1ETT
REFINED 2.3 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF BOVINE THROMBIN COMPLEXES FORMED WITH THE BENZAMIDINE AND ARGININE-BASED THROMBIN INHIBITORS NAPAP, 4-TAPAP AND MQPA: A STARTING POINT FOR IMPROVING ANTITHROMBOTICS
Summary for 1ETT
Entry DOI | 10.2210/pdb1ett/pdb |
Related | 1ETR 1ETS |
Descriptor | EPSILON-THROMBIN, 4-[(2S)-2-{[(4-methylphenyl)sulfonyl]amino}-3-oxo-3-(piperidin-1-yl)propyl]benzene-1-carboximidamide, ... (4 entities in total) |
Functional Keywords | serine proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Bos taurus (cow) More |
Total number of polymer chains | 2 |
Total formula weight | 35936.21 |
Authors | Bode, W.,Brandstetter, H. (deposition date: 1992-07-06, release date: 1994-01-31, Last modification date: 2018-09-12) |
Primary citation | Brandstetter, H.,Turk, D.,Hoeffken, H.W.,Grosse, D.,Sturzebecher, J.,Martin, P.D.,Edwards, B.F.,Bode, W. Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics. J.Mol.Biol., 226:1085-1099, 1992 Cited by PubMed: 1518046DOI: 10.1016/0022-2836(92)91054-S PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report