6G60
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6GME
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4PF7
| Crystal structure of insulin degrading enzyme complexed with inhibitor | 分子名称: | (2S)-2-amino-N-{(1S)-1-cyclohexyl-2-[(4-methylphenyl)amino]-2-oxoethyl}-4-(methylselanyl)butanamide, Insulin-degrading enzyme, ZINC ION | 著者 | Wang, Y, Guo, S. | 登録日 | 2014-04-28 | 公開日 | 2015-06-17 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo. J.Biol.Chem., 290, 2015
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8RBX
| Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome complex | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... | 著者 | Fianu, I, Ochmann, M, Walshe, J.L, Cramer, P. | 登録日 | 2023-12-05 | 公開日 | 2024-02-07 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural basis of Integrator-dependent RNA polymerase II termination. Nature, 629, 2024
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8RC4
| Structure of Integrator-PP2A complex | 分子名称: | DSS1, Integrator complex subunit 1, Integrator complex subunit 10, ... | 著者 | Fianu, I, Ochmann, M, Walshe, J.L, Cramer, P. | 登録日 | 2023-12-06 | 公開日 | 2024-02-07 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis of Integrator-dependent RNA polymerase II termination. Nature, 629, 2024
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8RBZ
| Structure of Integrator-PP2A-SOSS-CTD post-termination complex | 分子名称: | DNA-directed RNA polymerase subunit, DSS1, Integrator complex subunit 1, ... | 著者 | Fianu, I, Ochmann, M, Walshe, J.L, Cramer, P. | 登録日 | 2023-12-05 | 公開日 | 2024-02-07 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural basis of Integrator-dependent RNA polymerase II termination. Nature, 629, 2024
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6GIK
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6GMH
| Structure of activated transcription complex Pol II-DSIF-PAF-SPT6 | 分子名称: | CDC73, CTR9,RNA polymerase-associated protein CTR9 homolog,RNA polymerase-associated protein CTR9 homolog, DNA-directed RNA polymerase II subunit RPB9, ... | 著者 | Vos, S.M, Farnung, L, Boehing, M, Linden, A, Wigge, C, Urlaub, H, Cramer, P. | 登録日 | 2018-05-26 | 公開日 | 2018-08-22 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure of activated transcription complex Pol II-DSIF-PAF-SPT6. Nature, 560, 2018
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2FJB
| Adenosine-5'-phosphosulfate reductase im complex with products | 分子名称: | (S)-10-((2S,3S,4R)-5-((S)-((S)-(((2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHOXY)(HYDROXY)PHOSPHORYLOXY)(HYDROXY)PHOSPHORYLOXY)-2,3,4-TRIHYDROXYPENTYL)-7,8-DIMETHYL-2,4-DIOXO-2,3,4,4A-TETRAHYDROBENZO[G]PTERIDINE-5(10H)-SULFONIC ACID, ADENOSINE MONOPHOSPHATE, IRON/SULFUR CLUSTER, ... | 著者 | Schiffer, A, Fritz, G, Kroneck, P.M, Ermler, U. | 登録日 | 2006-01-02 | 公開日 | 2006-03-28 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Reaction mechanism of the iron-sulfur flavoenzyme adenosine-5'-phosphosulfate reductase based on the structural characterization of different enzymatic states Biochemistry, 45, 2006
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2FJE
| adenosine-5-phosphosulfate reductase oxidized state | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, IRON/SULFUR CLUSTER, adenylylsulfate reductase, ... | 著者 | Schiffer, A, Fritz, G, Kroneck, P.M, Ermler, U. | 登録日 | 2006-01-02 | 公開日 | 2006-03-28 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Reaction mechanism of the iron-sulfur flavoenzyme adenosine-5'-phosphosulfate reductase based on the structural characterization of different enzymatic states Biochemistry, 45, 2006
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2FJD
| adenosine-5-phosphosulfate reductase in complex with sulfite (covalent adduct) | 分子名称: | (S)-10-((2S,3S,4R)-5-((S)-((S)-(((2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHOXY)(HYDROXY)PHOSPHORYLOXY)(HYDROXY)PHOSPHORYLOXY)-2,3,4-TRIHYDROXYPENTYL)-7,8-DIMETHYL-2,4-DIOXO-2,3,4,4A-TETRAHYDROBENZO[G]PTERIDINE-5(10H)-SULFONIC ACID, IRON/SULFUR CLUSTER, adenylylsulfate reductase, ... | 著者 | Schiffer, A, Fritz, G, Kroneck, P.M, Ermler, U. | 登録日 | 2006-01-02 | 公開日 | 2006-03-28 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Reaction mechanism of the iron-sulfur flavoenzyme adenosine-5'-phosphosulfate reductase based on the structural characterization of different enzymatic states Biochemistry, 45, 2006
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2FJA
| adenosine 5'-phosphosulfate reductase in complex with substrate | 分子名称: | ADENOSINE-5'-PHOSPHOSULFATE, FLAVIN-ADENINE DINUCLEOTIDE, IRON/SULFUR CLUSTER, ... | 著者 | Schiffer, A, Fritz, G, Kroneck, P.M, Ermler, U. | 登録日 | 2006-01-02 | 公開日 | 2006-03-28 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Reaction mechanism of the iron-sulfur flavoenzyme adenosine-5'-phosphosulfate reductase based on the structural characterization of different enzymatic states Biochemistry, 45, 2006
