1MU7
 
 | | Crystal Structure of a Human Tyrosyl-DNA Phosphodiesterase (Tdp1)-Tungstate Complex | | 分子名称: | GLYCEROL, TUNGSTATE(VI)ION, Tyrosyl-DNA Phosphodiesterase | | 著者 | Davies, D.R, Interthal, H, Champoux, J.J, Hol, W.G.J. | | 登録日 | 2002-09-23 | | 公開日 | 2003-01-07 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Insights Into Substrate Binding and Catalytic Mechanism of Human Tyrosyl-DNA Phosphodiesterase (Tdp1) from Vanadate- and Tungstate-Inhibited Structures
J.Mol.Biol., 324, 2003
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1W3N
 | | Sulfolobus solfataricus 2-keto-3-deoxygluconate (KDG) aldolase complex with D-KDG | | 分子名称: | 2-KETO-3-DEOXY GLUCONATE ALDOLASE, 3-DEOXY-D-ARABINO-HEXONIC ACID, GLYCEROL | | 著者 | Theodossis, A, Walden, H, Westwick, E.J, Connaris, H, Lamble, H.J, Hough, D.W, Danson, M.J, Taylor, G.L. | | 登録日 | 2004-07-17 | | 公開日 | 2004-09-02 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The structural basis for substrate promiscuity in 2-keto-3-deoxygluconate aldolase from the Entner-Doudoroff pathway in Sulfolobus solfataricus.
J. Biol. Chem., 279, 2004
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5W3R
 | | SH2B1 SH2 Domain | | 分子名称: | PHENOL, PHOSPHATE ION, SH2B adapter protein 1 | | 著者 | McKercher, M.A, Wuttke, D.S. | | 登録日 | 2017-06-08 | | 公開日 | 2017-11-22 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.386 Å) | | 主引用文献 | Diversity in peptide recognition by the SH2 domain of SH2B1.
Proteins, 86, 2018
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4W81
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1W3U
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1W7J
 | | Crystal Structure Of Myosin V Motor With Essential Light Chain + ADP-BeFx - Near Rigor | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | | 著者 | Coureux, P.-D, Sweeney, H.L, Houdusse, A. | | 登録日 | 2004-09-03 | | 公開日 | 2005-02-22 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Three Myosin V Structures Delineate Essential Features of Chemo-Mechanical Transduction
Embo J., 23, 2004
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6XHW
 | | Crystal structure of the A2058-unmethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.50A resolution | | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Svetlov, M.S, Syroegin, E.A, Aleksandrova, E.V, Atkinson, G.C, Gregory, S.T, Mankin, A.S, Polikanov, Y.S. | | 登録日 | 2020-06-19 | | 公開日 | 2020-12-23 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance.
Nat.Chem.Biol., 17, 2021
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4ZZI
 | | SIRT1/Activator/Inhibitor Complex | | 分子名称: | (3S)-1,3-dimethyl-N-[3-(1,3-oxazol-5-yl)phenyl]-6-[3-(trifluoromethyl)phenyl]-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide, 4-(4-{2-[(methylsulfonyl)amino]ethyl}piperidin-1-yl)thieno[3,2-d]pyrimidine-6-carboxamide, NAD-dependent protein deacetylase sirtuin-1, ... | | 著者 | Dai, H. | | 登録日 | 2015-05-22 | | 公開日 | 2015-07-15 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.7346 Å) | | 主引用文献 | Crystallographic structure of a small molecule SIRT1 activator-enzyme complex.
Nat Commun, 6, 2015
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3VS7
 | | Crystal structure of HCK complexed with a pyrazolo-pyrimidine inhibitor 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | | 分子名称: | 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Kuratani, M, Honda, K, Niwa, H, Toyama, M, Handa, N, Yokoyama, S. | | 登録日 | 2012-04-21 | | 公開日 | 2013-05-01 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (3.001 Å) | | 主引用文献 | A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo
Sci Transl Med, 5, 2013
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6XNU
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2DBU
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5A8F
 | | Structure and genome release mechanism of human cardiovirus Saffold virus-3 | | 分子名称: | GENOME POLYPHUMAN SAFFOLD VIRUS-3 VP3 PROTEIN, HUMAN SAFFOLD VIRUS-3 VP1, HUMAN SAFFOLD VIRUS-3 VP2 | | 著者 | Mullapudi, E, Novacek, J, Palkova, L, Kulich, P, Lindberg, M, vanKuppeveld, F.J.M, Plevka, P. | | 登録日 | 2015-07-15 | | 公開日 | 2016-06-08 | | 最終更新日 | 2019-10-30 | | 実験手法 | ELECTRON MICROSCOPY (10.6 Å) | | 主引用文献 | Structure and Genome Release Mechanism of Human Cardiovirus Saffold Virus-3.
J.Virol., 90, 2016
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5W65
 | | RNA polymerase I Initial Transcribing Complex State 2 | | 分子名称: | DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... | | 著者 | Han, Y, He, Y. | | 登録日 | 2017-06-16 | | 公開日 | 2017-08-02 | | 最終更新日 | 2019-11-27 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Structural mechanism of ATP-independent transcription initiation by RNA polymerase I.
