PDB: 37224 件ウェブページステータス検索Chemie searchBIRD

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2FS4	Ketopiperazine-Based Renin Inhibitors: Optimization of the C ring 分子名称: (6R)-6-({[1-(3-HYDROXYPROPYL)-1,7-DIHYDROQUINOLIN-7-YL]OXY}METHYL)-1-(4-{3-[(2-METHOXYBENZYL)OXY]PROPOXY}PHENYL)PIPERAZIN-2-ONE, Renin 著者 Holsworth, D.D, Cai, C, Cheng, X.-M, Cody, W.L, Downing, D.M, Erasga, N, Lee, C, Powell, N.A, Edmunds, J.J, Stier, M, Jalaie, M, Zhang, E, McConnell, P, Ryan, M.J, Bryant, J, Li, T, Kasani, A, Hall, E, Subedi, R, Rahim, M, Maiti, S. 登録日 2006-01-20 公開日 2006-06-13 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Ketopiperazine-Based Renin Inhibitors: Optimization of the "C" Ring BIOORG.MED.CHEM.LETT., 16, 2006
2G4B	Structure of U2AF65 variant with polyuridine tract 分子名称: 1,4-DIETHYLENE DIOXIDE, 5'-R(P*UP*UP*UP*UP*UP*UP*U)-3', Splicing factor U2AF 65 kDa subunit 著者 Sickmier, E.A, Kielkopf, C.L. 登録日 2006-02-21 公開日 2006-07-25 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis of polypyrimidine tract recognition by the essential splicing factor U2AF65. Mol.Cell, 23, 2006
2FVD	Cyclin Dependent Kinase 2 (CDK2) with diaminopyrimidine inhibitor 分子名称: (4-AMINO-2-{[1-(METHYLSULFONYL)PIPERIDIN-4-YL]AMINO}PYRIMIDIN-5-YL)(2,3-DIFLUORO-6-METHOXYPHENYL)METHANONE, Cell division protein kinase 2 著者 Crowther, R.L, Lukacs, C.M, Kammlott, R.U. 登録日 2006-01-30 公開日 2006-10-10 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity. J.Med.Chem., 49, 2006
2FXD	X-ray crystal structure of HIV-1 protease IRM mutant complexed with atazanavir (BMS-232632) 分子名称: (3S,8S,9S,12S)-3,12-BIS(1,1-DIMETHYLETHYL)-8-HYDROXY-4,11-DIOXO-9-(PHENYLMETHYL)-6-[[4-(2-PYRIDINYL)PHENYL]METHYL]-2,5, 6,10,13-PENTAAZATETRADECANEDIOIC ACID DIMETHYL ESTER, ACETATE ION, ... 著者 Klei, H.E, Sheriff, S. 登録日 2006-02-04 公開日 2007-02-20 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 X-ray crystal structures of human immunodeficiency virus type 1 protease mutants complexed with atazanavir. J.Virol., 81, 2007
2GAO	Crystal Structure of Human SAR1a in Complex With GDP 分子名称: GTP-binding protein SAR1a, GUANOSINE-5'-DIPHOSPHATE, UNKNOWN ATOM OR ION 著者 Wang, J, Dimov, S, Tempel, W, Yaniw, D, Arrowsmith, C, Edwards, A, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) 登録日 2006-03-09 公開日 2006-03-21 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure of Human SAR1a in Complex With GDP To be Published
2G1S	Ketopiperazine-Based Renin Inhibitors: Optimization of the C Ring 分子名称: (2S)-6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2-(3,5-DIFLUOROPHENYL)-4-(3-METHOXYPROPYL)-2H-1,4-BENZOXAZIN-3(4H)-ONE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Renin 著者 Holsworth, D.D, Jalaiea, M, Zhanga, E, Mcconnella, P. 登録日 2006-02-14 公開日 2006-06-13 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Ketopiperazine-Based Renin Inhibitors: Optimization of the "C" Ring BIOORG.MED.CHEM.LETT., 16, 2006
8TUI	Crystal structure of Fab-Lirilumab bound to KIR2DL3 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Killer cell immunoglobulin-like receptor 2DL3, Lirilumab Fab Heavy Chain, ... 著者 Lorig-Roach, N, DuBois, R.M. 登録日 2023-08-16 公開日 2023-12-06 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Structural basis for the activity and specificity of the immune checkpoint inhibitor lirilumab. Sci Rep, 14, 2024
8TUC	Unphosphorylated CaMKK2 in complex with CC-8977 分子名称: (4M)-2-cyclopentyl-4-(7-ethoxyquinazolin-4-yl)benzoic acid, 1,2-ETHANEDIOL, Calcium/calmodulin-dependent protein kinase kinase 2, ... 著者 Bernard, S.M, Shanmugasundaram, V, D'Agostino, L. 登録日 2023-08-16 公開日 2023-12-13 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Identification of Small Molecule Inhibitors and Ligand Directed Degraders of Calcium/Calmodulin Dependent Protein Kinase Kinase 1 and 2 (CaMKK1/2). J.Med.Chem., 66, 2023
8U3N	Structure of P450Blt from Micromonospora sp. MW-13 分子名称: Cytochrome P450-SU1, POTASSIUM ION, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Hansen, M.H, Cryle, M.J, Zhao, Y. 登録日 2023-09-08 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural Insights into a Side Chain Cross-Linking Biarylitide P450 from RiPP Biosynthesis Acs Catalysis, 2024
8TWD	Structure of IraM-bound RssB 分子名称: ACETATE ION, Anti-adapter protein IraM, Regulator of RpoS 著者 Brugger, C, Deaconescu, A.M. 登録日 2023-08-20 公開日 2024-01-10 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 IraM remodels the RssB segmented helical linker to stabilize sigma s against degradation by ClpXP. J.Biol.Chem., 300, 2023
8U2M	Structure of P450Blt from Micromonospora sp. MW-13 in Complex with Biarylitide 分子名称: 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL, ACETATE ION, Cytochrome P450-SU1, ... 著者 Hansen, M.H, Cryle, M.J. 登録日 2023-09-06 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Structural Insights into a Side Chain Cross-Linking Biarylitide P450 from RiPP Biosynthesis Acs Catalysis, 2024
8TRM	Actin 1 from T. gondii in filaments bound to MgADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin, MAGNESIUM ION 著者 Hvorecny, K.L, Sladewski, T.E, Heaslip, A.T, Kollman, J.M. 登録日 2023-08-09 公開日 2024-03-06 実験手法 ELECTRON MICROSCOPY (2.5 Å) 主引用文献 Toxoplasma gondii actin filaments are tuned for rapid disassembly and turnover. Nat Commun, 15, 2024
8TRN	Actin 1 from T. gondii in filaments bound to MgADP and jasplakinolide 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin, Jasplakinolide, ... 著者 Hvorecny, K.L, Sladewski, T.E, Heaslip, A.T, Kollman, J.M. 登録日 2023-08-09 公開日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Toxoplasma gondii actin filaments are tuned for rapid disassembly and turnover. Nat Commun, 15, 2024
8U8J	Co-crystal structure of phosphorylated ERK2 in complex with ERK1/2 inhibitor #16 分子名称: (4M)-4-{(4R)-3-[(2S)-2-methylbutyl][1,2,4]triazolo[4,3-a]pyridin-7-yl}-N-(1-methyl-1H-pyrazol-5-yl)pyrimidin-2-amine, Mitogen-activated protein kinase 1 著者 Anderson, J.W, Vigers, G.P. 登録日 2023-09-18 公開日 2024-03-27 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2. Elife, 12, 2024
8U8K	Co-crystal structure of phosphorylated ERK2 in complex with ERK1/2 inhibitor #8 分子名称: (4M)-4-{(4S)-3-[(2-chloropyridin-3-yl)methyl][1,2,4]triazolo[4,3-a]pyridin-7-yl}-N-(oxan-4-yl)pyrimidin-2-amine, Mitogen-activated protein kinase 1 著者 Anderson, J.W, Vigers, G.P. 登録日 2023-09-18 公開日 2024-03-27 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2. Elife, 12, 2024
8U1S	A mechanistic understanding of protective influenza B neuraminidase mAbs at the airway interface 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Neuraminidase, mAb-393 heavy chain, ... 著者 Ferguson, J.A, Raghavan, S.S.R, Ward, A.B. 登録日 2023-09-02 公開日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.21 Å) 主引用文献 A mechanistic understanding of protective influenza B neuraminidase mAbs at the airway interface To Be Published
8U1C	A mechanistic understanding of protective influenza B neuraminidase mAbs at the airway interface 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Neuraminidase, mAb-400 heavy chain, ... 著者 Ferguson, J.A, Oeverdieck, S, Ward, A.B. 登録日 2023-08-31 公開日 2024-03-27 実験手法 ELECTRON MICROSCOPY (2.89 Å) 主引用文献 A mechanistic understanding of protective influenza B neuraminidase mAbs at the airway interface To Be Published
8U1Q	A mechanistic understanding of protective influenza B neuraminidase mAbs at the airway interface 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Neuraminidase, mAb-2D10 heavy chain, ... 著者 Ferguson, J.A, Oeverdieck, S, Ward, A.B. 登録日 2023-09-01 公開日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.36 Å) 主引用文献 A mechanistic understanding of protective influenza B neuraminidase mAbs at the airway interface To Be Published
8TS0	Crystal Structure of human ASGR1 CRD (Carbohydrate Recognition Domain) bound to 8M24 Fab 分子名称: 8M24 Fab Heavy chain, 8M24 Fab Light chain, Asialoglycoprotein receptor 1, ... 著者 Sampathkumar, P, Li, Y. 登録日 2023-08-10 公開日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Targeted protein degradation systems to enhance Wnt signaling. Elife, 13, 2024
8THO	Solution structure of the zinc finger repeat domain of BCL11A (ZnF456) 分子名称: B-cell lymphoma/leukemia 11A, ZINC ION 著者 Viennet, T, Yin, M, Orkin, S.H, Arthanari, H. 登録日 2023-07-17 公開日 2024-07-24 実験手法 SOLUTION NMR 主引用文献 Structural and dynamic investigation of DNA-binding by BCL11A reveals a specific role for ZnF6 To Be Published
8TGT	Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M68 protein 分子名称: 1,2-ETHANEDIOL, C4b-binding protein alpha chain, CALCIUM ION, ... 著者 Kolesinski, P, Ghosh, P. 登録日 2023-07-13 公開日 2024-07-17 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M68 protein To Be Published
8THX	Yeast actin A167E mutant wt-like 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin, MAGNESIUM ION 著者 Volkmann, N, Hanein, D. 登録日 2023-07-18 公開日 2024-07-31 実験手法 ELECTRON MICROSCOPY (3.98 Å) 主引用文献 yeast actin A167E mutant wt-like To Be Published
8THY	Yeast actin A167E mutant rabbit-like 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin, MAGNESIUM ION 著者 Volkmann, N, Hanein, D. 登録日 2023-07-18 公開日 2024-07-31 実験手法 ELECTRON MICROSCOPY (3.84 Å) 主引用文献 yeast actin A167E mutant rabbit-like To Be Published
8TLR	Crystal Structure of human HRAS G12C covalently bound to AMG 510 分子名称: AMG 510 (bound form), GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Morstein, J, Guiley, K.Z, Shokat, K.M. 登録日 2023-07-27 公開日 2024-07-31 最終更新日 2024-09-25 実験手法 X-RAY DIFFRACTION (1.70003951 Å) 主引用文献 Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket. Cell, 2024
8TI3	Yeast actin wild type 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin, MAGNESIUM ION 著者 Volkmann, N, Hanein, D. 登録日 2023-07-19 公開日 2024-07-31 実験手法 ELECTRON MICROSCOPY (4.43 Å) 主引用文献 yeast actin wild type To Be Published

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