8U8J

Co-crystal structure of phosphorylated ERK2 in complex with ERK1/2 inhibitor #16

Summary for 8U8J

• Entry DOI: 10.2210/pdb8u8j/pdb
• Related: 8U8K
• Descriptor: Mitogen-activated protein kinase 1, (4M)-4-{(4R)-3-[(2S)-2-methylbutyl][1,2,4]triazolo[4,3-a]pyridin-7-yl}-N-(1-methyl-1H-pyrazol-5-yl)pyrimidin-2-amine (3 entities in total)
• Functional Keywords: protein kinase, atp-competitive inhibitor, conformation selection, signaling protein, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 41496.46

Authors

Anderson, J.W.,Vigers, G.P. (deposition date: 2023-09-18, release date: 2024-03-27, Last modification date: 2024-04-10)

• Primary citation: Anderson, J.W.,Vaisar, D.,Jones, D.N.,Pegram, L.M.,Vigers, G.P.,Chen, H.,Moffat, J.G.,Ahn, N.G.; Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2.; Elife, 12:-, 2024; PubMed: 38537148; DOI: 10.7554/eLife.91507

Experimental method

X-RAY DIFFRACTION (2.1 Å)