2YER

Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors

Summary for 2YER

Entry DOI	10.2210/pdb2yer/pdb
Related	1IA8 1NVQ 1NVR 1NVS 1ZLT 1ZYS 2AYP 2BR1 2BRB 2BRG 2BRH 2BRM 2BRN 2BRO 2C3J 2C3K 2C3L 2CGU 2CGV 2CGW 2CGX 2WMQ 2WMR 2WMS 2WMT 2WMU 2WMV 2WMW 2WMX 2X8D 2X8E 2X8I 2XEY 2XEZ 2XF0 2YDI 2YDJ 2YDK 2YEX 2YM3 2YM4 2YM5 2YM6 2YM7 2YM8
Descriptor	SERINE/THREONINE-PROTEIN KINASE CHK1, 5-(HYDROXYMETHYL)-8-(1H-PYRROL-2-YL)-2H-[1,2,4]TRIAZOLO[4,3-A]QUINOLIN-1-ONE, SULFATE ION, ... (5 entities in total)
Functional Keywords	transferase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus: O14757
Total number of polymer chains	1
Total formula weight	32589.49
Authors	Read, J.A.,Breed, J.,Haye, H.,McCall, E.,Vallentine, A.,White, A.,Otterbein, L. (deposition date: 2011-03-30, release date: 2012-03-14, Last modification date: 2018-04-04)
Primary citation	Oza, V.,Ashwell, S.,Brassil, P.,Breed, J.,Ezhuthachan, J.,Deng, C.,Grondine, M.,Horn, C.,Liu, D.,Lyne, P.,Newcombe, N.,Pass, M.,Read, J.,Su, M.,Toader, D.,Yu, D.,Yu, Y.,Zabludoff, S. Synthesis and Evaluation of Triazolones as Checkpoint Kinase 1 Inhibitors. Bioorg.Med.Chem.Lett., 22:2330-, 2012 Cited by PubMed: 22342147 DOI: 10.1016/J.BMCL.2012.01.043 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.83 Å)

Structure validation