8H3K
 
 | | Crystal Structure of SARS-CoV-2 Main Protease (Mpro) Double Mutant (L50F and E166V) in Complex with Inhibitor Enstrelvir | | 分子名称: | 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM, 3C-like proteinase nsp5, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione, ... | | 著者 | Wang, H, Lin, M, Duan, Y, Zhang, X, Zhou, H, Bian, Q, Liu, X, Rao, Z, Yang, H. | | 登録日 | 2022-10-08 | | 公開日 | 2023-10-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir.
Nature, 622, 2023
|
|
8H38
 | | Cryo-EM Structure of the KBTBD2-CRL3~N8-CSN(mutate) complex | | 分子名称: | COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ... | | 著者 | Hu, Y, Mao, Q, Chen, Z, Sun, L. | | 登録日 | 2022-10-08 | | 公開日 | 2023-10-11 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4.25 Å) | | 主引用文献 | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2.
Nat.Struct.Mol.Biol., 31, 2024
|
|
8H53
 | |
8H58
 | |
8H75
 | | FGFR2 in complex with YJ001 | | 分子名称: | CHLORIDE ION, Fibroblast growth factor receptor 2, Tinengotinib | | 著者 | Yan, X.E, Yun, C.H. | | 登録日 | 2022-10-19 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (3.75 Å) | | 主引用文献 | FGFR2 in complex with YJ001
To Be Published
|
|
8H8P
 | | Crystal structure of thiomorpholine-carboxylate dehydrogenase from Candida parapsilosis. | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, MAGNESIUM ION, ... | | 著者 | Uma Mahesh, M.V.N, Abhishek, S, Faidh, M.A, Rajakumara, E, Chadha, A. | | 登録日 | 2022-10-24 | | 公開日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure and mechanism of a Ornithine cyclodeaminase/Mu-crystallin homolog purified from Candida parapsilosis ATCC 7330.
To Be Published
|
|
8H2R
 | |
6A38
 | | MVM NS2 NES in complex with CRM1-Ran-RanBP1 | | 分子名称: | 1,2-ETHANEDIOL, Exportin-1, GLYCEROL, ... | | 著者 | Sun, Q, Li, Y. | | 登録日 | 2018-06-15 | | 公開日 | 2019-06-19 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | | 主引用文献 | Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor.
Int J Nanomedicine, 16, 2021
|
|
8H37
 | | Cryo-EM Structure of the KBTBD2-CUL3-Rbx1-p85a tetrameric complex | | 分子名称: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... | | 著者 | Hu, Y, Mao, Q, Chen, Z, Sun, L. | | 登録日 | 2022-10-08 | | 公開日 | 2023-10-11 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (7.52 Å) | | 主引用文献 | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2.
Nat.Struct.Mol.Biol., 31, 2024
|
|
8H6H
 | |
6JZ0
 | | Crystal structure of EGFR kinase domain in complex with compound 78 | | 分子名称: | E-4-(dimethylamino)-N-[3-[4-[[(1S)-2-oxidanyl-1-phenyl-ethyl]amino]-6-phenyl-furo[2,3-d]pyrimidin-5-yl]phenyl]but-2-enamide, Epidermal growth factor receptor | | 著者 | Peng, Y.H, Wu, J.S, Wu, S.Y. | | 登録日 | 2019-04-30 | | 公開日 | 2019-12-04 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | | 主引用文献 | Discovery of a Furanopyrimidine-Based Epidermal Growth Factor Receptor Inhibitor (DBPR112) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer.
J.Med.Chem., 62, 2019
|
|
8HAR
 | | SAH-bound C-Methyltransferase Fur6 from Streptomyces sp. KO-3988 | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Fur6, S-ADENOSYL-L-HOMOCYSTEINE | | 著者 | Noguchi, T, Nagata, R, Tomita, T, Kuzuyama, T. | | 登録日 | 2022-10-26 | | 公開日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | | 主引用文献 | Reductive biosynthesis of meroterpenoids via transient diazotization
To Be Published
|
|
8HEY
 | | One CVSC-binding penton vertex in HCMV B-capsid | | 分子名称: | Capsid vertex component 1, Capsid vertex component 2, Major capsid protein, ... | | 著者 | Li, Z, Yu, X. | | 登録日 | 2022-11-09 | | 公開日 | 2023-11-01 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Cryo-electron microscopy structures of capsids and in situ portals of DNA-devoid capsids of human cytomegalovirus.
Nat Commun, 14, 2023
|
|
8HD0
 | | Cell divisome sPG hydrolysis machinery FtsEX-EnvC | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cell division ATP-binding protein FtsE, Cell division protein FtsX, ... | | 著者 | Zhang, Z, Chen, Y. | | 登録日 | 2022-11-03 | | 公開日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | | 主引用文献 | Structural insight into the septal peptidoglycan hydrolysis machinery of bacterial cell division
To Be Published
|
|
8HFQ
 | | Cryo-EM structure of CpcL-PBS from cyanobacterium Synechocystis sp. PCC 6803 | | 分子名称: | C-phycocyanin alpha subunit, C-phycocyanin beta subunit, Ferredoxin--NADP reductase, ... | | 著者 | Zheng, L, Zhang, Z, Wang, H, Zheng, Z, Gao, N, Zhao, J. | | 登録日 | 2022-11-11 | | 公開日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | | 主引用文献 | Cryo-EM and femtosecond spectroscopic studies provide mechanistic insight into the energy transfer in CpcL-phycobilisomes.
