3UO6

Aurora A in complex with YL5-083

Summary for 3UO6

Entry DOI	10.2210/pdb3uo6/pdb
Related	3UNJ 3UNK 3UNZ 3UO4 3UO5 3UOD 3UOH 3UOJ 3UOK 3UOL 3UP2 3UP7
Descriptor	Aurora kinase A, 4-({4-[(2-chlorophenyl)amino]pyrimidin-2-yl}amino)benzoic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	protein kinase, aurora a, inhibitor, dfg-out, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton, centrosome: O14965
Total number of polymer chains	2
Total formula weight	65648.05
Authors	Martin, M.P.,Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2011-11-16, release date: 2012-01-25, Last modification date: 2023-09-13)
Primary citation	Martin, M.P.,Zhu, J.Y.,Lawrence, H.R.,Pireddu, R.,Luo, Y.,Alam, R.,Ozcan, S.,Sebti, S.M.,Lawrence, N.J.,Schonbrunn, E. A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A. Acs Chem.Biol., 7:698-706, 2012 Cited by PubMed: 22248356 DOI: 10.1021/cb200508b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8002 Å)

Structure validation