8TLR
Crystal Structure of human HRAS G12C covalently bound to AMG 510
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | GTPase HRas | polymer | 166 | 18921.3 | 1 | UniProt (P01112) Pfam (PF00071) In PDB | Homo sapiens (human) | |
2 | A | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
3 | A | AMG 510 (bound form) | non-polymer | 562.6 | 1 | Chemie (MOV) | |||
4 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
5 | water | water | 18.0 | 107 | Chemie (HOH) |
Sequence modifications
A: 1 - 166 (UniProt: P01112)
PDB | External Database | Details |
---|---|---|
Cys 12 | Gly 12 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 18921.3 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 1030.1 | |
All* | Total formula weight | 19951.4 |