PDB: 4068 件ウェブページステータス検索Chemie searchBIRD

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1C2F	RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES 分子名称: BIS(5-AMIDINO-2-BENZIMIDAZOLYL)METHANE KETONE HYDRATE, CALCIUM ION, DIMETHYL SULFOXIDE, ... 著者 Katz, B.A, Luong, C. 登録日 1999-07-21 公開日 2000-07-26 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Design of potent selective zinc-mediated serine protease inhibitors. Nature, 391, 1998
1BMA	BENZYL METHYL AMINIMIDE INHIBITOR COMPLEXED TO PORCINE PANCREATIC ELASTASE 分子名称: (1R)-1-benzyl-1-methyl-1-(2-{[4-(1-methylethyl)phenyl]amino}-2-oxoethyl)-2-{(2S)-4-methyl-2-[(trifluoroacetyl)amino]pentanoyl}diazanium, CALCIUM ION, Chymotrypsin-like elastase family member 1, ... 著者 Peisach, E, Casebier, D, Gallion, S.L, Furth, P, Petsko, G.A, Hogan Jr, J.C, Ringe, D. 登録日 1995-05-01 公開日 1995-12-07 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Interaction of a peptidomimetic aminimide inhibitor with elastase. Science, 269, 1995
1NC6	Potent, small molecule inhibitors of human mast cell tryptase. Anti-asthmatic action of a dipeptide-based transition state analogue containing benzothiazole ketone 分子名称: (2S,4R)-1-ACETYL-N-[(1S)-4-[(AMINOIMINOMETHYL)AMINO]-1-(2-BENZOTHIAZOLYLCARBONYL)BUTYL]-4-HYDROXY-2-PYRROLIDINECARBOXAMIDE, CALCIUM ION, SULFATE ION, ... 著者 Costanzo, M.J, Yabut, S.C, Almond Jr, H.R, Andrade-Gordon, P, Corcoran, T.W, de Garavilla, L, Kauffman, J.A, Abraham, W.M, Recacha, R, Chattopadhyay, D, Maryanoff, B.E. 登録日 2002-12-04 公開日 2003-09-23 最終更新日 2017-10-11 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Potent, Small-Molecule Inhibitors of Human Mast Cell Tryptase. Antiasthmatic Action of a Dipeptide-Based Transition-State Analogue Containing a Benzothiazole Ketone. J.Med.Chem., 46, 2003
1LO6	Human Kallikrein 6 (hK6) active form with benzamidine inhibitor at 1.56 A resolution 分子名称: BENZAMIDINE, Kallikrein 6, MAGNESIUM ION 著者 Bernett, M.J, Blaber, S.I, Scarisbrick, I.A, Dhanarajan, P, Thompson, S.M, Blaber, M. 登録日 2002-05-06 公開日 2002-05-15 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Crystal structure and biochemical characterization of human kallikrein 6 reveals a trypsin-like kallikrein is expressed in the central nervous system To be Published
2BD8	Porcine pancreatic elastase complexed with beta-casomorphin-7 and Arg-Phe at pH 5.0 (50 min soak) and immersed in pH 9 buffer for 30 seconds 分子名称: CALCIUM ION, Chymotrypsin-like elastase family member 1, SULFATE ION, ... 著者 Liu, B, Schofield, C.J, Wilmouth, R.C. 登録日 2005-10-20 公開日 2006-05-30 最終更新日 2024-09-25 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural analyses on intermediates in serine protease catalysis J.Biol.Chem., 281, 2006
2BD5	Porcine pancreatic elastase complexed with beta-casomorphin-7 and Lys-Ser at pH 5 and immersed in pH 9 buffer for 30 seconds 分子名称: CALCIUM ION, Chymotrypsin-like elastase family member 1, SULFATE ION, ... 著者 Liu, B, Schofield, C.J, Wilmouth, R.C. 登録日 2005-10-20 公開日 2006-05-30 最終更新日 2024-09-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural analyses on intermediates in serine protease catalysis J.Biol.Chem., 281, 2006
2BD7	Porcine pancreatic elastase complexed with beta-casomorphin-7 and Arg-Phe at pH 5.0 (50 min soak) 分子名称: CALCIUM ION, Chymotrypsin-like elastase family member 1, SULFATE ION, ... 著者 Liu, B, Schofield, C.J, Wilmouth, R.C. 登録日 2005-10-20 公開日 2006-05-30 最終更新日 2024-09-25 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural analyses on intermediates in serine protease catalysis J.Biol.Chem., 281, 2006
