PDB: 1847 件ウェブページステータス検索Chemie searchBIRD

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4MDD	Crystal Structure of the Glucocorticoid Receptor Bound to a Non-steroidal Antagonist Reveals Repositioning and Partial Disordering of Activation Function Helix 12 分子名称: Glucocorticoid receptor, N-[2-{[benzyl(methyl)amino]methyl}-3-(4-fluoro-2-methoxyphenyl)-5-(propan-2-yl)-1H-indol-7-yl]methanesulfonamide, Nuclear receptor corepressor 1 著者 Coghlan, M.J, Luz, J.G. 登録日 2013-08-22 公開日 2014-12-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structure of the Glucocorticoid Receptor Bound to a Non-steroidal Antagonist Reveals Repositioning and Partial Disordering of Activation Function Helix 12 To be Published
4M8H	CRYSTAL STRUCTURE OF HUMAN RETINOID X RECEPTOR ALPHA-LIGAND BINDING DOMAIN COMPLEX WITH (R)4-METHYL 9cUAB30 AND COACTIVATOR PEPTIDE GRIP-1 分子名称: (2E,6Z,8E)-3,7-dimethyl-8-[(4R)-4-methyl-3,4-dihydronaphthalen-1(2H)-ylidene]octa-2,6-dienoic acid, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha 著者 Xia, G, Smith, C.D, Muccio, D.D. 登録日 2013-08-13 公開日 2014-01-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Methyl-substituted conformationally constrained rexinoid agonists for the retinoid X receptors demonstrate improved efficacy for cancer therapy and prevention. Bioorg.Med.Chem., 22, 2014
4M8E	CRYSTAL STRUCTURE OF HUMAN RETINOID X RECEPTOR ALPHA-LIGAND BINDING DOMAIN COMPLEX WITH (S) 4-Methyl 9cUAB30 COACTIVATOR PEPTIDE GRIP-1 分子名称: (3E,6Z,8E)-3,7-dimethyl-8-[(4S)-4-methyl-3,4-dihydronaphthalen-1(2H)-ylidene]octa-3,6-dienoic acid, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha 著者 Xia, G, Smith, C.D, Muccio, D.D. 登録日 2013-08-13 公開日 2014-01-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Methyl-substituted conformationally constrained rexinoid agonists for the retinoid X receptors demonstrate improved efficacy for cancer therapy and prevention. Bioorg.Med.Chem., 22, 2014
4LSJ	Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Bound to a Dibenzoxapine Sulfonamide 分子名称: D30 peptide, Glucocorticoid receptor, N-{3-[(1Z)-1-(10-methoxydibenzo[b,e]oxepin-11(6H)-ylidene)propyl]phenyl}methanesulfonamide 著者 Carson, M, Luz, J.G, Clawson, D, Coghlan, M. 登録日 2013-07-22 公開日 2014-01-29 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Glucocorticoid receptor modulators informed by crystallography lead to a new rationale for receptor selectivity, function, and implications for structure-based design. J.Med.Chem., 57, 2014
4LOG	The crystal structure of the orphan nuclear receptor PNR ligand binding domain fused with MBP 分子名称: Maltose ABC transporter periplasmic protein and NR2E3 protein chimeric construct 著者 Tan, M.E, Zhou, X.E, Soon, F.-F, Li, X, Li, J, Yong, E.-L, Melcher, K, Xu, H.E. 登録日 2013-07-12 公開日 2013-10-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 The Crystal Structure of the Orphan Nuclear Receptor NR2E3/PNR Ligand Binding Domain Reveals a Dimeric Auto-Repressed Conformation. Plos One, 8, 2013
4LNX	Crystal structure of TR-alpha bound to T4 in a second site 分子名称: 3,5,3',5'-TETRAIODO-L-THYRONINE, 3,5,3'TRIIODOTHYRONINE, Thyroid hormone receptor alpha 著者 Puhl, A.C, Aparicio, R, Polikarpov, I. 登録日 2013-07-12 公開日 2014-03-19 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Identification of a new hormone-binding site on the surface of thyroid hormone receptor. Mol.Endocrinol., 28, 2014
4LNW	Crystal structure of TR-alpha bound to T3 in a second site 分子名称: 3,5,3'TRIIODOTHYRONINE, Thyroid hormone receptor alpha 著者 Puhl, A.C, Aparicio, R, Polikarpov, I. 登録日 2013-07-12 公開日 2014-03-19 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Identification of a new hormone-binding site on the surface of thyroid hormone receptor. Mol.Endocrinol., 28, 2014
4LBD	LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO THE SYNTHETIC AGONIST BMS961 分子名称: 3-FLUORO-4-[2-HYDROXY-2-(5,5,8,8-TETRAMETHYL-5,6,7,8,-TETRAHYDRO-NAPHTALEN-2-YL)-ACETYLAMINO]-BENZOIC ACID, RETINOIC ACID RECEPTOR GAMMA 著者 Klaholz, B.P, Renaud, J.-P, Mitschler, A, Moras, D, Structural Proteomics in Europe (SPINE) 登録日 1998-02-04 公開日 1999-03-02 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Conformational adaptation of agonists to the human nuclear receptor RAR gamma. Nat.Struct.Biol., 5, 1998