Nat Commun, 14, 2023
|
|
8GW7
 | | AtSLAC1 6D mutant in open state | | 分子名称: | CHLORIDE ION, CHOLESTEROL HEMISUCCINATE, Guard cell S-type anion channel SLAC1,Green fluorescent protein (Fragment) | | 著者 | Lee, Y, Lee, S. | | 登録日 | 2022-09-16 | | 公開日 | 2023-11-15 | | 最終更新日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Cryo-EM structures of the plant anion channel SLAC1 from Arabidopsis thaliana suggest a combined activation model.
Nat Commun, 14, 2023
|
|
8HCY
 | | Legionella glycosyltransferase | | 分子名称: | Dot/Icm secretion system substrate | | 著者 | Chen, T.T, Ouyang, S.Y. | | 登録日 | 2022-11-03 | | 公開日 | 2023-11-08 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | | 主引用文献 | Structural Basis for the Action Mechanism of Legionella Glycosyltransferase.
Small Struct, 2023
|
|
8H4F
 | | Blasnase-T13A/P55F with D-asn | | 分子名称: | D-ASPARAGINE, FORMIC ACID, L-asparaginase, ... | | 著者 | Lu, F, Wang, W, Chi, H, Ran, T. | | 登録日 | 2022-10-10 | | 公開日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure-based rational design of Bacillus licheniformis L-asparaginase with low/no D-asparaginase activity for a safer enzyme
To Be Published
|
|
8HE7
 | | ADP-ribosyltransferase 1 (PARP1) catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor | | 分子名称: | 1-[[4-fluoranyl-3-(3-oxidanylidene-4-pentan-3-yl-piperazin-1-yl)carbonyl-phenyl]methyl]quinazoline-2,4-dione, Poly [ADP-ribose] polymerase 1, processed C-terminus, ... | | 著者 | Wang, X.Y, Zhou, J, Xu, B.L. | | 登録日 | 2022-11-07 | | 公開日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Discovery of Quinazoline-2,4(1 H ,3 H )-dione Derivatives Containing a Piperizinone Moiety as Potent PARP-1/2 Inhibitors─Design, Synthesis, In Vivo Antitumor Activity, and X-ray Crystal Structure Analysis.
J.Med.Chem., 66, 2023
|
|
8HCJ
 | | Structure of GH43 family enzyme, Xylan 1, 4 Beta- xylosidase from pseudopedobacter saltans | | 分子名称: | CALCIUM ION, Xylan 1,4-beta-xylosidase | | 著者 | Vishwakarma, P, Sachdeva, E, Goyal, A, Ethayathulla, A.S, Das, U, Kaur, P. | | 登録日 | 2022-11-01 | | 公開日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.566 Å) | | 主引用文献 | Structure of GH43 family enzyme, Xylan 1, 4 Beta- xylosidase from pseudopedobacter saltans
To Be Published
|
|
2VJ8
 | | Complex of human leukotriene A4 hydrolase with a hydroxamic acid inhibitor | | 分子名称: | 6-[{(2S)-2-AMINO-3-[4-(BENZYLOXY)PHENYL]PROPYL}(HYDROXY)AMINO]-6-OXOHEXANOIC ACID), ACETATE ION, IMIDAZOLE, ... | | 著者 | Thunnissen, M.M.G.M, Andersson, B, Wong, C.-H, Samuelsson, B, Haeggstrom, J.Z. | | 登録日 | 2007-12-07 | | 公開日 | 2008-01-15 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal Structures of Leukotriene A4 Hydrolase in Complex with Captopril and Two Competitive Tight-Binding Inhibitors
Faseb J., 16, 2002
|
|
8HKD
 | |
8HHJ
 | |
8HDZ
 | | Monkeypox virus DNA replication holoenzyme F8, A22 and E4 complex in an apo form | | 分子名称: | A22 DNA replication processivity factor, E4 uracil-DNA glycosylase, F8 DNA polymerase | | 著者 | Xu, Y, Wu, Y, Zhang, Y, Fan, R, Yang, Y, Li, D, Yang, B, Zhang, Z, Dong, C. | | 登録日 | 2022-11-07 | | 公開日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | | 主引用文献 | Cryo-EM structures of human monkeypox viral replication complexes with and without DNA duplex.
Cell Res., 33, 2023
|
|
8GW6
 | | AtSLAC1 6D mutant in closed state | | 分子名称: | CHLORIDE ION, CHOLESTEROL HEMISUCCINATE, Guard cell S-type anion channel SLAC1,Green fluorescent protein (Fragment) | | 著者 | Lee, Y, Lee, S. | | 登録日 | 2022-09-16 | | 公開日 | 2023-11-15 | | 最終更新日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Cryo-EM structures of the plant anion channel SLAC1 from Arabidopsis thaliana suggest a combined activation model.
Nat Commun, 14, 2023
|
|
