8U8J
Co-crystal structure of phosphorylated ERK2 in complex with ERK1/2 inhibitor #16
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase 1 | polymer | 354 | 41134.0 | 1 | UniProt (P28482) Pfam (PF00069) | Homo sapiens (human) | MAP kinase 1,MAPK 1,ERT1,Extracellular signal-regulated kinase 2,ERK-2,MAP kinase isoform p42,p42-MAPK,Mitogen-activated protein kinase 2,MAP kinase 2,MAPK 2 |
| 2 | B (A) | (4M)-4-{(4R)-3-[(2S)-2-methylbutyl][1,2,4]triazolo[4,3-a]pyridin-7-yl}-N-(1-methyl-1H-pyrazol-5-yl)pyrimidin-2-amine | non-polymer | 362.4 | 1 | Chemie (WAL) PubChem (118209478) PubChem (118216704) PubChem (118216951) | |||
| 3 | C (A) | water | water | 18.0 | 231 | Chemie (HOH) |
Sequence modifications
A: 5 - 358 (UniProt: P28482)
| PDB | External Database | Details |
|---|---|---|
| Ser 5 | Ala 7 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41134.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 362.4 | |
| All* | Total formula weight | 41496.5 |