4L98	Crystal structure of the complex of F360L PPARgamma mutant with the ligand LT175 分子名称: (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid, Peroxisome proliferator-activated receptor gamma 著者 Pochetti, G, Montanari, R, Consalvi, V, Chiaraluce, R, Pasquo, A, Capelli, D, Loiodice, F, Laghezza, A, Lori, C. 登録日 2013-06-18 公開日 2014-06-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Structural basis of the transactivation deficiency of the human PPAR gamma F360L mutant associated with familial partial lipodystrophy. Acta Crystallogr.,Sect.D, 70, 2014
4L96	Structure of the complex between the F360L PPARgamma mutant and the ligand LT175 (space group I222) 分子名称: (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid, Peroxisome proliferator-activated receptor gamma 著者 Pochetti, G, Montanari, R, Capelli, D, Chiaraluce, R, Consalvi, V, Pasquo, A, Lori, C, Laghezza, A, Loiodice, F. 登録日 2013-06-18 公開日 2014-06-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Structural basis of the transactivation deficiency of the human PPAR gamma F360L mutant associated with familial partial lipodystrophy. Acta Crystallogr.,Sect.D, 70, 2014
4KZM	Crystal Structure of TR3 LBD S553A Mutant 分子名称: GLYCEROL, Nuclear receptor subfamily 4 group A member 1 著者 Li, F, Zhang, Q, Li, A, Tian, X, Cai, Q, Wang, W, Wang, Y, Chen, H, Xing, Y, Wu, Q, Lin, T. 登録日 2013-05-30 公開日 2013-12-18 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat.Chem.Biol., 10, 2014
4KZJ	Crystal Structure of TR3 LBD L449W Mutant 分子名称: GLYCEROL, Nuclear receptor subfamily 4 group A member 1 著者 Li, F, Zhang, Q, Li, A, Tian, X, Cai, Q, Wang, W, Wang, Y, Chen, H, Xing, Y, Wu, Q, Lin, T. 登録日 2013-05-30 公開日 2013-12-18 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat.Chem.Biol., 10, 2014
4KZI	Crystal Structure of TR3 LBD in complex with DPDO 分子名称: 1-(3,5-dimethoxyphenyl)decan-1-one, GLYCEROL, Nuclear receptor subfamily 4 group A member 1 著者 Li, F, Zhang, Q, Li, A, Tian, X, Cai, Q, Wang, W, Wang, Y, Chen, H, Xing, Y, Wu, Q, Lin, T. 登録日 2013-05-30 公開日 2013-12-18 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat.Chem.Biol., 10, 2014
4K7A	Crystal structure of the androgen receptor ligand binding domain in complex with minoxidil 分子名称: 5-ALPHA-DIHYDROTESTOSTERONE, 6-PIPERIDIN-1-YLPYRIMIDINE-2,4-DIAMINE 3-OXIDE, Androgen receptor 著者 Liu, J.S, Hsu, C.L, Wu, W.G. 登録日 2013-04-16 公開日 2014-04-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 Crystal structure of the androgen receptor ligand binding domain in complex with minoxidil To be Published
4K6I	Crystal structure of human retinoid X receptor alpha-ligand binding domain complex with Targretin and the coactivator peptide GRIP-1 分子名称: 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha 著者 Xia, G, Smith, C.D, Muccio, D.D. 登録日 2013-04-15 公開日 2013-11-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Defining the Communication between Agonist and Coactivator Binding in the Retinoid X Receptor alpha Ligand Binding Domain. J.Biol.Chem., 289, 2014
4K4J	Crystal structure of human Retinoid X Receptor alpha-ligand binding domain complex with 9cUAB30 and the coactivator peptide GRIP-1 分子名称: (2E,4E,6Z,8E)-8-(3,4-dihydronaphthalen-1(2H)-ylidene)-3,7-dimethylocta-2,4,6-trienoic acid, Nuclear receptor coactivator 2 peptide, Retinoic acid receptor RXR-alpha 著者 Xia, G, Smith, C.D, Muccio, D.D. 登録日 2013-04-12 公開日 2013-11-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Defining the Communication between Agonist and Coactivator Binding in the Retinoid X Receptor alpha Ligand Binding Domain. J.Biol.Chem., 289, 2014
4JYI	Crystal structure of RARbeta LBD in complex with selective partial agonist BMS641 [3-chloro-4-[(E)-2-(5,5-dimethyl-8-phenyl-5,6-dihydronaphthalen-2-yl)ethenyl]benzoic acid] 分子名称: 3-chloro-4-[(E)-2-(5,5-dimethyl-8-phenyl-5,6-dihydronaphthalen-2-yl)ethenyl]benzoic acid, CITRATE ANION, Nuclear receptor coactivator 1, ... 著者 Nadendla, E.K, Teyssier, C, Germain, P, Delfosse, V, Bourguet, W. 登録日 2013-03-29 公開日 2014-03-19 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor beta (RAR beta , NR1B2) Selective Agonist. Plos One, 10, 2015
