |
Related | 3UNJ 3UNK 3UNZ 3UO4 3UO5 3UO6 3UOD 3UOH 3UOJ 3UOK 3UOL 3UP2 |
Descriptor | Aurora kinase A, 2-({2-[(4-carboxyphenyl)amino]pyrimidin-4-yl}amino)benzoic acid (3 entities in total) |
Functional Keywords | protein kinase, aurora a, inhibitor, dfg-in, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, centrosome: O14965 |
Total number of polymer chains | 1 |
Total formula weight | 32709.45 |
Authors | Martin, M.P.,Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2011-11-17, release date: 2012-01-25, Last modification date: 2023-09-13) |
Primary citation | Lawrence, H.R.,Martin, M.P.,Luo, Y.,Pireddu, R.,Yang, H.,Gevariya, H.,Ozcan, S.,Zhu, J.Y.,Kendig, R.,Rodriguez, M.,Elias, R.,Cheng, J.Q.,Sebti, S.M.,Schonbrunn, E.,Lawrence, N.J. Development of o-Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase Inhibitors. J.Med.Chem., 55:7392-7416, 2012 Cited by PubMed: 22803810DOI: 10.1021/jm300334d PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.05 Å) |
Structure validation
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