4JL4

Crystal structure of the complex between PPARgamma LBD and the ligand LJ570 [(2S)-3-(biphenyl-4-yl)-2-(biphenyl-4-yloxy)propanoic acid]

Summary for 4JL4

DescriptorPeroxisome proliferator-activated receptor gamma, (2S)-3-(biphenyl-4-yl)-2-(biphenyl-4-yloxy)propanoic acid (3 entities in total)
Functional Keywordsbundle of alpha-helices, small four-strnded beta-sheet, transcription factor, rxr, transcription-agonist complex, transcription/agonist
Biological sourceHomo sapiens (human)
Cellular locationNucleus P37231
Total number of polymer chains2
Total molecular weight65782.11
Authors
Pochetti, G.,Montanari, R.,Capelli, D. (deposition date: 2013-03-12, release date: 2014-03-12)
Primary citation
Pochetti, G.,Montanari, R.,Capelli, D.
Crystal structure of the complex between PPARgamma LBD and the dual agonist LJ570
To be Published,
Experimental method
X-RAY DIFFRACTION (2.5 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.282385.6%8.7%10.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report