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2EBU
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2FO0
| Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase | 分子名称: | 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, GLYCEROL, MYRISTIC ACID, ... | 著者 | Nagar, B, Hantschel, O, Seeliger, M, Davies, J.M, Weis, W.I, Superti-Furga, G, Kuriyan, J. | 登録日 | 2006-01-12 | 公開日 | 2006-03-21 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase. Mol.Cell, 21, 2006
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5DOL
| Crystal structure of YabA amino-terminal domain from Bacillus subtilis | 分子名称: | Initiation-control protein YabA | 著者 | Cherrier, M.V, Bazin, A, Jameson, K.H, Wilkinson, A.J, Noirot-Gros, M.F, Terradot, L. | 登録日 | 2015-09-11 | 公開日 | 2016-01-20 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Tetramerization and interdomain flexibility of the replication initiation controller YabA enables simultaneous binding to multiple partners. Nucleic Acids Res., 44, 2016
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5E05
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5E04
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5E0T
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3FKI
| 12-Subunit RNA Polymerase II Refined with Zn-SAD data | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | 著者 | Meyer, P.A, Ye, P, Suh, M.H, Zhang, M, Fu, J. | 登録日 | 2008-12-16 | 公開日 | 2009-03-10 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.88 Å) | 主引用文献 | Structure of the 12-Subunit RNA Polymerase II Refined with the Aid of Anomalous Diffraction Data J.Biol.Chem., 284, 2009
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3CW4
| Large c-terminal domain of influenza a virus RNA-dependent polymerase PB2 | 分子名称: | Polymerase basic protein 2 | 著者 | Kuzuhara, T, Kise, D, Yoshida, H, Horita, T, Murasaki, Y, Utsunomiya, H, Fujiki, H, Tsuge, H. | 登録日 | 2008-04-21 | 公開日 | 2009-01-13 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis of the influenza A virus RNA polymerase PB2 RNA-binding domain containing the pathogenicity-determinant lysine 627 residue J.Biol.Chem., 284, 2009
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5FHM
| Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with (S)-2-Amino-3-(5-(2-(3-(aminomethyl)benzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid at resolution 1.55 A resolution | 分子名称: | (2~{S})-3-[5-[2-[[3-(aminomethyl)phenyl]methyl]-1,2,3,4-tetrazol-5-yl]-3-oxidanyl-1,2-oxazol-4-yl]-2-azanyl-propanoic acid, 1,2-ETHANEDIOL, ACETATE ION, ... | 著者 | Kastrup, J.S, Frydenvang, K, Al-musaed, A. | 登録日 | 2015-12-22 | 公開日 | 2016-03-02 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Tweaking Subtype Selectivity and Agonist Efficacy at (S)-2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) Receptors in a Small Series of BnTetAMPA Analogues. J.Med.Chem., 59, 2016
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5FYW
| Transcription initiation complex structures elucidate DNA opening (OC) | 分子名称: | DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2, ... | 著者 | Plaschka, C, Hantsche, M, Dienemann, C, Burzinski, C, Plitzko, J, Cramer, P. | 登録日 | 2016-03-10 | 公開日 | 2016-05-18 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (4.35 Å) | 主引用文献 | Transcription Initiation Complex Structures Elucidate DNA Opening Nature, 533, 2016
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5FZ5
| Transcription initiation complex structures elucidate DNA opening (CC) | 分子名称: | DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2, ... | 著者 | Plaschka, C, Hantsche, M, Dienemann, C, Burzinski, C, Plitzko, J, Cramer, P. | 登録日 | 2016-03-10 | 公開日 | 2016-05-18 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (8.8 Å) | 主引用文献 | Transcription Initiation Complex Structures Elucidate DNA Opening Nature, 533, 2016
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5FHO
| Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with (S)-2-Amino-3-(5-(2-(3-chlorobenzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid at 2.3 A resolution | 分子名称: | (1S)-1-carboxy-2-(5-{2-[(3-chlorophenyl)methyl]-2H-tetrazol-5-yl}-3-oxo-2,3-dihydro-1,2-oxazol-4-yl)ethan-1-aminium, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Frydenvang, K, Kastrup, J.S. | 登録日 | 2015-12-22 | 公開日 | 2016-03-02 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Tweaking Subtype Selectivity and Agonist Efficacy at (S)-2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) Receptors in a Small Series of BnTetAMPA Analogues. J.Med.Chem., 59, 2016
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5FHN
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