4JYH	Crystal structure of RARbeta LBD in complex with selective agonist BMS948 [4-{[(8-phenylnaphthalen-2-yl)carbonyl]amino}benzoic acid] 分子名称: 4-{[(8-phenylnaphthalen-2-yl)carbonyl]amino}benzoic acid, CITRATE ANION, Nuclear receptor coactivator 1, ... 著者 Nadendla, E.K, Teyssier, C, Germain, P, Delfosse, V, Bourguet, W. 登録日 2013-03-29 公開日 2014-03-19 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor beta (RAR beta , NR1B2) Selective Agonist. Plos One, 10, 2015
4JYG	Crystal structure of RARbeta LBD in complex with agonist BMS411 [4-{[(5,5-dimethyl-8-phenyl-5,6-dihydronaphthalen-2-yl)carbonyl]amino}benzoic acid] 分子名称: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 4-{[(5,5-dimethyl-8-phenyl-5,6-dihydronaphthalen-2-yl)carbonyl]amino}benzoic acid, CITRATE ANION, ... 著者 Nadendla, E.K, Teyssier, C, Germain, P, Delfosse, V, Bourguet, W. 登録日 2013-03-29 公開日 2014-03-19 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor beta (RAR beta , NR1B2) Selective Agonist. Plos One, 10, 2015
4JL4	Crystal structure of the complex between PPARgamma LBD and the ligand LJ570 [(2S)-3-(biphenyl-4-yl)-2-(biphenyl-4-yloxy)propanoic acid] 分子名称: (2S)-3-(biphenyl-4-yl)-2-(biphenyl-4-yloxy)propanoic acid, Peroxisome proliferator-activated receptor gamma 著者 Pochetti, G, Montanari, R, Capelli, D. 登録日 2013-03-12 公開日 2014-03-12 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Identification of the First PPAR alpha / gamma Dual Agonist Able To Bind to Canonical and Alternative Sites of PPAR gamma and To Inhibit Its Cdk5-Mediated Phosphorylation. J.Med.Chem., 61, 2018
4JGV	Crystal Structure of Human Nur77 Ligand-binding Domain in Complex with THPN 分子名称: 1-(3,4,5-trihydroxyphenyl)nonan-1-one, GLYCEROL, Nuclear receptor subfamily 4 group A member 1 著者 Zhang, Q, Li, F, Li, A, Tian, X, Wan, W, Wan, Y, Chen, H, Xing, Y, Wu, Q, Lin, T. 登録日 2013-03-04 公開日 2013-12-18 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (3.01 Å) 主引用文献 Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat.Chem.Biol., 10, 2014
4JAZ	Crystal structure of the complex between PPARgamma LBD and trans-resveratrol 分子名称: Peroxisome proliferator-activated receptor gamma, RESVERATROL 著者 Pochetti, G, Capelli, D, Montanari, R, Calleri, E, Moaddel, R, Temporini, C. 登録日 2013-02-19 公開日 2014-02-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Resveratrol and Its Metabolites Bind to PPARs. Chembiochem, 15, 2014
4J5X	Crystal Structure of the SR12813-bound PXR/RXRalpha LBD Heterotetramer Complex 分子名称: Nuclear receptor subfamily 1 group I member 2, Nuclear receptor coactivator 1, Retinoic acid receptor RXR-alpha, ... 著者 Wallace, B.D, Betts, L, Redinbo, M.R. 登録日 2013-02-10 公開日 2013-08-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural and Functional Analysis of the Human Nuclear Xenobiotic Receptor PXR in Complex with RXRalpha. J.Mol.Biol., 425, 2013
4J5W	Crystal Structure of the apo-PXR/RXRalpha LBD Heterotetramer Complex 分子名称: MAGNESIUM ION, Nuclear receptor subfamily 1 group I member 2, Nuclear receptor coactivator 1, ... 著者 Wallace, B.D, Betts, L, Redinbo, M.R. 登録日 2013-02-10 公開日 2013-08-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural and Functional Analysis of the Human Nuclear Xenobiotic Receptor PXR in Complex with RXRalpha. J.Mol.Biol., 425, 2013
4J26	Estrogen Receptor in complex with proline-flanked LXXLL peptides 分子名称: 12-mer Peptide, ESTRADIOL, Estrogen receptor beta 著者 Fuchs, S, Nguyen, H.D, Phan, T, Burton, M, Nieto, L, de Vries-van Leeuwen, I, Schmidt, A, Goodarzifard, M, Agten, S, Rose, R, Ottmann, C, Milroy, L.G, Brunsveld, L. 登録日 2013-02-04 公開日 2013-03-13 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Proline primed helix length as a modulator of the nuclear receptor-coactivator interaction J.Am.Chem.Soc., 135, 2013

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