Elife, 6, 2017
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1MWM
 | | ParM from plasmid R1 ADP form | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ParM | | 著者 | Van den Ent, F, Moller-Jensen, J, Amos, L.A, Gerdes, K, Lowe, J. | | 登録日 | 2002-09-30 | | 公開日 | 2003-01-28 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | F-actin-like filaments formed by plasmid segregation protein ParM
EMBO J., 21, 2002
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6XOK
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6XP2
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5W52
 | | MicroED structure of the segment, DLIIKGISVHI, from the RRM2 of TDP-43, residues 247-257 | | 分子名称: | TAR DNA-binding protein 43 | | 著者 | Guenther, E.L, Sawaya, M.R, Cascio, D, Eisenberg, D.S. | | 登録日 | 2017-06-13 | | 公開日 | 2018-02-21 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.4 Å) | | 主引用文献 | Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2.
Nat. Struct. Mol. Biol., 25, 2018
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6XPF
 | | Cryo-EM structure of human ZnT8 WT, in the absence of zinc, determined in heterogeneous conformations- one subunit in an inward-facing and the other in an outward-facing conformation | | 分子名称: | ZINC ION, Zinc transporter 8 | | 著者 | Bai, X.C, Xue, J, Jiang, Y.X. | | 登録日 | 2020-07-08 | | 公開日 | 2020-08-05 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (5.9 Å) | | 主引用文献 | Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations.
Elife, 9, 2020
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1W2Y
 | | The crystal structure of a complex of Campylobacter jejuni dUTPase with substrate analogue dUpNHp | | 分子名称: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-DIPHOSPHATE, DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDE HYDROLASE, MAGNESIUM ION | | 著者 | Moroz, O.V, Harkiolaki, M, Galperin, M.Y, Vagin, A.A, Gonzalez-Pacanowska, D, Wilson, K.S. | | 登録日 | 2004-07-09 | | 公開日 | 2004-09-16 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | The Crystal Structure of a Complex of Campylobacter Jejuni Dutpase with Substrate Analogue Sheds Light on the Mechanism and Suggests the "Basic Module" for Dimeric D(C/U)Tpases
J.Mol.Biol., 342, 2004
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1W6N
 | | X-RAY CRYSTAL STRUCTURE OF C2S HUMAN GALECTIN-1 | | 分子名称: | BETA-MERCAPTOETHANOL, GALECTIN-1, SULFATE ION | | 著者 | Lopez-Lucendo, M.I.F, Solis, D, Kaltner, H, Gabius, H.J, Romero, A. | | 登録日 | 2004-08-19 | | 公開日 | 2004-10-20 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Growth-Regulatory Human Galectin-1: Crystallographic Characterisation of the Structural Changes Induced by Single-Site Mutations and Their Impact on the Thermodynamics of Ligand Binding
J.Mol.Biol., 343, 2004
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6R7R
 | | Crystal structure of the glutamate transporter homologue GltTk in complex with D-aspartate | | 分子名称: | D-ASPARTIC ACID, DECYL-BETA-D-MALTOPYRANOSIDE, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Arkhipova, V, Guskov, A, Slotboom, D.J. | | 登録日 | 2019-03-29 | | 公開日 | 2019-04-17 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Binding and transport of D-aspartate by the glutamate transporter homolog Glt Tk .
Elife, 8, 2019
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6XRF
 | | EagT6 Tse6 NT complex | | 分子名称: | Effector EagT6, PAAR motif family protein | | 著者 | Sachar, K, Ahmad, S, Whitney, J.C, Prehna, G. | | 登録日 | 2020-07-12 | | 公開日 | 2020-12-30 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | | 主引用文献 | Structural basis for effector transmembrane domain recognition by type VI secretion system chaperones.
Elife, 9, 2020
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1VZK
 | | A Thiophene Based Diamidine Forms a "Super" AT Binding Minor Groove Agent | | 分子名称: | 2-(5-{4-[AMINO(IMINO)METHYL]PHENYL}-2-THIENYL)-1H-BENZIMIDAZOLE-6- CARBOXIMIDAMIDE DIHYDROCHLORIDE, 5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP *CP*G)-3', MAGNESIUM ION | | 著者 | Mallena, S, Lee, M.P.H, Bailly, C, Neidle, S, Kumar, A, Boykin, D.W, Wilson, W.D. | | 登録日 | 2004-05-20 | | 公開日 | 2004-10-25 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | Thiophene-Based Diamidine Forms a "Super" at Binding Minor Groove Agent
J.Am.Chem.Soc., 142, 2004
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1W22
 | | Crystal structure of inhibited human HDAC8 | | 分子名称: | HISTONE DEACETYLASE 8, N-HYDROXY-4-(METHYL{[5-(2-PYRIDINYL)-2-THIENYL]SULFONYL}AMINO)BENZAMIDE, POTASSIUM ION, ... | | 著者 | Vannini, A, Volpari, C, Caroli Casavola, E, Di Marco, S. | | 登録日 | 2004-06-25 | | 公開日 | 2004-09-24 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal Structure of a Eukaryotic Zn-Dependent Histone Deacetylase,Human Hdac8,Complexed with a Hydroxamic Acid Inhibitor
Proc.Natl.Acad.Sci.USA, 101, 2004
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5W64
 | | RNA Polymerase I Initial Transcribing Complex State 1 | | 分子名称: | DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... | | 著者 | Han, Y, He, Y. | | 登録日 | 2017-06-16 | | 公開日 | 2017-07-26 | | 最終更新日 | 2019-11-27 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structural mechanism of ATP-independent transcription initiation by RNA polymerase I.
Elife, 6, 2017
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