1ETT

REFINED 2.3 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF BOVINE THROMBIN COMPLEXES FORMED WITH THE BENZAMIDINE AND ARGININE-BASED THROMBIN INHIBITORS NAPAP, 4-TAPAP AND MQPA: A STARTING POINT FOR IMPROVING ANTITHROMBOTICS

Summary for 1ETT

Entry DOI	10.2210/pdb1ett/pdb
Related	1ETR 1ETS
Descriptor	EPSILON-THROMBIN, 4-[(2S)-2-{[(4-methylphenyl)sulfonyl]amino}-3-oxo-3-(piperidin-1-yl)propyl]benzene-1-carboximidamide, ... (4 entities in total)
Functional Keywords	serine proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Bos taurus (cow) More
Total number of polymer chains	2
Total formula weight	35936.21
Authors	Bode, W.,Brandstetter, H. (deposition date: 1992-07-06, release date: 1994-01-31, Last modification date: 2018-09-12)
Primary citation	Brandstetter, H.,Turk, D.,Hoeffken, H.W.,Grosse, D.,Sturzebecher, J.,Martin, P.D.,Edwards, B.F.,Bode, W. Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics. J.Mol.Biol., 226:1085-1099, 1992 Cited by PubMed: 1518046 DOI: 10.1016/0022-2836(92)91054-S PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation