8TUC

Unphosphorylated CaMKK2 in complex with CC-8977

Summary for 8TUC

Entry DOI	10.2210/pdb8tuc/pdb
Descriptor	Calcium/calmodulin-dependent protein kinase kinase 2, (4M)-2-cyclopentyl-4-(7-ethoxyquinazolin-4-yl)benzoic acid, SULFATE ION, ... (5 entities in total)
Functional Keywords	calcium/calmodulin dependent protein kinase kinase 2, camkk2, inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	33998.06
Authors	Bernard, S.M.,Shanmugasundaram, V.,D'Agostino, L. (deposition date: 2023-08-16, release date: 2023-12-13, Last modification date: 2023-12-27)
Primary citation	Chen, Y.,Whitefield, B.,Nevius, E.,Hill, M.,DelRosario, J.,Sinitsyna, N.,Shanmugasundaram, V.,Mukherjee, D.,Shi, L.,Mayne, C.G.,Rousseau, A.M.,Bernard, S.M.,Buenviaje, J.,Khambatta, G.,El Samin, M.,Wallace, M.,Nie, Z.,Sivakumar, P.,Hamann, L.G.,McDonnell, D.P.,D'Agostino, L.A. Identification of Small Molecule Inhibitors and Ligand Directed Degraders of Calcium/Calmodulin Dependent Protein Kinase Kinase 1 and 2 (CaMKK1/2). J.Med.Chem., 66:15750-15760, 2023 Cited by PubMed: 38009718 DOI: 10.1021/acs.jmedchem.3c01137 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation