8TLR

Crystal Structure of human HRAS G12C covalently bound to AMG 510

Summary for 8TLR

Entry DOI	10.2210/pdb8tlr/pdb
Descriptor	GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, AMG 510 (bound form), ... (5 entities in total)
Functional Keywords	hras, h-ras, sotorasib, ras, oncoprotein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	19951.40
Authors	Morstein, J.,Guiley, K.Z.,Shokat, K.M. (deposition date: 2023-07-27, release date: 2024-07-31, Last modification date: 2024-09-25)
Primary citation	Morstein, J.,Bowcut, V.,Fernando, M.,Yang, Y.,Zhu, L.,Jenkins, M.L.,Evans, J.T.,Guiley, K.Z.,Peacock, D.M.,Krahnke, S.,Lin, Z.,Taran, K.A.,Huang, B.J.,Stephen, A.G.,Burke, J.E.,Lightstone, F.C.,Shokat, K.M. Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket. Cell, 2024 Cited by PubMed: 39255801 DOI: 10.1016/j.cell.2024.08.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.70003947485 Å)

Structure validation