2BD3	Porcine pancreatic elastase complexed with beta-casomorphin-7 and Lys-Ala-NH2 at pH 5.0 分子名称: CALCIUM ION, Chymotrypsin-like elastase family member 1, SULFATE ION, ... 著者 Liu, B, Schofield, C.J, Wilmouth, R.C. 登録日 2005-10-20 公開日 2006-05-30 最終更新日 2024-09-25 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural analyses on intermediates in serine protease catalysis J.Biol.Chem., 281, 2006
2BD4	Porcine pancreatic elastase complexed with beta-casomorphin-7 and Lys-Ser at pH 5.0 分子名称: CALCIUM ION, Chymotrypsin-like elastase family member 1, SULFATE ION, ... 著者 Liu, B, Schofield, C.J, Wilmouth, R.C. 登録日 2005-10-20 公開日 2006-05-30 最終更新日 2024-09-25 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural analyses on intermediates in serine protease catalysis J.Biol.Chem., 281, 2006
2BB4	Porcine pancreatic elastase complexed with beta-casomorphin-7 and Asp-Phe at pH 5.0 分子名称: CALCIUM ION, Chymotrypsin-like elastase family member 1, SULFATE ION, ... 著者 Liu, B, Schofield, C.J, Wilmouth, R.C. 登録日 2005-10-17 公開日 2006-05-30 最終更新日 2024-09-25 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural analyses on intermediates in serine protease catalysis J.Biol.Chem., 281, 2006
2BDA	Porcine pancreatic elastase complexed with N-acetyl-NPI and Ala-Ala at pH 5.0 分子名称: CALCIUM ION, Chymotrypsin-like elastase family member 1, NPI, ... 著者 Liu, B, Schofield, C.J, Wilmouth, R.C. 登録日 2005-10-20 公開日 2006-05-30 最終更新日 2024-09-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural analyses on intermediates in serine protease catalysis J.Biol.Chem., 281, 2006
2BD2	Porcine pancreatic elastase complexed with beta-casomorphin-7 and Arg-Phe at pH 5.0 分子名称: CALCIUM ION, Chymotrypsin-like elastase family member 1, SULFATE ION, ... 著者 Liu, B, Schofield, C.J, Wilmouth, R.C. 登録日 2005-10-20 公開日 2006-05-30 最終更新日 2024-09-25 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural analyses on intermediates in serine protease catalysis J.Biol.Chem., 281, 2006
1DWE	Crystallographic analysis at 3.0-Angstroms resolution of the binding to human thrombin of four active site-directed inhibitors 分子名称: ALPHA-THROMBIN heavy chain, ALPHA-THROMBIN light chain, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... 著者 Banner, D.W, Hadvary, P. 登録日 1992-08-19 公開日 1994-01-31 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. J.Biol.Chem., 266, 1991
2XTY	Structure of QnrB1 (R167E-Trypsin Treated), a plasmid-mediated fluoroquinolone resistance protein 分子名称: QNRB1 著者 Vetting, M.W, Hegde, S.S, Park, C.H, Jacoby, G.A, Hooper, D.C, Blanchard, J.S. 登録日 2010-10-13 公開日 2010-10-27 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure of Qnrb1, a Plasmid-Mediated Fluoroquinolone Resistance Factor. J.Biol.Chem., 286, 2011
2XTX	Structure of QnrB1 (M102R-Trypsin Treated), a plasmid-mediated fluoroquinolone resistance protein 分子名称: QNRB1, SULFATE ION 著者 Vetting, M.W, Hegde, S.S, Park, C.H, Jacoby, G.A, Hooper, D.C, Blanchard, J.S. 登録日 2010-10-12 公開日 2010-10-20 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure of Qnrb1, a Plasmid-Mediated Fluoroquinolone Resistance Factor. J.Biol.Chem., 286, 2011
1NN6	Human Pro-Chymase 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chymase 著者 Reiling, K.K, Krucinski, J, Miercke, L.J.W, Raymond, W.W, Caughey, G.H, Stroud, R.M. 登録日 2003-01-12 公開日 2003-03-04 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structure of human pro-chymase: a model for the activating transition of granule-associated proteases. Biochemistry, 42, 2003
5KUC	Crystal structure of trypsin activated Cry6Aa 分子名称: Pesticidal crystal protein Cry6Aa 著者 Kelker, M.S, Xu, X, Lee, M, Chan, M, Hung, S, Dementiev, K, Hey, T, Chikwana, V.M, Narva, K.E. 登録日 2016-07-13 公開日 2016-08-03 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The pesticidal Cry6Aa toxin from Bacillus thuringiensis is structurally similar to HlyE-family alpha pore-forming toxins. Bmc Biol., 14, 2016
1CO7	R117H mutant rat anionic trypsin complexed with bovine pancreatic trypsin inhibitor (BPTI) 分子名称: BOVINE PANCREATIC TRYPSIN INHIBITOR, CALCIUM ION, TRYPSIN II 著者 Stamper, G.F, Ringe, D, Hedstrom, L. 登録日 1999-06-07 公開日 2003-01-07 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献
1VTP	VACUOLAR TARGETING PEPTIDE FROM NA-PROPI 分子名称: VACUOLAR TARGETING PEPTIDE 著者 Nielsen, K.J, Hill, J.M, Anderson, M.A, Craik, D.J. 登録日 1995-11-14 公開日 1996-03-08 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Synthesis and structure determination by NMR of a putative vacuolar targeting peptide and model of a proteinase inhibitor from Nicotiana alata. Biochemistry, 35, 1996
1SFI	High resolution structure of a potent, cyclic protease inhibitor from sunflower seeds 分子名称: CALCIUM ION, SULFATE ION, TRYPSIN, ... 著者 Luckett, S, Garcia, R.S, Barker, J.J, Konarev, A.V, Shewry, P, Clarke, A.R, Brady, R.L. 登録日 1998-12-16 公開日 1999-07-09 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 High-resolution structure of a potent, cyclic proteinase inhibitor from sunflower seeds. J.Mol.Biol., 290, 1999
1TX8	Bovine Trypsin complexed with AMSO 分子名称: 4-(METHYLSULFONYL)BENZENECARBOXIMIDAMIDE, CALCIUM ION, Trypsinogen 著者 Mesecar, A.D. 登録日 2004-07-02 公開日 2005-10-18 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Design, synthesis, and evaluation of oxyanion-hole selective inhibitor substituents for the S1 subsite of factor Xa Bioorg.Med.Chem.Lett., 14, 2004
1ETT	REFINED 2.3 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF BOVINE THROMBIN COMPLEXES FORMED WITH THE BENZAMIDINE AND ARGININE-BASED THROMBIN INHIBITORS NAPAP, 4-TAPAP AND MQPA: A STARTING POINT FOR IMPROVING ANTITHROMBOTICS 分子名称: 4-[(2S)-2-{[(4-methylphenyl)sulfonyl]amino}-3-oxo-3-(piperidin-1-yl)propyl]benzene-1-carboximidamide, EPSILON-THROMBIN 著者 Bode, W, Brandstetter, H. 登録日 1992-07-06 公開日 1994-01-31 最終更新日 2018-09-12 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics. J.Mol.Biol., 226, 1992
1ETR	REFINED 2.3 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF BOVINE THROMBIN COMPLEXES FORMED WITH THE BENZAMIDINE AND ARGININE-BASED THROMBIN INHIBITORS NAPAP, 4-TAPAP AND MQPA: A STARTING POINT FOR IMPROVING ANTITHROMBOTICS 分子名称: EPSILON-THROMBIN, amino{[(4S)-5-[(2R,4R)-2-carboxy-4-methylpiperidin-1-yl]-4-({[(3R)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonyl}amino)-5-oxopentyl]amino}methaniminium 著者 Bode, W, Brandstetter, H. 登録日 1992-07-06 公開日 1994-01-31 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics. J.Mol.Biol., 226, 1992
1BT7	THE SOLUTION NMR STRUCTURE OF THE N-TERMINAL PROTEASE DOMAIN OF THE HEPATITIS C VIRUS (HCV) NS3-PROTEIN, FROM BK STRAIN, 20 STRUCTURES 分子名称: NS3 SERINE PROTEASE, ZINC ION 著者 Barbato, G, Cicero, D.O, Nardi, M.C, Steinkuhler, C, Cortese, R, De Francesco, R, Bazzo, R. 登録日 1998-09-01 公開日 1999-06-22 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism. J.Mol.Biol., 289, 1999
1GI2	A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE 分子名称: 2-(2-HYDROXY-PHENYL)-3H-BENZOIMIDAZOLE-5-CARBOXAMIDINE, BETA-TRYPSIN, CALCIUM ION, ... 著者 Katz, B.A, Elrod, K, Luong, C, Rice, M, Mackman, R.L, Sprengeler, P.A, Spencer, J, Hatayte, J, Janc, J, Link, J, Litvak, J, Rai, R, Rice, K, Sideris, S, Verner, E, Young, W. 登録日 2001-01-22 公開日 2002-01-22 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site. J.Mol.Biol., 307, 2001

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