3UOK
Aurora A in complex with YL5-81-1
Summary for 3UOK
Entry DOI | 10.2210/pdb3uok/pdb |
Related | 3UNJ 3UNK 3UNZ 3UO4 3UO5 3UO6 3UOD 3UOH 3UOJ 3UOL 3UP2 3UP7 |
Descriptor | Aurora kinase A, 4-({4-[(2-chlorophenyl)amino]-5-fluoropyrimidin-2-yl}amino)benzoic acid (3 entities in total) |
Functional Keywords | protein kinase, aurora a, inhibitor, dfg-out, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, centrosome: O14965 |
Total number of polymer chains | 2 |
Total formula weight | 65435.75 |
Authors | Martin, M.P.,Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2011-11-16, release date: 2012-01-25, Last modification date: 2023-09-13) |
Primary citation | Martin, M.P.,Zhu, J.Y.,Lawrence, H.R.,Pireddu, R.,Luo, Y.,Alam, R.,Ozcan, S.,Sebti, S.M.,Lawrence, N.J.,Schonbrunn, E. A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A. Acs Chem.Biol., 7:698-706, 2012 Cited by PubMed: 22248356DOI: 10.1021/cb200508b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9506 Å) |
Structure validation
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