8H53
Human asparaginyl-tRNA synthetase in complex with asparagine-AMP
Summary for 8H53
Entry DOI | 10.2210/pdb8h53/pdb |
Descriptor | Asparagine--tRNA ligase, cytoplasmic, 4-AMINO-1,4-DIOXOBUTAN-2-AMINIUM ADENOSINE-5'-MONOPHOSPHATE, IMIDODIPHOSPHORIC ACID, ... (6 entities in total) |
Functional Keywords | asparagine, complex, synthetase, trna, rna binding protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 221176.26 |
Authors | Park, J.S.,Han, B.W. (deposition date: 2022-10-12, release date: 2023-10-25, Last modification date: 2024-05-08) |
Primary citation | Xie, S.C.,Wang, Y.,Morton, C.J.,Metcalfe, R.D.,Dogovski, C.,Pasaje, C.F.A.,Dunn, E.,Luth, M.R.,Kumpornsin, K.,Istvan, E.S.,Park, J.S.,Fairhurst, K.J.,Ketprasit, N.,Yeo, T.,Yildirim, O.,Bhebhe, M.N.,Klug, D.M.,Rutledge, P.J.,Godoy, L.C.,Dey, S.,De Souza, M.L.,Siqueira-Neto, J.L.,Du, Y.,Puhalovich, T.,Amini, M.,Shami, G.,Loesbanluechai, D.,Nie, S.,Williamson, N.,Jana, G.P.,Maity, B.C.,Thomson, P.,Foley, T.,Tan, D.S.,Niles, J.C.,Han, B.W.,Goldberg, D.E.,Burrows, J.,Fidock, D.A.,Lee, M.C.S.,Winzeler, E.A.,Griffin, M.D.W.,Todd, M.H.,Tilley, L. Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nat Commun, 15:937-937, 2024 Cited by PubMed: 38297033DOI: 10.1038/s41467-024-45224-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.16 Å) |
Structure validation
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